Global Development Product Lead (Sr Director)

Responsibilities Lead multiple (~1-3) cross‑functional oncology product teams from pre‑clinical candidate nomination (CAN) through Phase 1–2 clinical development and proof of concept (POC); may transition the molecule to late‑stage Oncology Development for post‑POC (typically Phase 3) development. Integrate an end‑to‑end cross‑functional molecule strategy and risk mitigation plan with functional experts; ensure delivery of data‑driven milestones through risk identification and mitigation. Support clinical trials and development strategy for early development assets and lead development programs across multiple Pfizer Oncology functions; represent programs with the external clinical community. Develop clinical development plans from first‑in‑human to POC, including assessment of appropriate combinations and evaluation of predictive and pharmacodynamics biomarker plans. Ensure clinical plan components and clinical expertise are provided to project teams, including medical monitoring of clinical trials. Lead strategic development for early development assets; develop and execute an integrated product plan addressing near‑term technical uncertainties and aligning with pivotal development and commercialization. Ensure timely execution and delivery of product milestones within budget. Communicate with executive management and governance committees; provide recommendations and clear product presentations/communications. Collaborate on co‑development programs to deliver shared global product strategy (as applicable). Set objectives, prioritize tasks, and ensure adherence to plan and strategy. Proactively identify and resolve issues, manage risk, and develop contingency plans. Oversee early development assets within specific indications/group of indications (typically at least two clinical programs) and consult on multiple research projects. Work across multifunctional teams (Product, Global Development, and Study teams). Oversee clinical protocols and amendments, investigator brochures, clinical study reports, statistical analysis plans, and regulatory documents. Provide leadership to early‑stage clinical scientists in matrix teams; meet regularly with oncology group leaders/surrogates across functions. Implement PK‑guided dose escalation, early combination strategies, and emerging innovations on first‑in‑human Oncology R&D trials. Oversee evaluation of safety, pharmacology, and efficacy data from ongoing and completed studies. Oversee manuscripts, abstracts, and presentations for scientific meetings and advisory boards. Conduct literature reviews and prepare summaries to support clinical development programs. Serve as medical resource for design and interpretation of clinical and preclinical programs for existing and new candidates. Coordinate regular interactions (at least quarterly and as needed) with clinical trials networks and KOL advisory boards to consider and implement feedback. Drive innovations in early clinical development using translational oncology and precision medicine approaches. Translate early preclinical discovery research into therapeutic candidates with cross‑functional leaders. Coordinate with business development on strategic external collaborations and new research projects/programs. Qualifications / Skills MD or MD‑PhD with 5+ years of industry experience (required). Oncology drug development experience; track record in oncology clinical research including early phase drug development (preferred). Clinical oncology experience; board certification in oncology (preferred). Significant industry leadership experience in clinical, translational, or basic research in biomedical sciences or related drug development disciplines. Understanding of related disciplines (e.g., biostatistics, regulatory, pre‑clinical pharmacology, pharmaceutical sciences). Demonstrated scientific productivity (publications, abstracts, etc.). Proven scientific writing and communication skills. Proven leadership ability to defend the clinical plan at governance meetings (essential). Ability to adapt to fast‑paced, changing environments. Demonstrated history of effective leadership in cross‑functional/matrixed teams; managing direct reports when applicable; seeking and maintaining alignment with cross‑functional leaders. Passion for helping patients with cancer and for the science of oncology. Proactive, strategic thinker with strong data‑driven decision‑making. Ability to focus and motivate teams in matrix organizations with multiple stakeholders. Strong verbal, written, and presentation communication skills. Staff management and mentoring experience. Highly collaborative with strong relationship‑building skills with internal/external partners and investigators/medical professionals. Strong leadership presence. Team player; works well as both leader and contributor. Global perspective and ability to work across cultures, backgrounds, and geographies. #J-18808-Ljbffr