Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Lead Simulation Scientist

$130k - $180k

Cambridge Heavy Industries Inc.

Cambridge Heavy Industries (CHI) is building compact, benchtop-scale fusion reactors. Using synchronized multi-ring laser shocks developed over two decades in Prof. Keith Nelson’s lab at MIT, our system achieves more than 400x higher compression efficiency than conventional laser fusion, with off-the-shelf components. Neutrons are our first product, serving markets that pay well before energy breakeven: isotope production (including tritium and medical isotopes), neutron imaging and testing, heat-management qualification, reactor-material testing – with the ultimate goal of energy production. CHI is based at The Engine in Cambridge, MA.

The Opportunity

CHI is hiring a Lead Simulation Scientist to build and own the computational backbone of our fusion platform. You will develop, validate, and apply hydrocode and particle-in-cell (PIC) simulations of laser-driven shock compression, plasma formation, and fusion yield, then turn those results into design decisions for our lasers, targets, and diagnostics. You will work closely with experimentalists, mechanical engineers, and materials scientists, and you will grow the simulation team as CHI scales.

Responsibilities

Hydrocode Simulation

Lead radiation-hydrodynamic simulations of laser-driven, multi-ring shock convergence to predict pressure, temperature, and density histories in the target.

Select, develop, and maintain equation-of-state, opacity, and material-strength models for target materials under extreme conditions.

Use simulation to optimize laser pulse shaping, ring sequencing, and target design for compression efficiency and neutron yield.

Particle-in-Cell Simulation

Lead kinetic and particle-in-cell simulations of laser–plasma interaction, hot-electron generation, and fusion-relevant plasma conditions.

Couple PIC and hydrocode results to capture kinetic effects that fluid models miss, and define when each approach applies.

Validate models against time-resolved experimental data, including high-speed imaging, interferometry, and optical, neutron, or X-ray spectroscopies, and build synthetic diagnostics to guide experiment design.

Partner with experimental, mechanical, and materials engineers to translate simulation results into chamber, target, and laser-system design decisions.

Own CHI’s simulation roadmap and compute infrastructure (HPC or cloud), including code selection, workflows, and verification and validation standards.

Hire and mentor computational scientists as the team grows.

Qualifications

Required

PhD in physics or a related field, with a focus on computational plasma physics, high-energy-density physics, or shock physics.

5+ years of hands-on experience running and developing hydrocodes (e.g., FLASH, HYADES, HELIOS, MULTI, xRAGE, or CTH) for laser-driven or shock-driven problems.

Hands-on experience with particle-in-cell codes (e.g., EPOCH, OSIRIS, VPIC, Smilei, or WarpX) for laser-plasma or kinetic plasma problems.

Track record of validating simulations against experimental data, ideally in shock physics or laser–plasma experiments.

Strong scientific programming skills (e.g., C++, Fortran, Python) and experience running parallel codes on HPC clusters.

Working Style

Versatile. You can wear different hats and thrive in a zero-to-one startup environment.

Builder. You write the first playbook rather than wait for one.

Leader. You set technical direction, mentor others, and explain simulation results clearly to experimentalists and executives alike.

Location

In-person at The Engine, 750 Main Street, Cambridge, MA, with up to 30% travel expected (may change)

Compensation and benefits

Base salary of $130K - $180K plus meaningful early-stage equity.

Medical, dental, and vision coverage

Cambridge Heavy Industries is an equal opportunity employer. We hire and promote on the basis of merit, qualifications, and the company’s needs, and we welcome applicants from all backgrounds.

#J-18808-Ljbffr
Vacancy posted 21 hours ago
Similar jobs that could be interesting for youBased on the Lead Simulation Scientist in Cambridge, MA vacancy
  • Cambridge Heavy Industries (CHI) is hiring a Lead Simulation Scientist to build the computational backbone of our fusion platform in Cambridge, MA. You will develop hydrocode and PIC simulations, validate against experiments, and translate results into design decisions... 
    Suggested

    Cambridge Heavy Industries Inc.

    Cambridge, MA
    2 days ago
  • $146k - $236.5k

     ...company, is seeking a About the Role: FL117, a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations . Here you will build the physics layer of a drug development AI platform. You will characterize how binders... 
    Suggested

    Flagship Pioneering, Inc.

    Cambridge, MA
    1 day ago
  • $112k - $164k

    Job Title:Lead Scientist, Modeling & SimulationJob Description:The Role: Entegris is currently seeking a Modeling & Simulation (M&S) Engineer to join our Digital Solutions Enablement team. In this role, you will perform simulations of products and product derivatives using... 
    Suggested
    Full time
    H1b
    Work at office
    Flexible hours

    Entegris

    Bedford, MA
    4 days ago
  • $119.7k - $222.3k

     ...motivated PK Sciences representative to lead the development and use of artificial intelligence...  ...Drug Disposition (ADME, BA), Modeling & Simulation (M&S), and Operations through PK science...  ..., to be considered for Principal Scientist II. 4+ years of experience to be... 
    Suggested
    Full time

    Novartis

    Somerville, MA
    4 days ago
  •  ...and materials testing. We seek a Principal Fusion Researcher to lead laser-system construction, target design, and experiments in...  ...fast ignition experience, and hands-on laser experience across diagnostics and simulations. #J-18808-Ljbffr Cambridge Heavy Industries Inc.
    Suggested

    Cambridge Heavy Industries Inc.

    Cambridge, MA
    2 days ago
  • $120k - $160k

     ...energy source. We have an opening for an Accelerator Physicist (Lead) who will play a key role in the design and optimization of...  ...for muon focusing and cooling; perform and review beam dynamics simulations. Lead or supervise contractors/vendors for preconceptual linac... 
    Full time
    For contractors

    Acceleron Fusion, Inc.

    Cambridge, MA
    21 hours ago
  • $108.5k - $201.5k

     ...OnsiteLocation: Cambridge, MA, USAWe are seeking a highly motivated PhD scientist with 1-2 years of relevant experience to join a...  ...Therapy, Immunology, Inventory Management, Laboratory Research, Leading Project Teams, Life Science, Machine Learning (ML), Management... 
    Full time

    Novartis

    Somerville, MA
    21 hours ago
  • $100k - $126.5k

     ...to join us!THE ROLEFL111 is seeking an independent and motivated lab scientist with deep understanding of biochemical and biophysical assay design to join the Biochemistry team. This role will lead assay development, target engagement studies, and binding characterization... 
    Contract work
    Shift work

    Seres Therapeutics

    Cambridge, MA
    4 days ago
  • $114.1k - $211.9k

     ...SummaryNovartis Biomedical Research is seeking a highly motivated and scientifically accomplished Translational Biomarker Strategy Lead to serve as the biomarker representative and strategic advisor on DAx project teams.This role will lead the development and execution... 
    Full time
    Local area
    Flexible hours

    Novartis

    Somerville, MA
    21 hours ago
  • $108.5k - $201.5k

     ...biotherapeutic modalities.Job DescriptionInternal Job Title: Principal Scientist I/IIPosition Location:Cambridge, MA, onsiteThe Biologics...  ...a diverse portfolio of biotherapeutic modalities.As a Team Lead for the analytics team, you will demonstrate a broad and in-depth... 
    Full time

    Novartis

    Cambridge, MA
    2 days ago
  • $150.5k - $245.5k

    Oncology Imaging Scientific LeadClinical ImagingBuild our future together:The successful candidate will lead the strategy and execution of complex early and late phase oncology imaging in clinical trials where imaging plays a critical role. Imaging includes all modalities... 
    Full time
    Remote work

    Regeneron Pharmaceuticals

    Boston, MA
    2 days ago
  •  ...objectivity and integrity at our core, we lead federally funded research and...  ...applicants for a Computational Finance (CompFi) Scientist to join our Financial Innovation Laboratory...  ...Department (L144) in the Modeling and Simulation Innovation Center. In FINLab, our Computational... 
    Work experience placement
    Local area
    3 days per week

    Mitre

    Bedford, MA
    4 days ago
  • Flagship Pioneering seeks a Senior/Principal Scientist in Molecular Simulations to lead the physics layer of a drug development AI platform in Cambridge, MA. You will own end-to-end simulation workflows, validate designs before synthesis, and translate results into training... 

    Pioneering Medicines

    Cambridge, MA
    1 day ago
  •  ...A microbiome research firm in Boston is seeking a scientist to drive wet-lab workstreams for generating proprietary datasets. You will lead screening workstreams for stool-derived communities, ensuring data quality and reproducibility. The ideal candidate holds a PhD in... 

    Outpost Bio

    Boston, MA
    3 days ago
  •  ...Integration to develop human-AI interaction tools for challenging work environments in national security and commercial contexts. You will lead and grow teams of researchers, designers, and engineers, define technical work, and build relationships with customers and sponsors.... 

    Innovative Embedded Systems Pvt. Ltd. (SIIC IIT Kanpur).

    Cambridge, MA
    3 days ago
  •  ...Novartis Biomedical Research is seeking a Translational Biomarker Strategy Lead to drive preclinical and translational biomarker strategies from target validation to early clinical planning. This role partners with Biology, In Vitro, In Vivo, Data Science, and Biomarker... 

    Novartis Group Companies

    Cambridge, MA
    2 days ago
  • $50.45 - $67.9 per hour

     ...Beth Israel Deaconess Medical Center to provide oncology laboratory diagnostic services using cutting edge technology. The Lead Genomic Scientist will mentor and lead the Genomic team to establish testing, data analysis and reporting protocols of the acquired genomic data... 
    Hourly pay
    Interim role
    Shift work

    Beth Israel Lahey Health

    Boston, MA
    1 day ago
  • Novartis Institutes for BioMedical Research, Inc. (NIBR) in Cambridge, MA seeks an in vivo scientist to join the Oncology Pharmacology team. You will design and execute in vivo anti-tumor efficacy and PK/PD studies in CDX, PDX, and syngeneic models to advance early drug... 

    U175 (FCRS = US175) Novartis Institutes for BioMedical Resea...

    Cambridge, MA
    2 days ago
  • Broad Institute of MIT and Harvard is seeking a highly motivated computational biologist to lead spatial multiomics data analyses in collaboration with the Getz Lab at Broad and MGH. The role emphasizes developing novel spatial-genomic methods and explaining findings to... 

    Broad Institute of MIT and Harvard

    Cambridge, MA
    3 days ago
  • Flagship Pioneering in Cambridge, MA seeks a Principal Scientist to build FL132’s amyloid research platform from the ground up. This hands-on role interfaces protein biophysics, chemical biology, structural biology, and drug discovery to produce assay‑grade amyloid proteins... 

    Flagship Pioneering, Inc.

    Cambridge, MA
    3 days ago
  • Alnylam Pharmaceuticals (Cambridge, MA) seeks a Principal Scientist to lead DMPK strategies across discovery to clinical development. You will drive PK/PD translational pharmacology, design/interpret ADME studies, and collaborate with cross-functional teams to inform program... 

    Alnylam Pharmaceuticals

    Cambridge, MA
    2 days ago
  • Flagship Pioneering seeks a Principal Scientist to build an amyloid research platform from the ground up in Cambridge, MA. This hands-on...  ...amyloid proteins and qualifying rigorous assays. The candidate will lead experimental strategy, train a team, coordinate CROs, and... 

    Pioneering Medicines

    Cambridge, MA
    2 days ago
  • Sail Biomedicines is seeking a highly motivated Senior Scientist to lead analytics development for RNA drug substances and lipid nanoparticle products. You will drive method development, qualification, validation, and technology transfer while coordinating with Process... 

    Sail Biomedicines

    Cambridge, MA
    2 days ago
  • Takeda in Cambridge, MA is seeking a Senior Scientist, High-Throughput In Vitro ADME to design and scale in vitro ADME assays supporting drug discovery across modalities. You will lead a team within the DAR department, driving assay development, automation integration,... 

    Takeda

    Cambridge, MA
    2 days ago
  • Foundation Alloy Technology Explorations, Inc Cambridge, MA seeks an R&D Group Lead Scientist to head a multidisciplinary team in inventing next‑generation alloys and optimizing their manufacturing. You will execute experimental metallurgy while mentoring early career... 

    Foundation Alloy Technology Explorations, Inc

    Cambridge, MA
    2 days ago
  • Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA, seeks a highly collaborative scientist to lead biology and drug-discovery efforts for novel immune cell engagers and multispecific immune modulators, combining cancer-immunology expertise with cross-functional... 

    U175 (FCRS = US175) Novartis Institutes for BioMedical Resea...

    Cambridge, MA
    21 hours ago
  • Biogen in Cambridge, MA is seeking a Senior Pharmacovigilance Scientist to lead safety signal management, author aggregate reports, review medical literature, and support PV activities in trials and on marketed products. You will mentor staff, collaborate with Global Safety... 

    Biogen

    Cambridge, MA
    2 days ago
  • Novartis Institutes for BioMedical Research, Inc. is seeking a Principal Scientist to lead formulation development for complex biologics, including monoclonal antibodies and ADCs. The role involves guiding a team, shaping early development strategies, and partnering with... 

    U175 (FCRS = US175) Novartis Institutes for BioMedical Resea...

    Cambridge, MA
    2 days ago
  • C4 Therapeutics is seeking a Lead Scientist to oversee biochemical and biophysical assay strategies for the early discovery of targeted protein degraders. The role involves designing and optimizing assays to characterize protein interactions and to drive compound prioritization... 

    C4 Therapeutics, Inc.

    Watertown, MA
    2 days ago
  • Stealth Co in Cambridge, MA seeks a scientifically agile scientist to drive screening and characterization of candidate molecules from our targeted delivery platform, designed to reach a range of targets and tissues. This laboratory-based role will be responsible for designing... 

    Stealth Co

    Cambridge, MA
    2 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Lead Simulation Scientist. Be the first to apply!