Post-Doctoral Research Scientist - Lymphoma Translational Therapeutics andB-cell Immunology

Job details About Us: The people of Memorial Sloan Kettering Cancer Center (MSK) are united by a singular mission: ending cancer for life. Our specialized care teams provide personalized, compassionate, expert care to patients of all ages. Informed by basic research done at our Sloan Kettering Institute, scientists across MSK collaborate to conduct innovative translational and clinical research that is driving a revolution in our understanding of cancer as a disease and improving the ability to prevent, diagnose, and treat it. MSK is dedicated to training the next generation of scientists and clinicians, who go on to pursue our mission at MSK and around the globe. Lue Lab (Department of Medicine) & Chaudhuri Lab (Sloan Kettering Institute, Immunology Program) Dr. Lue is a physician-scientist and maintains an active practice as a medical oncologist treating patients with lymphoid malignancies. Dr. Chaudhuri is a Professor in the Immunology Program at Sloan Kettering Institute whose lab studies B-cell immunology and diversification. The Lue and Chaudhuri laboratories are jointly recruiting a post‑doctoral research scientist with a strong interest in basic and translational research at the interface of lymphoma biology, molecular biology, and immunology. The successful candidate will lead projects in two interconnected areas:

1. Novel Protein Degraders in B‑Cell Malignancies: Investigating the application and mechanism of action of targeted protein degraders in lymphoid cancers, with a focus on characterizing emerging patterns of therapeutic resistance.
2. Cell Membrane Transporter in Drug Resistance and Germinal Center Biology: Our groups have recently discovered a membrane transporter with potential roles in drug resistance in B‑cell lymphomas and direct physiological relevance to normal germinal center function. The candidate will pursue mechanistic studies to define its biological significance in both contexts.

The research program integrates standard and advanced molecular biology, biochemistry, bioinformatics (including RNA‑seq and multi‑omic analyses), and in vivo mouse modeling. The candidate will work within a highly collaborative environment and have opportunities to: Interact with investigators across lymphoma biology, immunology, and translational therapeutics at Memorial Sloan Kettering Contribute to correlative science associated with active clinical trials Develop skills bridging fundamental discovery and clinical application Qualifications: PhD, MD/PhD, or equivalent doctoral degree in biological sciences Strong background in molecular biology and tumor biology, with particular interest in lymphoid malignancies Demonstrated proficiency in molecular and biochemical techniques, including DNA, RNA, and protein assays Experience with mouse models of cancer or immunity Familiarity with RNA‑seq or other next‑generation sequencing workflows Experience handling and processing biospecimens Preferred: Prior research experience in B‑cell biology, lymphoma, or immunology Computational or bioinformatics skills for genomic data analysis Track record of productivity Ability to work both independently and collaboratively in a multidisciplinary team Additional Requirements: A cover letter describing research interests and career goals Curriculum vitae, including a full publication list Contact information for three references Salary Range: $72,000 - $74,000 Closing: At MSK, we believe in fair, competitive pay that reflects your job, experience, and skills. MSK is an equal opportunity and affirmative action employer committed to diversity and inclusion in all aspects of recruiting and employment. All qualified individuals are encouraged to apply and will receive consideration without regard to race, color, gender, gender identity or expression, sexual orientation, national origin, age, religion, creed, disability, veteran status or any other factor which cannot lawfully be used as a basis for an employment decision. Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please let us know if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment. #J-18808-Ljbffr Memorial Sloan