Director Machine Learning, Drug Discovery Analytics

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.The Opportunity:We are seeking a Director Machine Learningto lead the development of advanced machine learning approaches that accelerate small-molecule drug discovery. This role sits at the intersection of data science, chemistry, and biology, transforming complex scientific datasets into predictive models that guide target discovery, compound design, and translational hypotheses.Working closely with experimental scientists, the Director ML will develop cutting-edge modeling approaches that integrate chemical, biological, and phenotypic data with their team. The successful candidate will play a key role in advancing a data-driven discovery strategy by designing predictive models, deploying innovative algorithms, and translating insights into actionable decisions that improve the speed and success of the discovery of medicines for patients with RAS-driven cancers.Key responsibilities include:Scientific Leadership:Provide hands-on scientific leadership in drug discovery analytics spanning Identify opportunities where AI and advanced analytics can meaningfully improve scientific decision-makingManaging, coaching and mentoring scientists across the function in order to develop their skills and build RevMed’s organizational capabilitiesDefine and lead machine learning strategies that accelerate early-stage drug discovery.Model Development:Develop predictive models for:Compound activity, selectivity, ADME/Tox, and developability propertiesTarget engagement, mechanism-of-action, and phenotypic datasetsCross-Functional Collaboration:Work with biologists to interpret complex experimental datasets and generate mechanistic hypotheses.Collaborate with data scientists and engineers and ML engineers to deploy models into scalable discovery workflows.Required Skills, Experience and Education:PhD in machine learning, computational chemistry, computational biology, computer science, or a related quantitative discipline.8+ years experience applying machine learning or advanced analytics to scientific problems.Demonstrated experience working with chemical or biological datasets in drug discovery or related domains.Strong expertise in:Python-based ML ecosystems (PyTorch, TensorFlow, scikit-learn)Data analysis and scientific computing (NumPy, Pandas)Deep learning and representation learning techniquesEvidence of successful coaching, mentorship and development of both individuals and teams in order to build long-term organizational capabilityPassion for scientific innovation and a relentless commitment to improving patient outcomes.Preferred Skills:Proven track record of applying advanced AI/ML approaches (deep learning, generative modeling, structure-based ML) to drug discovery or related life sciences domains.Experience with cheminformatics or bioinformatics toolkits is highly desirable.Familiarity with cloud computing and scalable ML workflows is a plusAbility to work at the interface of computational and experimental science. #LI-Hybrid #LI-LN1The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io Pay Salary Range$273,000—$321,000 USDWe are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to View email address on click.appcast.io so we can share these impersonations with our IT team for tracking and awareness.