Manager - US Mainframe Applications

Work ScheduleStandard (Mon-Fri)Environmental ConditionsOfficeJob DescriptionManager, Mainframe ApplicationsOnsite – Pittsburgh, PAAbout the RoleAs part of the Thermo Fisher Scientific team, you’ll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life every single day to enable our customers to make the world healthier, cleaner, and safer. We provide our teams with the resources needed to achieve individual career goals while helping to take science a step beyond.Thermo Fisher Scientific is seeking a Manager, Mainframe Applications to lead and support mission-critical mainframe systems that underpin key business operations. This role is responsible for the day-to-day management of mainframe application support and delivery, including people leadership, operational stability, and project execution. The successful candidate will balance hands-on leadership with strategic thinking, ensuring existing systems remain reliable while supporting ongoing modernization efforts.This position is onsite in Pittsburgh, PA and supports primarily U.S.-based business operations.Key ResponsibilitiesLead and develop a team of mainframe application professionals, including full-time employees and contingent resourcesOversee day-to-day support of production mainframe applications, ensuring high availability, performance, and timely issue resolutionManage and prioritize enhancement, maintenance, and project work, including direct management of select application projectsServe as a primary technology partner to business stakeholders, translating business needs into effective technical solutionsEnsure effective development, testing, deployment, and ongoing maintenance of mainframe applicationsProvide leadership and oversight for systems utilizing IDMS databases, VSAM files, and related mainframe technologiesSupport modernization initiatives, including system enhancements, technical debt reduction, and integration with distributed or cloud-based platformsCollaborate closely with architecture, infrastructure, security, QA, and other IT teams to ensure aligned deliveryManage vendor and contractor relationships, including performance oversight and deliverable managementEnsure compliance with internal controls, security standards, and regulatory requirementsContribute to budgeting, forecasting, and resource planning for mainframe applicationsFoster a culture of continuous improvement, operational excellence, and accountabilityRequired QualificationsBachelor’s degree plus 8 years of relevant IT experience, or Advanced degree plus 6 years of experienceMinimum of 3+ years in a people management or technical leadership roleSignificant experience working in mainframe application environmentsStrong working knowledge of IDMS databases, VSAM files, and mainframe application supportDemonstrated ability to manage both operational support and project delivery concurrentlyProven experience partnering with business stakeholders and leading cross-functional initiativesStrong communication, leadership, and decision-making skillsPreferred QualificationsExperience managing hybrid teams with both employees and contractorsExposure to mainframe modernization or system transformation initiativesFamiliarity with SDLC methodologies (Agile, waterfall, or hybrid)Experience working in regulated environments (e.g., GxP, FDA)Industry certifications such as ITIL, PMP, or AgileExperience with enterprise integration and modern IT architecturesTravel may be required up to 25%Job SummaryJob number: R-01341892Date posted : 2026-03-05Profession: IT, Data & TechEmployment type: Full time