Research Pharmacologist

The Pharmacometrics & Systems Pharmacology (PSP) group is seeking a highly motivated quantitative scientist to support the Internal Medicine portfolio through the application of model-informed drug development (MIDD). This role will use pharmacometrics, systems pharmacology, and/or quantitative biology approaches to inform decision-making across drug discovery and clinical development.

The successful candidate will contribute to the development and application of quantitative models to support and accelerate the discovery and development of novel therapeutics. This individual will work in multidisciplinary teams to design studies, interpret data, and guide strategy using mechanistic and/or data-driven modeling approaches.

Candidates from diverse quantitative backgrounds, including pharmacometrics, systems pharmacology, applied mathematics, engineering, statistics, or related disciplines will be considered.

Perform quantitative analyses including (as appropriate):
Model-based meta-analysis
Systems pharmacology / mechanistic modeling
Integrate diverse data sources (preclinical, clinical, literature, biomarkers) for model development and validation
Integrate artificial intelligence into data workflows and analytics

Identify opportunities where modeling can enhance understanding of efficacy, safety, and disease biology

Partner closely with clinical pharmacology, statistics, clinical, translational, and biology teams
Serve as a quantitative expert on multidisciplinary project teams
Scientific Leadership
Contribute to internal scientific strategy and methodological innovation
Prepare high-quality technical reports, presentations, and regulatory documentation
Author or contribute to scientific publications and external presentations
Mentor junior scientists and contribute to best practices in quantitative pharmacology

Pharmacometrics, Pharmacokinetics/Pharmacodynamics, Systems Pharmacology

• Applied Mathematics, Engineering, Physics, Statistics
• Computational Biology, Mathematical Biology, or related quantitative discipline
• Postdoctoral research experience strongly preferred

Experience in metabolic diseases preferred (obesity, type 2 diabetes etc)
Experience applying MIDD approaches in pharmaceutical or biotechnology settings
R, Julia, MATLAB, Python, or equivalent computational platforms
Basic understanding and strong interest in biology and (patho)-physiology
Can translate complex analyses into actionable insights
Thrives in a fast-paced, team-oriented research environment
This role will directly contribute to advancing innovative therapies in Internal Medicine by enabling data-driven, model-informed decisions that improve the efficiency, robustness, and success of drug development programs.

In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.Pfizer compensation structures and benefit packages are aligned based on the location of hire. Relocation assistance may be available based on business needs and/or eligibility.
S. work visa sponsorship (such as TN, O-1, H-1B, etc.) Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States.

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