Head of Finance (Remote)

Job Description We are seeking a Senior Director / Director to lead the Value Realization Office (VRO) process for material, transformational initiatives across the project lifecycle. This role partners closely with project owners, executive sponsors, Finance, and DTE to define how value will be measured, establish baseline and reporting approaches, and monitor realized value against agreed objectives. The position is central to building a disciplined, consistent approach to value delivery, helping ensure strategic initiatives achieve measurable outcomes and addressing risks or variances when performance is off track.

What You’ll Do Lead execution of the Value Realization Framework for in-scope, material, and transformational initiatives.

Partner with project owners and key stakeholders to define success metrics, baseline methodology, and reporting approaches that support clear and credible value measurement.

Facilitate VRO intake and kickoff activities, reviewing initiative materials such as current state, target state, cost to achieve, ownership, dependencies, and expected outcomes.

Confirm sign-off criteria for success metrics, target or baseline values, reporting cadence, measurability confidence, and accountability before initiatives move into ongoing monitoring.

Establish and maintain a structured governance and reporting cadence, including regular review of initiative scorecards and reporting packages.

Evaluate measurability confidence for each metric and ensure assumptions, confidence levels, and Finance validation are documented where applicable.

Escalate material risks, unresolved gaps, and value delivery variances, and support corrective action, re-baselining, closeout, or extension decisions as needed.

Drive adoption of consistent value measurement practices across financial, operational, risk/compliance, decision support, and workforce-related outcomes.

Minimum Qualifications Bachelor’s degree in finance, accounting, or a related field.

Significant experience in finance, strategic planning, transformation, program leadership, PMO leadership, reporting, or related business functions.

Demonstrated strength in budgeting, forecasting, long-range planning, financial modeling, reporting, variance analysis, or executive decision support.

Experience building governance structures, reporting cadence, accountability models, and measurable business outcomes for complex initiatives.

Strong knowledge of performance measurement, success metrics, baseline methodology, and variance review.

Preferred Qualifications Advanced degree in finance, accounting, or a related discipline.

Experience serving as a finance business partner to senior leadership.

Experience operating in complex regulatory, operational, or highly matrixed environments.

Experience driving organizational change management, milestone alignment, and risk mitigation for large-scale transformation efforts.

Experience building or applying structured frameworks for value measurement across financial value, operational performance, risk/compliance, decision quality, and workforce experience.

Why This Role This is an opportunity to help shape how value is defined, measured, and delivered across high-impact initiatives. The role offers broad cross-functional exposure and the ability to influence strategic, financial, and operational outcomes through disciplined governance, strong partnership, and measurable business impact.

This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.

From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation Hybrid-Eligible Or On-Site Eligible

Hybrid: work remotely up to two days per week.

On-Site: work five days per week on‑site with ad hoc flexibility.

Flex Eligibility Status In this Hybrid-Eligible role, you can choose to be designated as: 1. Hybrid: work remotely up to two days per week; On-Site: work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io.

Help Us Achieve Our Mission Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life-shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion‑dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1‑mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha‑1 antitrypsin deficiency. Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit or follow us on Facebook, Twitter/X, LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. J-18808-Ljbffr Vertex Pharmaceuticals LLC