Sr. Program Strategy and Operations Director

This position is listed on behalf of a partner company, who manages all applications and next steps. Our partner is looking for a Sr. Program Strategy and Operations Director based in the United States.

This role sits at the intersection of strategy, science, and operations within a fast-moving, clinical-stage biotech environment. You will serve as a strategic and operational partner to an Asset Entrepreneur, helping shape decisions that directly influence the development of a high-potential medicine. Acting as the COO of a single-asset biotech program, you will drive execution across clinical, translational, regulatory, CMC, and commercial functions. You will transform complex scientific and operational information into clear, data-driven recommendations for executives, the Board, and investors. The role combines strategic thinking with hands-on execution, requiring you to identify obstacles, mobilize teams, and keep critical programs moving. You will also help build scalable operating practices, institutional knowledge, and a playbook for future development programs. This is an opportunity for an ambitious biotech leader to have visible impact on both an individual asset and the broader evolution of a growing organization.

Accountabilities:

• Act as a strategic thought partner to the Asset Entrepreneur, anticipating key program inflection points and evaluating scenarios to determine when to accelerate, pivot, or pause development activities.
• Own end-to-end program execution, operating as the operational lead for a single-asset biotech program and ensuring priorities, decisions, resources, and dependencies remain aligned.
• Coordinate closely across clinical, translational, regulatory, CMC, commercial, and other functional teams to maintain momentum and resolve obstacles.
• Identify and address execution gaps proactively, including coordinating internal stakeholders, mobilizing CROs and external partners, and creating practical solutions when challenges arise.
• Translate complex scientific, clinical, regulatory, and operational information into concise analyses, recommendations, presentations, and executive-level communications.
• Prepare clear, data-driven materials for C-suite leadership, Board discussions, investor engagements, and business development activities.
• Maintain disciplined program documentation, including key decisions, assumptions, benchmarks, dashboards, trackers, and action plans.
• Manage external vendors, advisors, CROs, and strategic partners while building relationships with leading experts within the relevant disease area.
• Support the development of scientific narratives around novel molecules and emerging biology, helping communicate their potential to patients, clinicians, investors, and other stakeholders.
• Contribute to company-wide operating knowledge by documenting benchmarks, lessons learned, best practices, and scalable approaches for future programs.
• Support the evolution of organizational culture, operating models, and processes as the organization expands across multiple diseases, mechanisms, and future commercial opportunities.
• Travel approximately monthly to meet with internal teams and key external stakeholders.

Requirements:

• Significant experience in biotech or pharmaceutical program management, portfolio or asset strategy, management consulting, business operations, or a comparable strategic role.
• Demonstrated ability to connect strategic thinking with hands-on execution in complex, cross-functional environments.
• Strong understanding of drug development and the ability to work effectively across clinical, translational, regulatory, CMC, and commercial disciplines.
• Proven ability to synthesize large volumes of complex information into clear, actionable insights and compelling executive-level recommendations.
• Exceptional written and verbal communication skills, including the ability to produce concise, data-driven presentations, slides, and executive memos.
• Strong analytical and problem-solving capabilities, with the judgment to evaluate risks, trade-offs, scenarios, and program inflection points.
• Demonstrated fluency with AI tools and the ability to incorporate AI into workflows as a practical multiplier of human judgment, creativity, and productivity.
• Hands-on, entrepreneurial mindset with a willingness to personally address gaps and execute beyond traditional role boundaries when necessary.
• Ability to thrive in ambiguity, move comfortably between long-term strategy and tactical execution, and maintain momentum in a rapidly evolving environment.
• Strong emotional intelligence, humility, integrity, and collaborative leadership style.
• High intellectual curiosity, analytical rigor, optimism, and the ability to motivate and align diverse stakeholders.
• Willingness to travel approximately once per month for team and external stakeholder engagements.
• A growth-oriented mindset and demonstrated trajectory are valued alongside traditional credentials.

Benefits:

• Annual salary range of $275,000–$300,000 .
• Fully remote position within the United States.
• Medical, dental, and vision coverage at 90% , beginning on the first day.
• 401(k) plan with company match .
• Flexible paid time off.
• Company-wide weeklong recharge break.
• Adoption assistance.
• Opportunity to work at the intersection of AI, drug discovery, science, strategy, and operations.
• High-impact position with direct visibility into strategic decisions, asset development, investor engagement, and company building.
• Opportunity to work closely with senior scientific, clinical, commercial, and executive stakeholders.
• Significant autonomy and ownership within a fast-growing biotech environment.
• Opportunity to help establish operating practices and institutional knowledge that will shape future development programs.

How Jobgether works:

We use an AI-powered matching process to ensure your application is reviewed quickly, objectively, and fairly against the role's core requirements. Our system identifies the top-fitting candidates, and this shortlist is then shared directly with the hiring company. The final decision and next steps (interviews, assessments) are managed by their internal team.

We appreciate your interest and wish you the best!

Data Privacy Notice: By submitting your application, you acknowledge that Jobgether will process your personal data to evaluate your candidacy and share relevant information with the hiring employer. This processing is based on legitimate interest and pre-contractual measures under applicable data protection laws (including GDPR). You may exercise your rights (access, rectification, erasure, objection) at any time.

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We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses and identifying potential inconsistencies or verification signals in application materials based on available information. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.