Head of Operations & Business Management
$220k - $240kEncoded Therapeutics
Encoded Therapeutics Inc. is a biotechnology company advancing precision medicines for a broad range of genetic disorders. Our mission is to unlock new opportunities for viral gene therapy through genomics-driven discovery. We focus on delivering life-changing advances for individuals with genetic disorders not addressable with current approaches. Encoded is seeking a Director, Total Rewards & Operations. As Encoded scales, the People function must mature its compensation and equity programs, modernize its HR systems and operations, and establish the robust data integrity and compliance frameworks required of an expanding, multi-site organization. The Director, Total Rewards & Operations will own that build.
The right person is a total rewards practitioner with real compensation design depth who also has the operational instinct to architect systems, lead vendor relationships and transitions, and stand up scalable controls and compliance rigor. They will be a key partner to Finance, Legal, and the People & Culture leadership team, and a credible counterpart to our external compensation consultants, brokers, and auditors.
The defining feature of this role is build and scale - evolving Encoded's compensation, equity, and HR-operations infrastructure, including its HR technology and service-delivery model, to support the company's growth and increasing organizational maturity.
Partner with the VP, People & Culture and the Board's Compensation Committee to design and implement scalable, market-competitive executive and broad-based incentive structures appropriate to a maturing organization.
Partner with Finance on the design and market-competitiveness of the equity program - including grant guidelines, benchmarking grant levels against market, and the evaluation of future equity vehicles (e.g., Own compensation benchmarking and market analysis, including Radford survey submissions and the maintenance of job architecture, salary structures, and pay bands.
Run the total rewards calendar end to end - merit and bonus planning, mid-year and year-end compensation cycles, and the compensation components of the performance process.
Serve as the subject-matter expert on pay equity, compensation philosophy, and total rewards communications to managers and employees.
HR Operations, Systems & Compliance
Lead the evolution of Encoded's HR operations and service-delivery model, including assessing and, where appropriate, transitioning HR technology, payroll, and benefits delivery to support the company's scale.
Own the HR technology roadmap and serve as system owner for the HR tech stack, with a focus on integration across HRIS, payroll, benefits, and downstream systems.
Own vendor management for key People partnerships - benefits brokers, leave-of-absence providers, HRIS and payroll vendors, and compensation survey providers - including selection, contracting, and performance management.
Oversee the annual operational compliance cycle, including 401(k) plan audit, ACA reporting, Section 125 / FSA non-discrimination testing, and EEO-1 reporting.
In partnership with Finance, build and maintain internal controls and data integrity over HR and payroll data that meet the standards of a maturing, audit-ready organization, and ensure data integrity through audit cycles.
coordinate the external advisors (compensation consultants, counsel) and Finance partners who support these needs.
Bachelor’s degree in Finance, Business, Economics, or HR with 12 + years of progressive total rewards experience, including hands-on compensation design OR a Master’s degree/MBA with 8–10 years of experience featuring strategic program ownership, executive compensation design, and direct board governance exposure.
Demonstrated depth in compensation benchmarking and structure design; fluency with Radford or comparable survey methodology.
Experience owning or leading an HRIS / HR technology implementation or major systems transition.
Strong operational rigor - comfort owning compliance cycles, audits, and the controls and documentation a maturing, audit-ready organization requires.
Proven vendor and project management ability; Encoded considers a variety of factors when determining base compensation, including experience, qualifications, internal equity and geographic location. Actual compensation will be determined based on relevant skills, experience, qualifications, internal equity, and business needs. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives, paid time off, and a benefits package.
Meaningful stock option grants
PTO, sick time and holiday pay
Pre-tax medical and dependent care programs
Professional development opportunities
Team-building events
Fully stocked micro - kitchen
All employment decisions at Encoded are based on business needs, job requirements and individual qualifications, without regard to race, religion or belief, color, national origin, gender, status as a protected veteran, status as an individual with a disability, or any other status protected by the laws or regulations in the location in which we operate. If you need assistance or an accommodation due to a disability, you may call us at View phone number on apply.placed-app.com.
#
- ...Encoded Therapeutics is hiring a Director of Total Rewards & Operations to build and scale compensation, equity, and HR-operations infrastructure across the organization. You will partner with Finance, Legal, and People & Culture leadership to implement robust systems...OperationsFull time
$225k - $280k
...turns siloed and disconnected data into operational intelligence — instantly surfacing... ...journey and are looking for a Sr Director, Total Rewards to help us architect, build and lead... ...knowing when to use which. ~ Located in San Francisco and open to working in office...OperationsFull timeWork at officeLocal area$236k - $295k
...Total Rewards at Ironclad This leader will own the strategy and execution of compensation... ...run cleanly while building the operational foundation beneath them. Build the... ...range for this position based at our San Francisco headquarters. The actual base salary offered...OperationsFull time$315k - $360k
...About the RoleWe’re looking for a Head of Total Rewards to make compensation and benefits a... ...: one where Notion is scaling fast, operating in a highly competitive market, and building... ...or craft. This role is based in San Francisco, CA. We work from our offices on Mondays...OperationsPart timeLocal area$160k - $185k
...information, please visit The Associate Director, G&A Applications will lead the... ...Encoded's manufacturing and supply chain operations. Key Responsibilities G&A... ...onsite time at the Encoded headquarters in South San Francisco expected. Benefits Comprehensive...OperationsFull timeContract workWork experience placementWork at officeRelocation$215k - $260k
...Rigel Pharmaceuticals, a pioneering biopharma company based in South San Francisco, is seeking a dynamic and experienced Director of Forecasting to join the Commercial Analytics team, part of Business Operations. The role offers the opportunity to contribute directly to...OperationsPart timeFlexible hours- ...Peregrine Technologies in San Francisco seeks a Sr Director, Total Rewards to build and lead compensation and benefits programs. This role is critical in... ...in high-growth environments. The position focuses on operational excellence and aligning rewards with company culture...Full time
$204k - $265k
Director, Applied AI page is loaded## Director, Applied AIlocations: South San Franciscotime type: Full timeposted on: Posted 3 Days Agojob... ...efficiency to how Denali operates. At Denali, Applied AI is... ...Denali offers a competitive total rewards package, which includes a 40...Full timeLocal area$204k - $265k
...Denali Therapeutics Inc. in South San Francisco is seeking a Director, Applied AI to develop and lead their AI initiatives. The ideal candidate will bring over 10 years of experience in applied AI with a strong background in compliance and cross-functional collaboration...Full time$172.9k - $242.03k
...are limitless!We’re seeking a Director of Cost Management to support a life sciences client in South San Francisco. This role is ideal for a... ...leadership on cost management operations as well as company, regional... ...salary only, and not the total compensation package. Cumming...OperationsFull timePart timeLocal area$115k - $158k
...Join to apply for the Total Rewards Manager role at MidPen Housing... ...Department: Human Resources - Operations Office: Foster City Office... ...for “Rewards Manager” roles. San Francisco, CA $140,000.00-$180,000.00... ...7,800.00 2 days ago Senior Director, Human Resources Business...OperationsFull timeLive inWork at officeLocal areaWork from home- ...Ironclad is seeking a Total Rewards leader to own strategy and execution across compensation, equity, benefits and related programs. You will shape how Ironclad rewards performance, communicate value, and deliver a scalable employee experience globally. This is a high...Full time
$201.5k
...The PositionGenentech is seeking an exceptional Project Director/Executive Director to lead one of our most transformative capital... ...campus comprising seven state-of-the-art buildings at our South San Francisco headquarters. This is a rare opportunity to direct a monumental...Full timePart timeFor contractorsLocal areaRelocation package$193k - $280k
...life balance. Real rewards for real work: We offer... ...data. The Associate Director of Campaign & Event Technology... ...who enjoys solving operational challenges, improving... ...receive a competitive total rewards package with... .... Pursuant to the San Francisco Fair Chance Ordinance,...OperationsFull timeWork experience placementWork at office$200.7k - $234.15k
## Associate Director, Regulatory AffairsApplyremote type: Hybridlocations: South San Francisco, Californiatime type: Full timeposted on: Posted 2 Days Agojob requisition... ...interactions with health authorities. The position operates in a highly collaborative, fast-paced...Full time$225k - $280k
...Director, Patent Operations A prestigious, innovation-driven global law firm is seeking a Director... ...hybrid and can sit in Boston, DC, NYC, San Francisco, Palo Alto, Santa Monica, or Seattle.... ...filings, and legal support (13 total direct reports). Establish and enforce...OperationsFull timeWork at office$182k - $346k
...Scientific Director / Senior Medical Director, Medical Affairs - Global Oncology Pipeline... ...input into core strategic and operational pipeline medical affairs activities for... ...our Mettawa, IL, Florham Park, NJ, or South San Francisco, CA locations and will follow a hybrid...OperationsFull timeWork at officeLocal area$200k - $250k
...looking for a world‑class Chief Operating Officer (COO) to serve as... ..., Executive Team, Board of Directors, and investors to align global... ...cadence and ensuring total alignment on corporate priorities... ...200,000 to $250,000 base in San Francisco areas. This range is not inclusive...OperationsHourly payFull timeWork at officeLocal areaFlexible hours$135k - $145k
...Chicago, Houston, Washington DC, or the San Francisco Bay Area. We seek a skilled... ...management team. The role of Associate Director is that of a fee-earning consultant... ...Director/Director, Clinical Operations, Autoimmune South San Francisco, CA $180,000.00-$240,...OperationsFull timePart timeFor contractorsWork experience placementSeasonal workWork at officeRemote workFlexible hoursAfternoon shift$283k - $425k
...connection.We’re hiring a Vice President, Total Rewards to be the strategic leader across HR... ...reduce complexity in total rewards operations — rationalizing policies, eliminating... ...Austin, Texas, United States of America; San Francisco, California, United States of...OperationsFull timeTemporary workPart timeRemote work$187k - $220k
...SummaryThe Programs & Projects Director provides project management... ...space planners, and/or CAD operators. Works closely with and... ...geographic location, date of hire, total hours worked, job type,... ...Wakefield”SummaryLocation: San Francisco, California, USAType: Full time...OperationsMinimum wageFull timePart timeLocal areaFlexible hours$205k - $215k
...collaborative work culture and values a rewarding career, then we want to work... ...00.00-$189,000.00 2 weeks ago San Bruno, CA $132,000.00-$189,000.00 2 weeks ago San Francisco, CA $171,000.00-$258,000.00 21... ...185,000.00 1 week ago Product Operations Manager - TikTok Search...OperationsFull time$200.54k - $256k
...August 13, 2026 WHO ARE WE? San Francisco Public Utilities Commission... ..., we have 2,300 employees operating across eight counties... ...Directs the Community Benefits director to ensure success of the SFPUC... ...documents listing occupation and total earnings must be submitted....OperationsPermanent employmentFull timeContract workFor contractorsWork experience placementSelf employmentWork at officeRemote work$215k - $399.4k
...Early Clinical Development (ECD) Clinical Operations partners across Research & Development... ...As a Senior Clinical Operations Asset Director, you will provide strategic leadership... ...for patients.Onsite presence on our South San Francisco campus is expected for at least 3 days...OperationsFull timeLocal areaRelocation package3 days per week$99.31k - $171.61k
...communities, businesses and society. Headquartered in San Mateo, California with more than 4,000 employees... ...engage them in a shared community. Job Summary: As a Total Rewards Manager (Systems & Rewards Operations), you will play a critical role within Rakuten’s Global...OperationsLocal areaWorldwide$331.6k
...seeking a transformational Vice President, Head of Site Services Operations to lead one of our most strategically critical functions.... ...executive role oversees the operational heartbeat of our South San Francisco campus—a 200+ acre complex spanning 5 million square feet...OperationsFull timePart timeWork at officeLocal area$158.25k - $253.2k
...controllership, NPI, accounting and finance operations, M&A and strategic partnership due... ...hubs located in Boston, New York City or San Francisco and follows a hybrid schedule. We rely... ...we have snacks in our officesAxon is a total compensation company, meaning...OperationsPart timeWork experience placementWork at officeRemote work$180k - $225k
...Associate Director - Project Management - Market Lead Turner... ...the business unit into the San Francisco/Bay Area/Northern California... ...business generation and business operations—managing new and existing... ...only and does not include the total compensation package. Turner...OperationsFull timeContract workLocal areaFlexible hours- ...and single-family (including ultra-luxury) assets across the San Francisco Peninsula. We’re lean, driven, and relationship-led—and we’re... ...internal teams to ensure seamless transition from acquisition to operations Play a key role in shaping acquisition strategy long term...OperationsFull timeLocal area
$280k - $350k
...founders and finance teams to accelerate operations, gain real-time visibility, and control... ...role will be based in either our San Francisco, Seattle, or New York office. We are a... ...compensation may be provided as part of a total compensation package.Please be aware, job...OperationsPart timeWork at officeRemote workWork from home
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Head of Operations & Business Management. Be the first to apply!
- operations officer South San Francisco, CA
- business operations director South San Francisco, CA
- senior marketing operations manager South San Francisco, CA
- operational excellence manager South San Francisco, CA
- landscape operations manager South San Francisco, CA
- senior manager clinical operations South San Francisco, CA
- business operations manager South San Francisco, CA
- operations manager hedge fund South San Francisco, CA
- director of operations - healthcare South San Francisco, CA
- dental operations manager South San Francisco, CA
























