Science and Research Biologist

Target PR Range: 37-47/hr DOE

Job description

We are seeking a highly motivated and skilled scientist to join our Immunology Discovery team in Worcester, MA. In this role, you will collaborate with multiple cross-functional teams to advance portfolio projects, with a core focus on human intestinal organoid biology, ex vivo tissue processing, and cell-based in vitro assay execution. Responsibilities span the full experimental cycle from assay design and execution to data analysis and cross-team communication across diverse and technically demanding cell systems.

This position offers a unique opportunity to work at the interface of basic research and early drug discovery in a fast-paced, multidisciplinary environment. The ideal candidate brings hands‑on expertise in primary cell culture, 3D cell models, immunoassays, and molecular biology techniques, and thrives both independently and within a collaborative team setting.

Key responsibilities

Culture, passage, and plate human intestinal organoids to support the group’s research objectives.

Perform assays in primary 3D cell culture models such as Transwells or MPS/CIVM platforms.

Test biologic and small molecule compounds in cell-based assays for functional readouts, including cell proliferation, cytokine release, and gene expression.

Execute advanced molecular and cellular biology techniques, including but not limited to flow cytometry (FACS), ELISA, MSD, and qPCR.

Process human tissue ex vivo and isolate organoids, fibroblasts, and immune cells from human tissue or blood.

Work independently on the design, execution, and interpretation of experimental results to validate project‑relevant hypotheses.

Maintain close communication with multiple teams to support human intestinal organoid cell needs.

Implement and innovate new experimental protocols and techniques as needed.

Analyze, interpret, document, and report data consistently, concisely, and rigorously, both to individual stakeholders and in group settings.

Demonstrate scientific excellence through dedicated contributions to multiple projects in a fast‑paced, multidisciplinary environment.

Drive project impact primarily through hands‑on, lab‑based activities.

Qualifications and requirements

Required skills

Bachelor’s degree in Biological Sciences or a related field, with 4+ years of experience in an industry setting.

In vitro cell culture experience, including sterile techniques and handling of challenging cell types.

Experience working with primary human organoids.

Comfortable handling with ex vivo human tissue and processing.

Experience with 3D cell culture models such as transwells or MPS/CIVM platforms.

Proficiency in ELISA, MSD or Luminex.

Ability to learn new skills and apply them in a fast‑paced research environment.

Excellent oral and written communication skills with a collaborative mindset.

Comfortable managing, shifting timelines and evolving work priorities.

Ability to work both independently and as part of a team.

Strong creativity, problem‑solving skills, and attention to detail.

Skills that are a plus

Experience with cell‑based assay development.

Proficiency in multi‑color flow cytometry.

Experience with gene expression analysis by qPCR.

Experience working with fibroblasts and immune cells, including T cells, B cells, and monocytes.

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