Principal Scientist - Quantitative Translational Scientist

Role Summary Regeneron’s Precision Medicine Quantitative Biomarker team (PMQBS) is seeking a Principal Scientist with a blend of deep biomarker and translational-science expertise coupled with advanced computational and analytical skills. The role primarily focuses on the Oncology portfolio and involves exploratory analyses and visualization of omics, EHR, wearable sensor, imaging, and other biomarker data. You will help develop tools and dashboards for querying, visualizing, and cleaning data and collaborate with internal and external groups to ensure data integrity, best practices for analytics and data visualization, and offer strategic insights that drive Precision Medicine objectives. Typical Day Set and refine quantitative biomarker strategies across multiple programs, aligning with Precision Medicine Strategy Leads and senior stakeholders. Translate program objectives into testable hypotheses, analytical roadmaps, and decision criteria that inform clinical development and asset strategy. Architect exploratory analyses of multi-modal datasets (genomic, transcriptomic, proteomic, metabolomic, clinical, and other biomarkers) to generate actionable insights. Define and review statistical frameworks, including hypothesis testing, modeling approaches, and power/sample-size analyses, ensuring appropriate interpretation. Oversee the correct application of statistical models on integrated datasets and drive clear, decision-orientated interpretation for translational and clinical teams. Contribute to the vision for scalable, reproducible pipelines and automated workflows that support enterprise-wide biomarker discovery and clinical development. Direct the design and enhancement of computational workflows for novel biomarkers; evaluate, integrate, or build tools as needed. Provide guidance on data cleaning, integration, and visualization standards to enable robust, interpretable analyses. Qualifications Proficient in statistical modeling, regression, machine learning, and related data integration or blending techniques. Experienced in implementing scalable workflows on cloud platforms (AWS, GCP, or Azure). Experienced in Linux or cloud environments, shell scripting, and notebook-based workflows. Knowledgeable of structured data and data mapping for systems integration, data provisioning, and consumption. Experience with version control and AI coding assistants such as Claude Code is strongly preferred. PhD with a minimum of 2 years of relevant industry experience or a Master’s with a minimum of 5 years of relevant industry experience in Computer Science, Computational Biology, Systems Biology, Quantitative Biology, Bioinformatics, Data Analytics, or Biostatistics. Working understanding of clinical trials is a strong plus. Benefits and Compensation Benefits vary by location and may include health and wellness programs (medical, dental, vision, life, and disability insurance), fitness centers, 401(k) company match, family support benefits, equity awards, annual bonuses, paid time off, and paid leaves (e.g., military and parental leave). The salary range for U.S. positions is $128,600.00 – $210,000.00. Equal Employment Opportunity Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. The Company will also provide reasonable accommodation to the known disabilities or chronic illnesses of a qualified applicant for employment, unless the accommodation would impose undue hardship on the operation of the Company’s business. #J-18808-Ljbffr Regeneron Pharmaceuticals, Inc (USA)