Principal Scientist, Oligonucleotide Manufacturing
Amgen SA
Amgen is seeking a Principal Scientist in Oligonucleotides to lead development of sustainable manufacturing processes at either Thousand Oaks, CA or Cambridge, MA. You will drive capacity expansion, technology transfers, and innovation within the oligonucleotide program, mentoring staff and guiding cross-functional teams.
The role requires a PhD/MD/PharmD with relevant experience and a strong track record in industrializing oligonucleotide processes, with opportunities to influence regulatory
#J-18808-Ljbffr$141.84k - $191.9k
...the lives of patients as we research, manufacture, and deliver innovative medicines to... ...while transforming your career.Principal Scientist OligonucleotidesWhat you will doLet’... ..., and lead technology transfers for oligonucleotides. The candidate will drive technology...PrincipalFull timeFlexible hours- ...the lives of patients as we research, manufacture, and deliver innovative medicines to... ...career. Process Development Senior Principal Scientist Bioconjugates What you will do Let... ..., and lead technology transfers for oligonucleotides. The candidate will drive technology...PrincipalFlexible hours
- ...Amgen seeks a Principal Scientist to lead oligonucleotide process development and manufacturing innovation within the Process Development group. The role involves directing multidisciplinary teams on sustainable manufacturing processes, capacity expansion, and technology...PrincipalContract work
$108.5k - $201.5k
...to transform patients’ lives around the world. As a Principal Scientist I or II, Oligonucleotide Chemistry and Innovation, you will play a critical role... ...procedures supporting reproducible oligonucleotide manufacturing processes.Operate, troubleshoot, and maintain...PrincipalFull timeLocal areaWorldwideFlexible hours- ...pharmaceutical business focused on specialty products. We develop, manufacture, sell and market high-quality products exclusively for... ...the world. Job Purpose The Regulatory Affairs Senior Principal Scientist leads and delivers thoughtful, forward-looking regulatory...Principal
$188k - $259k
About This Role Biogen is seeking a Sr. Principal Scientist, Oral Drug Product Development to provide scientific and strategic leadership... ...typically low solubility and low permeability compounds, clinical manufacturing readiness, technology transfer, and commercialization. The...PrincipalFull timeTemporary workLocal area$145.5k - $218.3k
Job DescriptionGeneral Summary:The Principal Scientist Aseptic Control is recognized as having expertise in the principals and application... ...processing technologies and providing technical support for manufacturing of cell and gene therapy (C>), small molecule, and...PrincipalFull timeContract workSummer workRemote workFlexible hours2 days per week$122.25k - $176.58k
...Waltham, MA Full time R2857588 Job title : Principal Scientist ~ Location: Waltham, MA About the Job The Genomic Medicine... ...Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced...PrincipalFull time- Role Lead formulation development and manufacturing scale-up for small molecule oral drug candidates in early clinical stages. Responsibilities design, optimize, and scale robust formulations aligned with target profiles oversee process development, technology transfer,...Principal
$179k - $236k
...leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method... ...lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver-directed lipid...Principal$179k - $236k
...on scientific leader. We are looking for an accomplished DMPK scientist with experience in PK and PK‑PD study design, PK data... ...lead program, AP003, is a chemically modified, engineered tRNA oligonucleotide encapsulated in a clinically validated, liver‑directed lipid...Principal$138k - $207k
...Pharmaceuticals is seeking a highly experienced and motivated Principal Scientist to join the Vertex Manufacturing Center (VMC) Kilo Lab in a dual-capability role... ..., MS) to drive process decisionsBuild Peptide and Oligonucleotide Purification Capability: Define the strategic...PrincipalFull timeSummer workFlexible hours$136.8k - $167.2k
...Development Group as part of the larger Oligonucleotide and Lipid Process Sciences team within... ...with external manufacturing & supply chain as well as CDMOs in support... ...molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders that...Full time$108.5k - $201.5k
...biotherapeutic modalities.Job DescriptionInternal Job Title: Principal Scientist I/IIPosition Location:Cambridge, MA, onsiteThe Biologics... ...biologics modalities, e.g. multispecific Abs, AAV, ADCs, oligonucleotides, CAR-T’s. This entails the evaluation of novel instrumentation...PrincipalFull time- ...Somerville, MA to perform small-scale, high-throughput production of guide RNA and optimize synthesis/purification methods for scalable manufacturing. You will collaborate with the Internal Manufacturing team during process transfer and participate in cross-functional teams...
- ...Germany. JOB OVERVIEW We are seeking a dynamic and experienced Principal Scientist/Associate Director, Clinical Biomarkers to join our... ...biomarker strategies to support the clinical development of our oligonucleotide-based therapeutics. The ideal candidate will bring deep...Principal3 days per week
- Overview We are seeking an experienced and highly motivated Principal Scientist, Biotransformation & Metabolite Profiling to provide... ...industry research experience in small molecule, peptide, oligonucleotide, RNAi development. Extensive hands‑on experience in drug...PrincipalLocal area
$145.5k - $218.3k
...Vertex Pharmaceuticals seeks a Principal Scientist with deep expertise in aseptic processing technologies for sterile drug manufacturing. This technical leader will develop microbial control strategies, support manufacturing investigations, and ensure compliance with regulatory...PrincipalContract work- A leading organisation is seeking a Scientist III (R&D) to join its Oligonucleotide/Peptide Purification Development team in Cambridge, MA. This onsite... ...therapeutics, supporting both clinical and commercial manufacturing.The Scientist III will be responsible for developing...
$117k - $158.2k
Overview:The Scientist, Biocatalysis & Protein Engineering will discover, engineer, characterize, and optimize biocatalysts for oligonucleotide and small-molecule manufacturing processes. The successful candidate will develop and apply protein engineering strategies, high...Full timeTemporary workLocal areaFlexible hours- ...UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...Principal
- ...Pioneering Intelligence is seeking a Senior Principal Scientist to invent and build the next generation of evolutionary algorithms for autonomous science. In this senior IC role, you will develop methods that enable populations of models to evolve over time through iterative...Principal
- Pioneering Intelligence is building AI systems that accelerate translational decision making across Flagship’s portfolio. This forward-deployed role bridges capability to impact by applying PI technologies to translational challenges and business decisions. The successful...Principal
$66.8k - $124k
...platform for the LGBTQ+ business community. Please do not contact the recruiter directly. Summary Job Title: Research Scientist I or II, Oligonucleotide Chemistry #LI-Onsite Location: Cambridge, USA Relocation Support: This role is based in Cambridge, USA....Local areaRelocation packageFlexible hours$208k - $286k
...Flagship Pioneering is looking for a Principal Scientist specializing in Machine Learning to lead AI projects that impact early-stage ventures. Ideal candidates will possess a strong background in AI/ML and hold a Master’s or PhD. Responsibilities include overseeing technical...Principal- ...Barrington James is partnering with a well-funded clinical-stage biotech startup in Boston seeking a Principal Scientist – Computational Biology to own the computational strategy for a cell therapy project. You will build pipelines from scratch, define analytical standards...Principal
- ...BMS is seeking a Principal Scientist in Translational Informatics and Predictive Sciences to apply computational, bioinformatics, and ML approaches to large-scale clinical and real-world datasets in solid tumor oncology. You will analyze data, build predictive models,...Principal
- ...Zealand Pharma in Cambridge, MA seeks a Principal Scientist to lead the DMPK/ADME strategy for complex drug modalities and to build discovery platforms and bioanalysis capabilities. You will shape strategy, culture, and technical excellence from the ground up. You will...Principal
- ...Stoke Therapeutics seeks a Senior Scientist to develop sterile oligonucleotide drug products and manufacturing processes. The role involves formulation design, characterization, process optimization, and collaboration with contract manufacturers to support the company...Contract work
- ...Kernal Biologics, Inc. is seeking a Principal Scientist, Analytical Development for its Boston hub. You will lead design, development, and execution of analytical methods to support the mRNA platform and in vivo CAR-T programs, with emphasis on biophysical characterization...Principal
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