Associate Researcher II - Hematology & Medical Oncology

Description The Associate Researcher II will work in the laboratory of Hanna Irie and will be engaged in translational breast cancer research projects focused on regulators of growth, survival and drug resistance, as well as the tumor microenvironment. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breast cancers, particularly triple negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple negative breast cancers. The researcher will utilize patient‑derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immune microenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overall maintenance of the laboratory. Responsibilities Conduct experiments using advanced research techniques specific to subject matter of the research project. Analyze and assist in interpreting moderately complex results. Perform assays to support research studies. Assist in new and unexpected research experiments and techniques. Assist in the collection, analysis and review of experimental data for publication and presentation. May train less‑experienced research staff and postdoctoral fellows in research techniques and use of equipment. Perform other related duties. Technical Duties Cell culture Western blot Cell viability assays qPCR DNA preparation (bacterial transformation, DNA extraction, transfection) Lentivirus production Mouse handling – tumor cell injections, mouse surgeries, IVIS imaging Flow cytometry Organoid development and culture Microscopy Lab record keeping Contribute to laboratory maintenance Qualifications Bachelor's Degree in sciences or related field or equivalent experience 2 years in a research environment or 1 year plus Master's Degree in sciences or related field Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred Compensation The Mount Sinai Health System (MSHS) provides salary ranges that comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $66,482.07 - $84,560 annually. Actual salaries depend on a variety of factors, including experience, education, and operational need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits. Equal Opportunity Employer The Mount Sinai Health System is an equal opportunity employer, complying with all applicable federal civil rights laws. We do not discriminate, exclude, or treat individuals differently based on race, color, national origin, age, religion, disability, sex, sexual orientation, gender, veteran status, or any other characteristic protected by law. We are deeply committed to fostering an environment where all faculty, staff, students, trainees, patients, visitors, and the communities we serve feel respected and supported. Our goal is to create a healthcare and learning institution that actively works to remove barriers, address challenges, and promote fairness in all aspects of our organization. #J-18808-Ljbffr Mount Sinai Morningside