Head of Cell Line Development
Scorpion Therapeutics
Head of Cell Line Development (Director) Responsibilities: Define CLD vision, platform strategy, and roadmap aligned to portfolio demand. Lead, coach, and develop a team (~10) for clinical cell line delivery and technology evaluation. Own functional budget, cell line timelines, and vendor governance (CRO/CDMO support as needed). Provide end-to-end oversight of mammalian cell line development: vector/transfection strategy, selection systems, single-cell cloning, clone screening, stability assessment, and nomination. Ensure fit-for-purpose characterization packages (growth, productivity, stability, product quality) with upstream process development. Lead risk-based strategies for difficult-to-express/complex molecules (e.g., bi-specifics). Ensure robust documentation (cell line history, clonality rationale, traceability, data integrity) to support filings/audits; contribute to IND/IMPD submissions. Accountable for cell banking strategy/execution, including GMP readiness for MCB/WCB generation and compliant handoffs/documentation. Evaluate and implement new CLD technologies (host cell/selection systems, single-cell tools, automation, analytics, digital/AI-enabled screening) and ensure platform fit. Build external collaborations with technology providers and academic/industry partners. Qualifications: Recognized expert in Cell Line Development with a track record delivering clinical production cell lines and strong tech transfer packages. Deep expertise in cell biology, host cell engineering, and expression vector design. Strong understanding of CLD impact on product quality/manufacturability (esp. bi-specifics/complex proteins). Expert in influencing; manage in a matrix environment; collaborate cross-functionally with senior stakeholder communication. Extensive experience leading/coaching scientists and driving career development. Experience supporting commercial cell lines and lifecycle management (investigations, comparability/change control) including regulatory/quality requirements for MCB/WCB and IND/BLA. Demonstrated success with automation/high-throughput screening and improving cycle times. Expert troubleshooting; solves strategic problems and coaches others. #J-18808-Ljbffr Scorpion Therapeutics
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