Associate Director, Medical Value, Evidence, and Outcomes (MVEO)

Job Description

Job Description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need. 

The Position

Let's do something amazing together! The Associate Director of Medical Value, Evidence, and Outcomes (MVEO) will support the development and execution of medical value evidence strategies for Arrowhead's cardiometabolic portfolio, including plozasiran, an investigational siRNA therapeutic targeting APOC3. This role will contribute to evidence generation, real-world evidence initiatives, payer-focused scientific communication, and cross-functional medical affairs planning to support development and commercialization objectives.

The Associate Director of MVEO will report to the Executive Director, Evidence Generation and Dissemination, and work closely with the Medical Value, Evidence, and Outcomes lead and with partners across Medical Affairs, Market Access, Clinical Development, Biometrics, and Regulatory. The position will help translate clinical, epidemiologic, economic, and real-world data into medically rigorous materials and insights that support evidence-based decision-making and stakeholder engagement.

This role is based in Pasadena with an expectation to be in office 5 days a week.

Depending on experience, this role may be hired at the Sr. Manager level. 

Responsibilities

• Support development and execution of real-world evidence and outcome research studies for Arrowhead's cardiometabolic pipeline, aligned with medical and payer evidence needs.
• Contribute to study concept development, protocol review, vendor engagement, project timelines, data interpretation, and dissemination planning for MVEO initiatives.
• Help develop and review scientific resources, including real-world evidence summaries, epidemiology assessments, budget impact inputs, and payer-facing medical materials.
• Partner with Market Access and field medical colleagues to support medically focused payer discussions and ensure materials are scientifically accurate, balanced, and compliant.
• Collaborate with publications team to support abstracts, manuscripts, congress presentations, and other external communications related to real-world evidence and outcome research.
• Conduct literature reviews, landscape assessments, and horizon scanning to identify evidence gaps and emerging trends in cardiometabolic disease, dyslipidemias, and RNA interference therapeutics.
• Review clinical development plans to assist with endpoint strategies and analytic approaches to align evidence generation with medical, payer, and stakeholder needs.
• Manage day-to-day relationships with external vendors and consultants, including tracking milestones, deliverables, budgets, and internal review processes.
• Ensure all activities are conducted in accordance with company policies, applicable laws, regulations, and compliance requirements.

  Requirements

• Advanced degree required in health economics, health outcome research, epidemiology, public health, pharmacy, biostatistics or a related field; MSc, MPH, PharmD, PhD, or MD.
• 5+ years of industry experience in outcomes research, real-world evidence, medical affairs, market access, health economics, epidemiology, or a related function.
• Strong ability to interpret clinical, real-world, epidemiologic, and economic evidence and translate complex concepts into clear written and verbal communications.
• Demonstrated project management skills, including ability to manage multiple priorities, timelines, stakeholders, and vendor deliverables in a fast-paced environment.
• Collaborative working style with demonstrated ability to operate effectively in a matrixed, cross-functional environment.
• Excellent attention to detail, scientific judgment, communication skills, and commitment to compliant, high-quality execution.
• Ability to manage multiple countries/priorities simultaneously in a fast-paced, evolving environment.
• Ability to work independently and as part of a team.
• Willingness to travel as necessary.
• All applicants must have authorization to work in the US for a company.

Preferred

• Experience in cardiometabolic disease, dyslipidemias, rare disease, RNA interference, or specialty therapeutics.
• High proficiency in R, SAS, Python

California pay range

$180,000—$210,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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