Group Leader - Senior Director, Quantitative Pharmacology and Pharmacometrics - Cardiometabolic

Job Description This role provides strategic leadership and scientific oversight to part of the cardiometabolic (CMD) therapeutic area (TA) portfolio in the department of Quantitative Pharmacology and Pharmacometrics (QP2). The Team Leader (Senior Director) is responsible for application of cutting‑edge quantitative pharmacology and pharmacometrics strategies to propel the internal portfolio forward leveraging the full strength of the QP2 department. The CMD TA Team Leader will be tasked with overseeing a team of QP2 scientists, providing guidance in personnel management, scientific strategy, and operational execution, in addition to serving as QP2 lead on assigned projects. Reporting directly to the QP2 CMD Head and serving as their delegate when needed, the individual will collaborate closely with the QP2 CMD leadership team and broader organization to ensure consistent, high-value quantitative pharmacology contributions throughout the CMD portfolio from discovery through life cycle management. This role is also part of the extended QP2 leadership team and expected to bring leadership and active contributions to one or more business or talent facing workstreams. Senior Directors are recognized as scientific thought leaders that develop and implement translational PK/PD strategies, characterize clinical pharmacokinetics and pharmacodynamics, and shape regulatory strategy, dose selection and go/no‑go decisions. Responsibilities Leading a team of up to 4 QP2 scientists including people management, scientific and operational oversight, under the direction of the Executive Director of QP2‑CMD. Leveraging end‑to‑end drug discovery/development and disease area expertise to independently provide day‑to‑day scientific oversight to individual contributors. Setting priorities for direct reports and driving performance management, hiring and retention, staff development and training, and input into calibration and talent management processes. Serving as an expert representative for QP2 on discovery and drug development teams and engaging in cross‑functional and governance discussions, including business development and licensing evaluations. Maintaining a comprehensive understanding of global regulatory expectations for small molecules and biologics, contributing to cross‑functional regulatory strategy, authoring regulatory documents (INDs, CSRs, CTDs). Developing and applying mechanistic, disease progression and comparator modeling platforms to help drive portfolio decisions. In partnership with Executive Director of CMD, identify resource needs and contribute to resource allocation internally. Serve as QP2 lead on assigned projects. Requirements Ph.D./PharmD or equivalent degree with at least 10 years of experience where “experience” means having a record of increasing responsibility and independence in a similar role in pharmaceutical drug development or regulatory. Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical/biomedical engineering, mathematics, statistics/biostatistics, computational biology/chemistry, or a related field. Extensive experience in developing quantitative strategies for impacting pipeline decisions, and drug development expertise. Demonstrated ability to lead an interdisciplinary team or taskforce, and/or to oversee the work of others. Record of ability to operate in an inclusive and high‑performance work environment applying enterprise ways of working principles including fostering collaboration and driving results, while managing ambiguity. Relevant regulatory and quantitative pharmacology experience. Proficiency in written and verbal communication, interdisciplinary collaboration, and problem scoping and planning. Preferred CMD Therapeutic area or disease knowledge. Expert skills in performing population PK/PKPD analyses using standard pharmacometrics software (e.g. NONMEM, R, Monolix, Phoenix, etc.). Scientific understanding of biopharmaceutical and ADME properties across modalities. Record of applying models to inform decisions. Ability to influence regulatory strategies including prior experience independently authoring and defending regulatory filings for marketing authorization (NDA/MAA). Recognized leader in the field of quantitative pharmacology with a track record of sustained external visibility through publications, presentations and/or involvement in professional organizations. Remote / Hybrid This opportunity will be hybrid or remote, but the remote position is only applicable for those that are not within commutable distance to primary sites noted in posting. If commutable, the position will be hybrid. Please note that standard commute is (less than) 50 miles. Salary and Benefits The salary range for this role is $210,400.00 - $331,100.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at Equal Employment Opportunity As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC GINA Supplement. Learn more about your rights, including under California, Colorado and other US State Acts #J-18808-Ljbffr Merck