Postdoctoral Fellow-MSH-30040-222

Department: Pharmacological Sciences

Physical work location: 1 Gustave L. Levy Place. NY 10029

Name PI or Supervisor:  Lahouaria Hadri, View email address on careers.mountsinai.org

Web link to Lab:

Web link to Department:

Administrative Contact: Yoori Kim, Show phone number, View email address on careers.mountsinai.org

Details of Research Project: 

We are seeking a highly motivated and independent Postdoctoral Fellow to lead hypothesis-driven research focused on the epigenetic and transcriptional regulation of heart and lung vascular diseases. This position is ideally suited for a candidate with a strong background in epigenetics, chromatin biology, vascular biology, or molecular cardiopulmonary research.

The successful candidate will join a dynamic, multidisciplinary research team and contribute to projects aimed at uncovering novel molecular mechanisms underlying pulmonary hypertension, cardiac remodeling, and other lung vascular pathologies. Our work integrates basic and translational science with the goal of identifying therapeutic targets.

Technical Duties: (include any protocols)

Design and conduct molecular and cellular experiments focused on cardiopulmonary disease mechanisms using Primary cell cultures (e.g., endothelial cells, smooth muscle cells), Animal models of vascular and cardiopulmonary disease, Human tissue samples, where applicable, drug screening, and Gene Therapy.

· Apply next-generation sequencing (NGS) techniques, including: ATAC-seq, ChIP-seq, CUT&RUN, RNA-seq, and single-cell omics

· Perform multi-omics data analysis, including epigenomic and transcriptomic profiling.

· Interpret and present research findings in lab meetings, seminars, and at national/international scientific conferences.

· Prepare and submit manuscripts to high-impact, peer-reviewed journals.

· Contribute to the preparation of research grant proposals and progress reports.

Educational and other Requirements for the position: PhD

Experience Required:

Ph.D. in Molecular Biology, Epigenetics, Genomics, or related field.

? Strong background in epigenetic regulation and molecular biology techniques.

? Strong publication record in relevant areas.

? Basic to intermediate skills in bioinformatics and statistical analysis of omics data (e.g., R, Python, or other tools).

? Ability to work independently and manage multiple projects simultaneously.

? Excellent scientific writing, communication, and collaboration skills.

Goals/Outcomes of the Research Project:

Elucidate Epigenetic Mechanisms in cardiopulmonary Disease Pathogenesis and identify key epigenetic alterations that contribute to the development and progression of chronic lung diseases such as pulmonary fibrosis and PAH.

? Integrate Multi-Omics Datasets: Combine epigenomic data with transcriptomic, proteomic, or clinical datasets to build comprehensive molecular profiles and identify therapeutic targets.

? Evaluate the Therapeutic Potential of Epigenetic Modulators using drug and gene therapy.

? Disseminate Novel Findings: Publish results in high-impact peer-reviewed journals, present findings at national and international conferences.

? Support the postdoctoral fellow in developing independent research skills.

SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 858 - Pharmacological Sciences - ISM, Icahn School of Medicine

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About the Mount Sinai Health System:

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes more than 9,000 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics, top 5 in Cardiology/Heart Surgery, and top 20 in Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 11 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.

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Compensation

The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.