Scientist, Large Molecule / Drug Substance

Job Description

Job Description

Job Overview:

Pay Range: $35.00hr - $40.00hr

Requirement/Must Have:

• Ph.D., MS, or BS in Chemistry, Chemical Engineering, Biotechnology, or a related Scientific discipline.
• Experience in liquid chromatography (such as Protein A, CEX, AEX) on AKTA PURE or AVANT system is required.
• Experience with large molecule drug substance manufacturing process is required.
• Knowledge and experience in biologics solution concentration (such as SP-TFF and UF/DF) is required.

Responsibilities:

• Develop, design and perform process development work to support novel biologics purification activities.
• Design and execute experiments in support of upstream and downstream purification development of biologic drugs.
• Propose and develop models that improve the production and purification of selected proteins.
• Contribute to innovation efforts in supporting purification and analysis of proteins and large molecules.
• Contribute to Designs Of Experiments (DOE).
• Participate in a cross-functional team.
• Perform process development studies including determination and characterization of process parameters associated with liquid chromatography, concentration and filtration operations, and viral clearance.
• Apply suitable reduced-laboratory scale models representative of the commercial-scale process.
• Support Process Analytical Technology (PAT) application including active feedback to the processing lines.
• Develop clinical manufacturing process instructions and Process Validation protocols.
• Execute characterization studies relevant to the stage of development.
• Interpret relevant analytical data to drive biologics concentration studies, purification strategies and characterization decisions.
• Handle samples and execute workflows and studies, collect, record, and interpret data appropriately.
• Present data at internal meetings.
• Train and mentor other personnel on techniques and equipment.
• Write technical memos and keep abreast of scientific developments in relevant fields.

Nice to Have:

• Knowledge and experience in protein characterization with a variety of standard analytical methods (Raman, A280, ProG, SEC, NIR, etc.).
• Experience in protein purification.
• Experience in filter sizing including depth, sterile and nano filtration.
• Experience in Resin Lifetime Studies.
• Experience with GMP processes.
• Strong verbal and written communication skills.
• Ability to communicate effectively with stakeholders.

Skills:

• Liquid chromatography.
• AKTA PURE.
• AKTA AVANT.
• Protein purification.
• SP-TFF.
• UF/DF.
• Large molecule drug substance.
• Design of Experiments (DOE).
• Process Analytical Technology (PAT).
• Viral clearance.
• Protein characterization.

Qualification And Education:

• Bachelor's degree or higher in a scientific discipline.

Benefits:

Our Benefits Include:

• Medical, Dental, and Vision Insurance
• 401(k) Retirement Plan
• Health Savings Account (HSA)
• Disability Insurance (Short-Term and Long-Term)
• Life and AD&D Insurance
• Paid Sick Leave (where required by applicable state or local law)
• Supplemental Insurance Plans
• Identity Theft Protection
• Pet Insurance
• Employee Wellness Programs
• Employee Assistance Program (EAP)
• Career Growth and Professional Development Opportunities

Disclaimer : Benefits eligibility, accrual rates, and usage limits may vary based on employment status, length of service, and work location. Paid Sick Leave is provided in strict accordance with applicable state and municipal mandates. Cynet Systems Inc. reserves the right to modify, amend, or terminate any benefit plans at any time in accordance with applicable laws.

About Cynet Systems

Founded in 2010 and headquartered in the Washington, DC metro area, Cynet Systems Inc. is a leading technology staffing and workforce solutions company serving Fortune 500 companies, government agencies, and enterprise organizations across the United States and Canada. We deliver agile, scalable talent solutions across IT, engineering, life sciences, clinical, and professional staffing, powered by a high-performing recruitment engine operating across North America and Asia.

As a nationally and locally certified Minority Business Enterprise (MBE), Cynet Systems is committed to helping organizations build high-performing teams while empowering professionals to grow rewarding careers. Our organization is certified to ISO 9001, ISO 14001, ISO 27001, and SOC 2 Type II standards, reflecting our commitment to quality, security, operational excellence, and customer success.