Sr. Scientist I- (Biologics Bioanalysis, Characterization and Proteomics Group)

About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. Job Description The Quantitative, Translational ADME Sciences (QTAS) department at AbbVie is seeking a highly motivated scientist to join the Biologics bioanalysis, characterization, and proteomics group. The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and in vitro characterization assays of novel biologics entities. The successful candidate will be experienced in the optimization and implementation of novel and routine LC/MS-based bioanalytical methods to drive in vivo PK, TK, and PK/PD analysis as well as in vitro stability characterization of biotherapeutics. The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation. Key tasks and responsibilities Operate and maintain LC/MS instruments to generate high-quality experimental data. Perform affinity purification of biotherapeutic (including but not limited to monoclonal and multispecific antibody, antibody drug conjugates, antibody-siRNA conjugates, and tLNPs). Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Facilitate assay optimization and implementation to ensure laboratory capacity and data quality. Communicate data interpretation internally and externally. Qualifications Bachelor’s Degree or equivalent education and typically 10 years of experience, Master’s Degree or equivalent education and typically 8 years of experience, PhD and no experience necessary. Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as team player and individual contributor. Prior industry experience in drug discovery/development is preferred. In-depth understanding of in vivo PK, TK and PK/PD studies and corresponding bioanalytical assays as well as in vitro characterization assays is highly desired. In-depth understanding of protein mass spectrometry and hands‑on experience with QQQ (SCIEX), qTOF (Agilent, Bruker, SCIEX) and/or Orbitrap (Thermo) mass spectrometers are highly desired. Hands‑on experience with automated liquid handling systems is highly desired. Demonstrated ability to manage and analyze data using advanced software tools such as Protein Metrics Byos and GraphPad Prism. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our long-term incentive programs. Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer / Veterans / Disabled. US & Puerto Rico only – to learn more, visit US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: #J-18808-Ljbffr AbbVie