Staff Accountant

Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.


Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit

Position Summary

The Staff Accountant will play a key role in the accounting and financial activities for Prime Medicine. In this crucial role, the Staff Accountant will have exposure to a wide range of business and operational initiatives, accounting and financial reporting activities and ad hoc projects.

This role is focused on monthly and quarterly close financial procedures and supports the Procure-to-Pay functions. The candidate will join an evolving finance and accounting team recognized as valued business partners. This position offers exposure to many levels of the organization, providing outstanding opportunities to influence the direction of the business and to grow your career.

Position will report directly to Associate Director of Procurement.
Key Responsibilities

• Execute month-end, quarter-end, and year-end close activities in a timely and accurate manner, including preparation and posting of journal entries, account reconciliations, roll forwards and variance analyses
• Provide internal customer service support for the Procure-to-Pay (P2P) processes and day-to-day activities, ensuring users are properly trained and transactions are recorded accurately
• Maintain Vendor Master File and act as the primary contact for vendor inquiries regarding payment status and statement reconciliation
• Lead efforts around accounts payable efficiencies, including driving automation and other process enhancements
• Manage weekly cash disbursement processes, coordinate payment approvals and payment timing
• Oversee and manage Concur for employee expense reports from review to reimbursement, ensuring compliance with company policies
• Manage fixed assets and depreciation ensuring compliance with accounting standards and company policies

• Support external and internal audits by preparing schedules, reconciliations, and documentation
• Ensure business transactions continue to be in accordance with generally accepted accounting principles, policies, and SOX controls

• Assist with special projects and ad-hoc analysis across accounting functions as assigned

Education & Experience

• Bachelor's degree in finance or accounting (preferred), with 2-3 years of progressive accounting experience with at least 2 years in public accounting or a high-growth tech/life sciences company

• Strong understanding of U.S. GAAP and willingness to deepen technical accounting knowledge
• Proficiency in MS Office (especially Excel) and experience with accounting/ERP software

Required Skills & Competencies

• Demonstrated analytical skills to solve complex problems and address a variety of variables in situations with limited standardization
• Strong organizational skills to effectively balance priorities, handle workload, and complete projects on time
• Highly organized and diligent, with time management abilities
• Strong interpersonal skills for effectively communicating with internal & external stakeholders of all levels.
• Ability to work independently across multiple financial systems and troubleshoot/resolve issues as needed.
• Self-motivated and capable of working independently
• Hybrid work position with some in-person attendance required (Cambridge, MA)

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).

Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits-including medical, dental, vision, life insurance, a 401(k) match, and equity programs-along with generous paid time off, wellness days, and company-wide recharge breaks.

Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.

U.S. Pay Range

$77,000-$95,000 USD

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.