Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Director of Scale-up Operations and Engineering (San Diego)

Phykion

About Phykion

Phykion is reimagining aviation fuel. We cultivate hyper-productive microalgae to produce a scalable, low-carbon oil that drops directly into the HEFA pathway — the most commercially established route to sustainable aviation fuel. Our platform is built on three breakthroughs: a field-proven algae host with 5+ years of outdoor cultivation, strain engineering trait stacking that has delivered a 10x gain in oil productivity to date, and an outdoor cultivation process on non-arable land fed by seawater and CO2 . We are scaling this validated technology into demonstration production, paving the way for commercial supply of low-carbon oil by the end of the decade. As part of that scale-up, we are re-opening our pilot facility near Calipatria, California, and building the team that will bring the site back online and run it.

The Role

We are seeking an experienced process engineer to lead the technical re-establishment of the facility and own our downstream process — the dewatering, lysis, and extraction operations that turn cultivated algae biomass into product. Working closely with the Algae Production Lead and the Facilities Supervisor, the Director will stand up equipment, define operating procedures, troubleshoot at scale, and set the technical direction for harvest and downstream processing as the facility ramps. The performance and economics established here will underwrite our path to commercial demonstration.

Duties and Responsibilities

  • Provide general facility oversight and technical direction in close partnership with the Algae Production Lead and the Facilities Supervisor.
  • Own the design, commissioning, operation, and continuous improvement of the downstream process train (dewatering, lysis, extraction, recovery).
  • Lead the facility re-start, including pre-commissioning checks, mechanical and process verification, and performance testing.
  • Translate laboratory and bench-scale recovery processes into pilot-scale operations with an eye toward commercial demonstration; partner with R&D on scale-up experiments and interpretation.
  • Develop mass and energy balances and process flow diagrams; steward SOPs, batch records, and process control approaches for downstream operations.
  • Manage technical scope with external vendors and engineering partners for new installations and modifications.
  • Identify opportunities to reduce production cost and energy intensity and to improve process reliability; lead the resulting capital and operational projects.
  • Champion a strong safety culture; with support from EH&S, ensure compliance with applicable safety, environmental, and regulatory requirements.
  • Help build the pilot team through hiring, training, and development of production and engineering staff.

Requirements and Experience

  • B.S. in Process, Chemical, Mechanical, Agricultural, or related Engineering discipline required; M.S. or Ph.D. preferred. Equivalent education and experience considered.
  • 10+ years of relevant industry experience in process engineering, with technical leadership in downstream bioprocessing, algae or fermentation-based production, food/feed processing, or comparable bio-based manufacturing.
  • Deep, hands-on experience with downstream unit operations — dewatering, centrifugation, filtration, drying, separations, extraction, and product clean-up — at pilot or commercial scale.
  • Demonstrated experience commissioning and starting up process equipment and downstream production lines, ideally including facility re-start, scale-up, or new-facility build-out.
  • Direct experience with algae cultivation and harvest (open ponds, raceways, or photobioreactors) is a plus.
  • Excellent written and verbal communication; able to translate complex technical concepts for non-engineering audiences and communicate clearly with site staff and leadership.
  • Authorization to work in the United States is required.

Work Location and Schedule

On-site at our pilot facility near Calipatria, CA. Standard schedule with flexibility to support a 24/7 operation, including occasional weekend, evening, and on-call coverage during commissioning and campaign runs.

Relocation

Relocation assistance available for qualified candidates relocating to the Calipatria area. The Imperial Valley and surrounding communities offer a range of housing options at attractive cost of living relative to coastal California.

Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Director of Scale-up Operations and Engineering (San Diego) in San Diego, CA vacancy
  • $141.6k - $212.4k

     ...strategic thinking with strong execution, operate independently across a broad range of...  ...The individual must reside in the greater San Diego area and be able to commute to our corporate...  ...Support organizations as they evolve and scale, identifying the organizational... 
    Suggested
    Full time
    Work at office
    Local area
    Monday to Friday
    Flexible hours
    3 days per week

    Illumina

    San Diego, CA
    5 days ago
  • $198.9k - $298.3k

    ## Staff/Director, Product Marketing - IE-IoT (Remote work eligible)San Diego, California, United States of AmericaApply NowFind...  ...technical bridge between internal PDM/Engineering and the external customer...  ...and external partners (OEMs, scaling partners, and distributors) on... 
    Suggested
    Work experience placement
    Remote work
    Work from home

    QUALCOMM, Inc.

    San Diego, CA
    4 days ago
  • $171k - $256.6k

     ...ERP Systems (Record‐to‐Report)San Diego, California, United States of...  ...leading enterprise‐scale financial systems.This role serves...  ...for strategy, delivery, and operational excellence across **General Ledger...  ...multiple business domains (e.g., Engineer, IT, Finance) are being met... 
    Suggested
    Temporary work
    Work experience placement
    Work from home

    QUALCOMM, Inc.

    San Diego, CA
    4 days ago
  • $179.2k - $268.8k

     ...& Systems SolutionsSan Diego, California, United States...  ..., Inc.## **Job Area:**Operations Group, Operations Group...  ...-time onsite work in San Diego, CA (5 days per week...  ..., and built to scale.Our charter spans the full...  ...frameworks and orchestration engines that coordinate work... 
    Suggested
    Full time
    Temporary work
    Work experience placement
    Local area
    Immediate start
    Work from home

    QUALCOMM, Inc.

    San Diego, CA
    4 days ago
  • $184.4k - $276.65k

     ...receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.(Know Your Rights)SummaryLocation: Acton, Massachusetts; San Diego, CaliforniaType: Full time
    Suggested
    Full time
    Work at office
    Remote work

    Insulet Corporation

    San Diego, CA
    4 days ago
  • $180k - $220k

    ~ Director of Golf: AccorHotel in San Diego Director of Golf: AccorHotel in San Diego The Director of Golf position with AccorHotel is a full-...  ...0,000 to $220,000 per year. The position directs golf operations, member service, staff leadership, budgets, revenue goals... 
    Permanent employment
    Full time
    Work at office
    Worldwide
    Shift work

    Golf Worldwide

    San Diego, CA
    4 days ago
  • $171.2k - $256.8k

     ...Technologies, Inc. Job Area: Engineering Services Group, Engineering...  ...based position located in San Diego, CA and is expected to comply...  ...five days per week and operate effectively within a multi‑site...  ...$256,800.00 The above pay scale reflects the broad, minimum to... 
    Temporary work
    Work experience placement
    Work at office
    Immediate start
    Work from home

    Qualcomm

    San Diego, CA
    4 days ago
  • $235k - $260k

     ...as needed Assists in the development of department standard operating procedures, statistical analysis plan and report templates,...  ...Compensation ~ Annual targeted bonus % Work Location: ~ San Diego office. Remote permitted upon approval, with ability to travel... 
    Full time
    Contract work
    Work at office
    Remote work
    Relocation package
    Monday to Friday

    Protego Bio

    San Diego, CA
    5 days ago
  • $154k - $256k

     ...Director, Biology Location: San Diego, CA (onsite) About the job SRT Therapeutics is seeking a Director, Biology to serve as a project team lead within Biology, supporting cross-functional drug development programs from discovery through IND-enabling studies... 

    SRT Therapeutics Inc.

    San Diego, CA
    5 days ago
  • $89.5k - $134.2k

     ...reporting systems.Prepare launch performance summaries that highlight operational issues and functional recommendations for review with the U.S....  ..., or status as a protected veteran.(Know Your Rights)SummaryLocation: Acton, Massachusetts; San Diego, CaliforniaType: Full time
    Full time
    Work at office

    Insulet Corporation

    San Diego, CA
    6 days ago
  • Reference: 629823Posted: 2026-09-22Location: San Diego, CaliforniaCompany: Planet Pharma...  ...****@*****.*** Associate Director, Corporate Counsel, Legal Contracts is...  ...Agreements, Confidentiality Agreements, Operations oriented agreements, and Commercial... 
    Contract work
    Remote work

    Planet Pharma

    San Diego, CA
    7 days ago
  •  ...Director of Veterinary Medicine DVM – San Diego CAAn established small animal practice is seeking an associate veterinarian to join its supportive and collaborative medical team. This opportunity is ideal for a veterinarian who values high-quality patient care, strong... 
    Relocation package

    Desort

    San Diego, CA
    4 days ago
  •  ...maintenance services to communities throughout San Diego County. Since 1971, the organization...  ..., N.N. Jaeschke, Inc. offers strong operational stability, financial longevity, and...  ...compliance. Role Description The Director of Community Management is a full-time,... 
    Full time
    For contractors
    Work at office
    Work from home

    N.N. Jaeschke, Inc.

    San Diego, CA
    5 days ago
  • $85k - $93.6k

     ...Director of Advancement Outside The Lens | San Diego, CA Full-time | $85,000–$93,600 annually Help build the relationships and resources that power youth...  ...OTL has a stronger, more sustainable advancement engine: contributed revenue is growing, relationships are deepening... 
    Full time
    Part time
    Local area
    Flexible hours

    Outside the Lens

    San Diego, CA
    5 days ago
  • $192k - $288k

     ...Utilities VerticalSan Diego, California, United States...  ...across global utility operators.The ideal candidate...  ...and a proven ability to scale businesses through partner...  ..., solutions/customer engineering, product management, and...  ...based position located in San Diego, CA and is... 
    Work experience placement
    Work at office
    Work from home

    QUALCOMM, Inc.

    San Diego, CA
    2 days ago
  •  ...estate investment and development firm, is seeking a Director of Acquisitions in San Diego to help lead the continued growth of its multifamily investment...  ...source and execute transactions ~ Ability to operate strategically while remaining highly involved in underwriting... 
    Work at office

    RETS Associates

    San Diego, CA
    5 days ago
  • $179.2k - $268.8k

     ...Center AI SoftwareSan Diego, California, United States...  ..., Inc.## **Job Area:**Operations Group, Operations...  ...based position located in San Diego, CA and is...  ...Bachelor's degree in Engineering, Information Systems,...  ...throughput, latency, and scaling efficiency.* Experience... 
    Work experience placement
    Work at office
    Work from home

    Qualcomm

    San Diego, CA
    4 days ago
  • $150k - $195k

    Reference: 630393Posted: 2026-09-08Location: San Diego, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** Summary:The Associate Director, Clinical Pharmacology will be responsible for the design, leadership, and implementation... 
    Remote work
    Shift work

    Planet Pharma

    San Diego, CA
    9 days ago
  • $140k - $160k

     ...Senior Project Engineer – Renewable Energy Employment Type: Direct Hire Location: San Diego, California (Hybrid) Compensation: $140,000–$160,000 annually ;...  ...technical coordination and engineering of utility-scale renewable energy projects from development... 
    Hourly pay
    For contractors
    Work at office
    Local area
    Remote work
    Flexible hours

    Suna Solutions

    San Diego, CA
    5 days ago
  • $170.6k - $255.8k

     ...possible.Position Title: Associate Director, Corporate StrategyFunction:...  ...StrategyLocation: San Diego, California (Hybrid). This is...  ...for senior leaders.The role operates across R&D, Product, Commercial...  ..., economics, finance, engineering, life sciences, or a related... 
    Full time
    Apprenticeship
    Work at office
    Local area
    Relocation package
    Monday to Friday
    2 days per week
    3 days per week

    Illumina

    San Diego, CA
    4 days ago
  • $170.6k - $255.8k

     ...and pay for performance. The Associate Director, Pricing will be responsible for creating...  ...needed. The individual must reside in the San Diego area and be able to commute to our...  ...LeadershipPartner with Marketing, Finance, Sales, and Operations to align pricing strategies with... 
    Full time
    Work at office
    Local area
    Monday to Friday
    2 days per week
    3 days per week

    Illumina

    San Diego, CA
    7 days ago
  • $145k - $160k

     ...underrepresented communities throughout San Diego County, providing families in need with...  ...southern region of San Diego, MAAC now operates nearly 40 sites across the county, from...  ...visit: LEADERSHIP & CULTURE The Director of Human Resources will report to Chief... 
    Contract work
    Local area
    Flexible hours

    MAAC

    San Diego, CA
    5 days ago
  • $73 per hour

     ...Technical Program Manager Contract: 12 months On-site in San Diego, CA. This is not a remote role. Rate: Up to $73 per hour (W...  ...A large, well-established US software company with a sizeable engineering organisation. Their data group needs one person to bring order... 
    Hourly pay
    Contract work

    Signify Technology

    San Diego, CA
    5 days ago
  • $179.2k - $268.8k

     ...Linux Platforms and EcosystemSan Diego, California, United States of...  ..., Inc.## **Job Area:**Operations Group, Operations Group Product...  .... You will work closely with engineering, OEMs, independent software vendors...  ...0 - $268,800.00The above pay scale reflects the broad, minimum... 
    Work experience placement
    Local area
    Remote work
    Work from home

    QUALCOMM, Inc.

    San Diego, CA
    4 days ago
  • $40 per hour

     ...time you come to work! As an Assistant Director of Human Resources, you’re not just supporting...  ...hospitality leadership to an iconic San Diego waterfront hotel! Hilton San Diego...  ...decisions that are ready to transition their operational expertise into Human Resources. Union... 
    Local area
    Worldwide
    Night shift

    Hilton Hotels Corporation

    San Diego, CA
    6 days ago
  •  ...Posted: 2026-09-15Location: San Diego, CaliforniaCompany: Planet Pharma...  ...Summary:The Associate Director, Labeling Strategy is responsible...  ...Collaborate with Technical Operations to implement approved...  ...Sciences, Chemistry, Chemical Engineering, or related field required.... 
    Local area
    Remote work

    Planet Pharma

    San Diego, CA
    6 days ago
  •  ...Company Description The Center for Aquaculture Technologies (CAT) operates at the forefront of genetic innovation in the aquaculture...  ...Human Resources Manager is a full-time, on-site role based in San Diego, CA, responsible for leading HR operations and supporting a growing... 
    Full time
    Local area

    The Center for Aquaculture Technologies

    San Diego, CA
    5 days ago
  •  ...Family Health Centers of San Diego is seeking a Supervisor of Human Resources to oversee day-to-day shared services across onboarding, HRIS, benefits and credentialing. You will implement standardized processes, monitor service levels, and produce actionable reports for... 

    Family Health Centers of San Diego

    San Diego, CA
    2 days ago
  •  ...HOW YOU WILL IMPACT OUR MISSION The Director of Human Resources Operations provides strategic and operational leadership for the HR functions that support more than 3,000 team members across San Diego Zoo Wildlife Alliance, including HRIS, Recruiting, Total Rewards... 
    Work at office
    Local area

    San Diego Zoo Wildlife Alliance

    San Diego, CA
    1 day ago
  • $170k - $195k

     ...Us Seawolf Therapeutics is a venture-backed company based in San Diego, CA. We are an innovative and collaborative team developing DNA...  ...: Seawolf Therapeutics is seeking an experienced Associate Director, Analytical Development to lead the analytical function as a... 

    Seawolf Therapeutics, Inc.

    San Diego, CA
    5 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Director of Scale-up Operations and Engineering (San Diego). Be the first to apply!