Associate Director, Study Toxicologist

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal's medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Madrigal Pharmaceuticals is seeking an Associate Director, Study Toxicologist to support nonclinical development programs for metabolic dysfunction-associated steatohepatitis (MASH). This role focuses on the execution and scientific oversight of outsourced nonclinical studies supporting regulatory-stage development programs, partnering closely with Nonclinical Development program leads to ensure studies support regulatory submissions and clinical development.

The successful candidate will support studies across toxicology, pharmacokinetics (PK), ADME, and bioanalytical disciplines, working with contract research organizations (CROs) and internal teams to deliver high-quality data aligned with program timelines. The role will support a range of nonclinical studies, including IND-enabling and later-stage safety studies, as programs progress through development.

This role is part of the Nonclinical Development team within Research, supporting Madrigal's growing MASH portfolio and providing opportunities over time to contribute more broadly to nonclinical development strategy.

Key Responsibilities

Study Design & Oversight

• Support the design and execution of nonclinical studies, including toxicology, PK, ADME, and bioanalytical studies.
• Provide scientific oversight of outsourced studies, including protocol input, study monitoring, data review, and final report review.

CRO & Study Management

• Coordinate study placement and management at CROs, including vendor interaction, study startup, and timeline tracking.
• Monitor study conduct at external vendors to ensure quality and alignment with program timelines and objectives.

Data Review & Collaboration

• Review and interpret study data and reports for accuracy, completeness, and scientific rigor.
• Partner closely with Nonclinical Development program leads and cross-functional teams to support integrated development plans and contribute scientific input to nonclinical development strategy as appropriate.
• Maintain clear communication with internal stakeholders and external partners throughout study execution.

Qualifications

Required

• PhD (or equivalent) in Toxicology, Pharmacology, DMPK, or a related scientific discipline.
• Relevant pharmaceutical or biotechnology industry experience supporting nonclinical development programs and 10+ years of relevant experience.
• Experience managing outsourced nonclinical studies with CROs, including protocol and report review.
• Strong attention to detail and ability to manage multiple studies simultaneously.
• Excellent written and verbal communication skills.

Preferred

• Experience with small molecule and/or siRNA programs.
• Experience supporting late-stage nonclinical studies, including reproductive and developmental toxicology (DART) and carcinogenicity studies.

Madrigal's Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate's qualifications, skills, education, experience, business needs and market demands. As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $178,000 - $218,000 per year. We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws.

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [click to reveal email address] View email address on us.fitly.work .

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law.

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established.

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site.

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals' Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal's name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [click to reveal email address] View email address on us.fitly.work .