Principal Scientist, Mass Spectrometry

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer. General Description At BeOne Institute, we extend BeOne's execution strength with a dedicated innovation engine, bringing agility and scientific depth to transform uncertainty into actionable and high-impact therapeutic opportunities. We operate according to three core principles: Bold Exploration: we pursue novel and high-potential ideas through rapid, iterative innovation cycles. Strategic Alignment: we prioritize disease areas that align closely with BeOne's R&D priorities and long-term vision. Pipeline Impact: we translate insights into tangible assets and advance emerging platforms into impactful programs. As a Principal Scientist at BeOne Institute, you will play a key role in conceptualizing, enabling, and driving cutting-edge research at our San Carlos, CA site. You will apply advanced mass spectrometry technologies to uncover novel biological insights, enable emerging therapeutic modalities, and develop innovative screening and characterization approaches that expand the frontiers of drug discovery. Working at the interface of biology, chemistry, and technology development, you will help define new ways to interrogate complex biological systems and generate actionable insights that can be translated into transformative medicines. This is a rare opportunity to pursue bold ideas and translate them into real medicines! Essential Functions Of The Job Contribute creatively to the scientific direction of the Institute by ideating, challenging, and advancing bold, high-impact research opportunities. Design and execute innovative research programs that leverage mass spectrometry to address important biological questions, enable emerging therapeutic modalities, and create new capabilities for drug discovery. Develop, optimize, and apply mass spectrometry-based screening, proteomics, and analytical workflows to support compound discovery, target identification, target engagement, mechanism-of-action studies, and biological pathway interrogation. Drive the evaluation and implementation of emerging mass spectrometry technologies, workflows, and applications to expand scientific and technical capabilities. Lead the scientific operation and continuous advancement of mass spectrometry platforms, ensuring robust analytical performance and high-quality data generation. Analyze, interpret, and communicate complex mass spectrometry datasets, translating results into actionable biological and drug discovery insights. Partner closely with scientists across biology, chemistry, and other disciplines to develop fit-for-purpose analytical strategies and advance multidisciplinary research programs. Maintain high-quality experimental records and documentation, and stay current with advances in mass spectrometry, analytical technologies, and related scientific fields. Supervisory Responsibilities May be a contact for external CRO partners when needed May provide matrix or line-function leadership for project teams when needed Computer Skills Proficiency with mass spectrometry data acquisition, processing, and analysis software. Strong computational and data analysis skills, including experience analyzing complex quantitative mass spectrometry datasets. Experience with software and tools for MS-based screening and assay development. Required Qualifications Ph.D., M.S., or B.S. degree in Analytical Chemistry, Biochemistry, Biology, Chemistry, Pharmaceutical Sciences, or a related scientific discipline, and 6+ years (Ph.D.), 8+ years (M.S.), or 10+ years (B.S.) of relevant industry, academic, or postdoctoral experience. Ph.D. highly preferred. Deep expertise in mass spectrometry, with demonstrated hands‑on experience operating, maintaining, troubleshooting, and optimizing LC-MS instrumentation. Strong experience developing and implementing mass spectrometry-based screening and proteomics workflows. Demonstrated ability to apply mass spectrometry to address complex biological questions and generate mechanistic insights Experience with quantitative proteomics and/or other MS-based approaches for protein identification, characterization, interaction analysis, or pathway interrogation. Experience developing and optimizing sample preparation, chromatography, and MS methods to enable sensitive, robust, and reproducible biological assays. Strong data analysis and interpretation skills, with the ability to extract meaningful biological insights from complex mass spectrometry datasets Demonstrated ability to independently troubleshoot analytical challenges and develop creative solutions to enable new applications and research capabilities Ability to partner effectively with scientists across biology, chemistry, and other disciplines to translate biological questions into fit-for-purpose mass spectrometry approaches Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences Be able to work on-site in San Carlos, CA Preferred Qualifications Experience with Orbitrap systems (Astral a plus) and Agilent Q-TOFs strongly preferred. Knowledge of cancer pathways. Experience with ASMS and APMS workflows (in a drug discovery setting a plus). Travel None Global Competencies Fosters Teamwork Provides and Solicits Honest and Actionable Feedback Self-Awareness Acts Inclusively Demonstrates Initiative Entrepreneurial Mindset Continuous Learning Embraces Change Results-Oriented Analytical Thinking/Data Analysis Financial Excellence Communicates with Clarity Salary Range: $165,300.00 - $206,600.00 annually BeOne is committed to fair and equitable compensation practices. Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Packages may vary by location due to differences in the cost of labor. The recruiter can share more about the specific salary range for a preferred location during the hiring process. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. All Company employees have the opportunity to own shares of BeOne Medicines Ltd. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness. We are proud to be an equal opportunity employer. BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. All employment is decided on the basis of qualifications, merit, and business need. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact View email address on click.appcast.io. #J-18808-Ljbffr