SRA DNA Encoded Library Technology - (Brisbane, CA)

Company

Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix's dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine's next chapter with a new script to outmatch disease.

Research Associate III/Scientist I, DNA Encoded Library Technology - Nurix Brisbane

Position

We are seeking a talented and motivated chemist to join our Discovery Chemistry team and contribute to the design and synthesis of DNA-encoded libraries (DELs). This hands-on position offers the opportunity to shape Nurix's DEL-based lead discovery platform, working at the interface of chemistry, biology, and automation. Key responsibilities:

• Design and validate novel DEL library builds.
• Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
• Construct DEL libraries to support the in-house library production efforts.
• Work with external partners to support our DEL synthesis and hit follow up strategies.
• Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
• Contribute to platform automation and technology development efforts.
• Present results, document workflows, and contribute to scientific and strategic planning within the Discovery Chemistry organization.

Education and Experience

• B.S. or higher in Chemistry, Biochemistry, or Medicinal Chemistry. 2-5 years of industrial experience (title determined by experience).
• Strong background in synthetic organic chemistry.
• Hands-on laboratory experience synthesizing DNA encoded libraries.
• Familiar with the overall DNA-Encoded Library Technology workflow operations.
• Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).

Added Qualifications

• Experience working in the drug discovery field - drug design, synthesis, and SAR based hit-to-lead optimization.
• Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
• Experience working with molecular biology tools (PCR, qPCR, Western Blot).

Fit with Nurix Culture and Values

• Collaborative and team-oriented, eager to share expertise and learn from others.
• Solution-driven with a hands-on and resourceful approach.
• Adaptable and comfortable in a fast-paced, interdisciplinary environment.
• Committed to scientific excellence and the shared goals of the team.

Location: Brisbane, CA

Salary Range:

RA III: $101,690 - 116,226
SRA: $118,893 - 139,310
Scientist I: $129,382 -146,679

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.

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