Principal Investigator, Predictive Toxicology & NAMs
F. Hoffmann-La Roche AG
Genentech, a member of the Roche group, seeks an experienced Principal Scientist/Senior Principal Scientist in Investigative Toxicology to lead strategy, development, and implementation of predictive safety capabilities for Neuroscience and CVRM portfolios. You will drive safety roadmaps for emerging modalities and collaborate with predictive modeling groups to advance NAMs. Role requires Ph.D. with 3–5+ years (or >5 years for Senior Principal) in pharma/biotech safety, plus hands-on leadership #J-18808-Ljbffr F. Hoffmann-La Roche AG
$141.5k - $262.9k
...people we love.Genentech’s Investigative Toxicology group within the Translational... ..., and implementation of predictive and mechanistic safety capabilities... ...Approach Methodologies (NAMs).The Opportunity:The... ...or CRO environments.Senior Principal Scientist: Ph.D. with >5+ years...PrincipalFull timeLocal areaRelocation package$173.1k - $321.5k
...marketed products. This Senior Principal Scientist role is intended... ...assume independent toxicology and safety leadership for multiple... ...knowledge and comprehensive investigations of toxicologic activity, strategic... ...new approach methodologies (NAMs) that strengthen translation...PrincipalFull timeLocal areaImmediate startRelocation package3 days per week$198.9k - $369.3k
...marketed products. This Senior Principal (SE8) role is intended for an experienced toxicologic pathologist who can immediately... ...safety issues and design or lead investigative and mechanistic studies to... ...and new approach methodologies (NAMs) that strengthen translation and...PrincipalFull timeLocal areaImmediate startRelocation package3 days per week- Genentech is seeking an experienced Senior Principal Scientist/Principal Scientist to drive predictive safety capabilities for Neuroscience and CVRM portfolios. You... ...lead strategy, development, and implementation of NAMs, interfacing with cross-functional teams and...Suggested
$173.1k - $321.5k
...marketed products. This Senior Principal Scientist role is intended... ...assume independent toxicology and safety leadership for multiple... ...knowledge and comprehensive investigations of toxicologic activity, strategic... ...new approach methodologies (NAMs) that strengthen translation...PrincipalLocal areaImmediate startRelocation package3 days per week- Genentech in South San Francisco, CA is seeking a Senior Principal Scientist to lead translational safety across multiple development... ...programs, including novel modalities. The role requires integrating toxicology, pathology, pharmacology, translational and clinical data to...Principal
- ...we are scaling our capabilities in whole-human modeling and predictive toxicology. Exceptional modeling talent is a critical lever in... ...extend human health span. About the Role We are seeking a Principal/AD Medicinal Chemist to lead and advance small molecule drug...PrincipalRemote workWork visaFlexible hours
- Genentech is seeking a Senior Principal Scientist in Translational Safety to provide scientific leadership across drug development, from discovery to clinical stages. This role leads independent toxicology and safety programs for multiple development projects, integrating...Principal
- ...company holidays, 401(k) retirement plan with company-match, and an annual incentive program. Position Summary: The Principal Investigator responsibilities are centered around the execution, planning and management of assigned studies. Communicate succinctly with...PrincipalImmediate startFlexible hours
- Genentech, a member of the Roche group, seeks a Principal Scientist to provide scientific leadership across drug development, from discovery to clinical stages. You will synthesize toxicology data, shape safety strategies, and supervise safety studies in collaboration with...Principal
- Heartflow seeks a Principal Clinical Engineer to lead AI performance investigations for SaMD products such as FFRct Analysis and Plaque Analysis. You will oversee escalated technical investigations, collaborating with R&D, Software, Medical, and Regulatory teams to establish...Principal
$177k - $235k
...Position Description:We are seeking an innovative Senior Scientist / Principal Scientist to bridge the gap between traditional antibody... ...of antibodies. You will also ensure that the computational predictions are rigorously validated and that the resulting biological data...Principal- Genentech, located in South San Francisco, seeks a Senior Principal Scientist in Translational Safety to provide scientific leadership... ...clinical development and marketed products. You will integrate toxicology, pathology, pharmacology, translational, and clinical data to...Principal
$194.1k - $305.6k
...accomplished and highly collaborative Senior Principal Scientist to provide scientific... ..., clinical development, bioanalytical, toxicology, chemistry, and program teams to enable... ...programs and manage a team of principal investigators and biologics scientific experts. The candidate...PrincipalContract workFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- Goodfire is seeking an Executive Assistant to support the COO and Principal Investigator, protecting their time to focus on high-impact work. You will own their calendar and inboxes, coordinate travel and meetings, assist with personal tasks, and partner with the Operations...Principal
$147.8k - $274.4k
...OpportunityWe are seeking a highly motivated and collaborative Senior/Principal Machine Learning Scientist to join the Perturbation Biology... ...and scientific venues.In this role, you will:Design and apply predictive machine learning algorithms for lab-in-the-loop perturbation...PrincipalFull timeLocal areaWorldwide$176.2k - $277.3k
Principal Scientist in Peptide Formulation (Discovery Pharm Sci) Position Description The Discovery Pharmaceutical Sciences (DPS) group... ...of preclinical formulations for pharmacology and toxicology studies and ideally for FIH across a variety of administration...PrincipalFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$168.6k - $313k
...a highly motivated and experienced Medicinal Chemist (Senior Principal Scientist) to join our innovative research and development team... ...Familiarity with machine learning and AI-driven platforms for predicting peptide properties, optimizing sequences, and generating novel...PrincipalLocal areaRelocation package$176.2k - $277.3k
...identification and development of new drug candidates. The DPL may also serve on development teams with responsibility for defining the GLP toxicology study strategy and execution, and for the non-clinical safety sections of regulatory documents that support clinical trials and...PrincipalFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$201.3k - $373.8k
...intelligence and machine learning into every stage of antibody discovery—from target assessment and design optimization to developability prediction and portfolio prioritization.But vision without execution is just strategy. We need exceptional scientist-leaders who can take...PrincipalFull timeLocal areaWorldwideShift work$185.2k - $343.9k
...and critical business strategy. We are looking for a visionary Principal Data Scientist to serve as a premier technical consultant to... ...to guide multiple teams in transforming complex data into the predictive and generative engines that power our next generation of healthcare...PrincipalFull timeLocal area$185.2k - $343.9k
...advances in the pharmaceutical industry.The Opportunity: As a Principal Statistical Methodology Data Scientist you will:You serve as a... ...AI/ML in translational research, real-world data integration, predictive biomarkers)Relocations Benefits are not available for this job...PrincipalFull timeLocal areaRelocation packageShift work$141.5k - $262.9k
...OpportunityGenentech’s Department of Antibody Engineering is seeking a visionary Principal Scientist to lead a high-impact laboratory team at the... ...technological capabilities by developing novel methods and predictive assays to de-risk emerging therapeutic formats.Define...PrincipalFull timeWork at officeLocal areaRelocation package- ...this role, you will identify biomarkers that diagnose disease, predict how it progresses, and anticipate patient outcomes in... ...phenotypes to define patient subgroups for precision medicine Investigate disease heterogeneity and genotype-phenotype discordance to uncover...Principal
$196k - $242k
...Francisco, CA. Position Summary We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant... ...machine learning or AI methods to molecular design, property prediction, or compound prioritization Experience with Schrödinger...PrincipalTemporary workLocal areaRemote work1 day per week$164k - $205k
...Principal Scientist, Protein Engineering South San Francisco, California, United States Xaira is an innovative biotech startup... ...studies. Proficiency with protein visualization and structure prediction tools, such as PyMOL and AlphaFold. Strong organizational,...PrincipalFlexible hours- ...Principal Computational Biologist Are you ready to own the strategy behind how Gordian... ...applied ML and perturbation response prediction space given single-cell omics data, spanning... ...prioritization, mechanism-of-action investigation, biomarker discovery, or validation,...PrincipalDay shift
$130k - $161k
...create an inspiring and exciting place to catalyze and enable medical breakthroughs.Position Description:We are seeking a Senior/Principal Associate Scientist to join an interdisciplinary, collaborative team working at the intersection of mammalian stress response pathways...Principal$141.5k - $262.9k
...transforming society.The OpportunityAs a Principal Scientist in Translational Medicine... ...and drive end-to-end pharmacodynamic and predictive biomarker strategies across first-in-human... ..., clinical study reports, and investigator brochures.Partner cross-functionally across...PrincipalFull timeLocal areaRelocation package3 days per week$124.3k - $230.9k
...with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory... ...ADME, PK and translate nonclinical data into human PK and dose predictions.Identify DMPK-related risks, and develop mitigation...Full timeLocal areaRelocation
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