Sr. Principal Scientist - Cell Line Development
$140k - $187kEPM Scientific
Sr. Principal Scientist - Cell Line Development (PR/595784) Massachusetts, USA Salary: USD140000 - USD187000 per year Sr. Principal Scientist, Cell Line Development Summary Our firm is currently partnered with a growing biopharmaceutical development organization seeking an Associate Director of Cell Line Development to lead its mammalian cell line and microbial strain development capabilities. This individual will lead a team of scientists and associates responsible for developing high-performing expression systems for monoclonal antibodies, recombinant proteins, and other therapeutic products. As a key member of the Biopharmaceutical Development leadership team, the Associate Director will help shape the strategic growth of the cell line development function while providing technical leadership across client programs. Key Responsibilities Lead the development and optimization of mammalian cell lines and microbial strains for therapeutic protein production. Oversee activities spanning vector construction, screening, transfection, media optimization, stable cell line development, and cell banking. Manage recombinant protein characterization activities, including ELISA, PCR, SDS-PAGE, and Western blot. Provide scientific and operational leadership to a team of scientists and research associates. Support the preparation of cell line and strain development documentation for IND, BLA, and broader CMC submissions. Drive innovation projects, evaluate emerging technologies, and oversee the implementation of new platforms and capabilities. Represent the cell line development function in client meetings and provide technical support to business development and commercial teams. Contribute to departmental strategy, capability expansion, resource planning, and budget management. Author and review SOPs, protocols, technical reports, and development documentation. Ensure programs meet applicable regulatory expectations, technical standards, and project timelines. Mentor and develop team members while fostering a collaborative, results-oriented environment. Qualifications S., M.S., or Ph.D. in Molecular Biology, Cell Biology, Biochemistry, Biotechnology, or a related scientific discipline. D. with at least 5-7 years, M.S. with 8-11 years, or B.S. with at least 12-16 years of relevant industry experience. Demonstrated expertise in mammalian cell line development and expression technologies supporting monoclonal antibody and recombinant protein therapeutics. Hands-on experience with mammalian expression systems such as CHO, HEK, and NS0. Experience with the CHO-GS platform is highly desirable. Experience developing cell lines for bispecific antibodies or other complex biologics is strongly preferred. Familiarity with microbial strain development and optimization. Strong understanding of PAT technologies, GMP expectations, ICH guidelines, and CMC development. Experience supporting IND/BLA documentation and regulatory submissions. Proficiency in statistical design of experiments and data analysis using JMP, Minitab, Design-Expert, or comparable software. Demonstrated ability to lead technical programs, solve complex development challenges, and make strategic recommendations to senior leadership. Strong team leadership, project management, organizational, and cross-functional communication skills. #J-18808-Ljbffr EPM Scientific
$154.4k - $242.55k
...provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use.... ....Job DescriptionJoin Takeda as a The Senior/Principal Scientist, Analytical Cell Line Engineering and Bioessay Development plays a key role in managing and performing scientific...PrincipalSeniorMinimum wageTemporary workLocal areaShift work- ...developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics. We are seeking a Principal Scientist to join our Biologics Cell Line Development team in Boston, MA and help push the boundaries of...Principal
Asimov
Boston, MA3 days ago - A biotechnology startup in Boston is seeking a Senior or Principal Scientist to lead CHO-based cell line development. This role involves managing a team and driving innovation in biotherapeutics. The ideal candidate has over 5 years of experience in CHO cell line development...Senior
$154.4k - $242.55k
...information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I... ...knowledge.Job DescriptionJoin Takeda as a Senior/Principal Scientist, Cell Based-Potency Assay Development. As an expert professional within the organization,...PrincipalSeniorMinimum wageContract workTemporary workLocal area$130k - $165k
Scientist / Senior Scientist - Cell Line Development Company Overview GC Therapeutics is the first genome-wide cell landscape exploration company using an integrated synthetic biology and AI-driven platform for cell programming. Its patent-pending and proprietary pluripotent...SeniorContract workLocal area- ...Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell Depletion Group within the Immune Reset Therapeutics... ...collaborate and deliver results across multi-disciplinary line functions both internally and with external leading experts...PrincipalSeniorWork experience placement
- ...Job Responsibilities • Work with team members to drive forward new gene therapy programs • Perform cell culture and molecular biology experiments and establish new functional assays to measure gene therapy outcomes both in vitro and in vivo. • Establish...PrincipalSeniorFull timeH1bVisa sponsorshipWork visa
Saviance
Boston, MAa month ago - A biotechnology startup in Boston is looking for a Principal Scientist to lead CHO-based cell line development. In this role, you will conduct and supervise innovative cell line development for biologics, manage a team of scientists, and represent the company in external...
- ...Job Title: Associate Scientist/ Sr. Associate Scientist Antibody... ...biology and the development of fibrosis... ...Associate scientist, or Principal Research Associate to... ...Maintain mammalian cell culture (HEK293 and CHO... ...includes media prep, cell line maintenance, cryopreservation...PrincipalSeniorWork at officeLocal area
Mediar Therapeutics
Boston, MA1 day ago - GC Therapeutics seeks a Scientist or Senior Scientist to advance iPSC-based cell line development from bench to production scale. You will engineer iPSC-derived products for regenerative therapies and contribute to early-phase clinical candidates within a cross-functional...Senior
$163k - $214.5k
...recruiting a team of top-tier scientists to help build it. This is a... ...originated and fostered the development of more than 100 scientific... ...motivated and highly collaborative Principal Scientist to design, stand... ...in primary and primary-like cell lines). This role is among the...Principal$120k - $160k
...QC Senior/Principal Scientist, Analytical Method Validation Lexington... .... We provide process development, produce GMP viral vectors, and provide cell transduction for gene... ...with Critical Material Sr. Scientist to design and... ...bioassays using mammalian cell-lines (such as HELA, HEK-293,...PrincipalSeniorImmediate startVisa sponsorshipGenezen
Lexington, MA4 days ago$190.8k - $300.3k
...authorities. We work across functions and geographies to advance development programs and maintain licensure for the General Medicine... ...challenges with rigor and professionalism.The Senior Principal Scientist, Regulatory Affairs Liaison is responsible for the development...PrincipalSeniorFull timeFor contractorsLocal areaWorldwideFlexible hours$152.6k - $283.4k
...advancing biomarker science that helps transform promising discoveries into life-changing medicines. As a Sr Principal Scientist / Associate Director, Biomarker Assay Development Laboratory, you will lead a high-performing team at the forefront of translational research,...PrincipalSeniorFull timeContract workLocal areaFlexible hours- ...Therapeutic Area is seeking an accomplished and experienced Scientist to lead the Immune Cell Depletion Group within the Immune Reset Therapeutics... ...collaborate and deliver results across multi-disciplinary line functions both internally and with external leading experts...PrincipalSeniorFull timeWork experience placementLocal area
- CRISPR Therapeutics is seeking a Senior Scientist in Analytical Development to lead development, qualification and technology transfer of cell-based potency assays, collaborating across programs and with external partners. You will oversee assay lifecycle, mentor scientists...Senior
- Aurion Biotech in Cambridge, MA is seeking a Senior Scientist, Analytical Development to lead analytical method development for cell therapy products. You will work with cross-functional teams to develop, qualify, and transfer assays supporting clinical manufacturing and...Senior
- CRISPR Therapeutics, Inc. in Boston, MA, seeks a Senior Scientist in Analytical Development to drive development, implementation, and qualification of cell-based assays and to lead transfers to collaborators. This role will author sections of regulatory briefing packages...Senior
- A biopharmaceutical company is looking for a Senior Scientist, Process Development to join their Watertown, MA team. This role involves executing cell culture experiments and downstream processing, along with data analysis and project contributions. The ideal candidate...Senior
- Aurion Biotech, Inc. is seeking a Senior Scientist for Analytical Development in Cambridge, MA, to execute assays for cell therapy products. The role encompasses conducting independent experiments, collaborating with various teams, and authoring technical documents for...Senior
$145k - $190k
A biotechnology startup in Boston is seeking a Senior or Principal Scientist to lead CHO-based cell line development for biotherapeutics. This role involves designing and supervising development processes while managing a team of junior scientists. The ideal candidate will...Senior$138.6k - $257.4k
...Novartis Biomedical Research is seeking an accomplished Imaging Scientist to join the Image Analysis team in Cambridge.This role is for... ...image datasetsStrong understanding of tissue-based biomarker development, oncology biology, and translational researchStrong organizational...PrincipalSeniorFull time$108.5k - $201.5k
...Summary#LI-OnsiteInternal job title: Principal Scientist ILocation: Cambridge, United StatesWe... ...soluble biomarker expert to lead the development, validation, and implementation of fit... ...based decisions.Partner with internal line functions and external vendors to deliver...PrincipalFull time$100k - $155k
...highly motivated Senior Associate Scientist to join our Research team and... ...discovery and preclinical development of novel therapeutics for... ...successful candidate will perform cell-based and tissue-based assays... ...including immortalized cell lines and/or iPSC-derived cells....PrincipalSenior$104.2k - $156.2k
General Summary: The Stem Cell Research Scientist works with some independence and is adept at conceptually... ...experimental procedures including the development of human hematopoietic cell models and... ...primary hematopoietic cells and cell lines Collates and interprets data...Summer workFlexible hours$141k - $188k
...Systems Biology group is seeking a highly motivated Principal Scientist to contribute to the development and implementation of biomarker and bioanalytical strategies... ...environment. Proficiency with ligand‑binding and cell‑based assay technologies across multiple platforms....PrincipalFull timeTemporary workLocal areaFlexible hours$208k - $286k
..., and beyond.THE ROLEWe are seeking a Principal Scientist (Embedded ML/Computational) to lead multiple... ..., oversee method and platform development (e.g., systems design, drug design, molecular... ...projects within assigned ventures in line with broader strategic plans of PI and...PrincipalInterim role$125k - $175k
...of protein engineers, biologists, and computational scientists works across this full stack to pursue programs... ...an experienced and highly motivated Scientist for Cell Binding Assay Development to own the cell line and assay development process for discovery and characterization...Senior- ABOUT THE POSITIONThe Senior Scientist, Cell Therapy Process Development position plays a key role in implementing and optimizing processes related to the development of cellular therapies involving primary cells and stem cells. This individual will work independently to...Senior
$145k - $161k
...different tissues, organs and cell types. Prime Medicine is... ...and a clearly defined clinical development and regulatory path, and each... ...driven, discovery-minded Senior Scientist to join our Platform... ...students, with potential dotted-line oversight of additional staff...SeniorFull timeTemporary work
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