Front Line Manufacturing Manager (Bulk Drug Substance - Downstream) - Night Shift

Amgen seeks a Front Line Manufacturing Manager for night shift operations at its advanced drug substance facility in Holly Springs, North Carolina. This role involves overseeing manufacturing teams on a 12-hour rotating schedule, ensuring GMP compliance, driving continuous improvement, and developing staff while maintaining safe, efficient production operations.

Responsibilities

• Oversee manufacturing teams on 12-hour night shift rotation producing GMP drug substances
• Champion safe, compliant production environment and lead continuous improvement initiatives
• Recruit, train, coach, develop and evaluate staff; ensure adherence to production schedules
• Collaborate with cross-functional teams on process execution, problem-solving, and CAPA development
• Ensure regulatory compliance, proper gowning/aseptic techniques, and workplace safety standards

Requirements

• Previous managerial experience directly managing people or leading teams and projects
• Bachelor's degree in Life Sciences or Engineering preferred
• 5+ years process experience in cGMP manufacturing facility preferred
• 3+ years experience in production Area Lead, Specialist, or Manager role preferred
• Strong leadership, coaching, mentoring, and team-building skills
• Understanding of downstream purification operations and cGMP/CFR regulatory compliance