Procurement and Vendor Operations Senior Manager

Job Description Position Summary We are seeking an experienced and detail-oriented Senior Manager to support Procurement Operations and Vendor Management within Vertex's BPO-enabled operating model. Reporting to the Associate Director, the Senior Manager will play a critical role in overseeing BPO-delivered activities, monitoring performance against SLAs, enforcing procurement policy compliance, and driving continuous improvement across outsourced procurement workflows. This role requires a strong operator with excellent analytical and communication skills, and the ability to collaborate effectively with business stakeholders, Finance, Internal Controls, Category Management, and the external BPO partner. This role also supports operational execution across Procurement Req-to-PO, Service Desk and Vendor Master Data Management activities delivered through the BPO, serving as an operational nerve center within the retained model. This role does not own enterprise policy, vendor contracts, or audit accountability, but plays a critical role in surfacing risks and driving operational improvements. Key Responsibilities BPO Operations Oversight Oversee day-to-day BPO-delivered procurement operations, including requisition review, PO creation, change orders, and catalog enablement, procurement service desk support, and vendor master data management. Monitor BPO performance against SLAs and KPIs (e.g., cycle time, touchless PO rate, policy compliance rate); identify performance gaps and support remediation planning. Monitor volumes, backlog, aging, and quality to ensure operational stability and consistent service delivery. Participate in service reviews and governance forums, including operational performance meetings and QBRs. Serve as the primary day-to-day contact for offshore delivery leads, run operational calls, track performance issues, and drive resolution. Policy & Process Compliance Ensure adherence to procurement policies, approval matrices, and buying channel strategies across all BPO-delivered activity. Monitor maverick spend, identify root causes, and drive sustainable compliance improvements. Partner with Category Management to ensure operational execution aligns with sourcing strategies. Support training and communications on procurement tools, processes, and policy updates. Escalation & Issue Resolution Serve as an escalation point for complex vendor, requisition, and PO issues not resolved at the BPO level. Partner with business stakeholders, Procurement, and Accounts Payable teams to resolve urgent operational issues and maintain executional alignment in a timely manner. Coordinate with the BPO to investigate root causes of defects, delays, vendor or user complaints, and implement durable solutions, corrective actions, clarifications, and process handoff improvements. Escalate systemic or high-risk issues to the Associate Director as appropriate. Performance Reporting & Analytics Track and report on procurement operations metrics, including cycle time, exception rates, and catalog adoption. Use reporting tools such as BI platforms and Excel to generate operational dashboards and insights. Identify trends, risks, improvement opportunities and surface recommendations to the Associate Director. Continuous Improvement & Digitization Drive catalog adoption, self-service enablement, and guided buying compliance initiatives. Identify opportunities to simplify procurement workflows and reduce manual interventions. Support automation and digitization initiatives in partnership with the BPO. Risk & Controls Ensure appropriate controls are embedded within requisition-to-PO workflows. Support audit and compliance activities related to procurement operations. Identify operational risks and escalate mitigation strategies as appropriate. Team Support & Development Foster a culture of collaboration, accountability, and continuous improvement within the team. Conduct regular performance reviews and provide coaching to support professional growth. Support onboarding and training on procurement systems and processes. Education and Experience 5–8+ years of experience across Procurement Operations and Vendor Management, with demonstrated experience in Procure-to-Pay execution and vendor oversight Experience managing outsourced procurement operations and vendor relationships required, including performance oversight and governance Experience working in a BPO-enabled or shared services model preferred Hands-on experience in Req-to-PO, Procurement Service Desk, and Vendor Master processes Professional certification (e.g., CPSM, CIPS) preferred Continuous improvement experience (Lean/Six Sigma) a plus Skills and Competencies Strong understanding of end-to-end Procure-to-Pay processes, policies, and best practices. Knowledge of procurement systems, guided buying platforms, and ERP systems (e.g., Oracle, Coupa) and service desk/work management tools. Proficiency in data analysis and reporting tools (e.g., BI platforms, Excel). Strong stakeholder management and change management capabilities. Analytical mindset with the ability to interpret operational metrics and translate them into actionable improvements. Exceptional communication and interpersonal skills to effectively manage teams and collaborate with stakeholders. Proven ability to work under pressure, meet deadlines, and manage multiple priorities. Strong operational discipline, prioritization, and problem-solving skills. Key Attributes High level of integrity and commitment to compliance, accuracy, and operational excellence. Results-driven with a focus on continuous improvement and value realization. Collaborative and adaptable, with a global mindset and the ability to work across diverse teams and cultures. Proactive in identifying and escalating issues to appropriate stakeholders. Strong business acumen and ability to align procurement operations with organizational objectives. #LI-AA1 #LI-Hybrid Pay Range: $134,400 - $201,600 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; or select 2. On-Site: work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. #LI-Hybrid Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion-dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1-mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha-1 antitrypsin deficiency . Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.