Postdoctoral Fellow-MSH-30025-251

RESEARCH FOCUS

Our research aims to uncover the molecular mechanisms that govern cancer cell behavior by focusing on:

• Functional heterogeneity within tumors
• Phenotypic plasticity during tumor evolution and therapy response
• Cellular competence in tumor initiation, adaptation, and drug resistance

Rather than simply cataloging cellular states, we seek to identify the mechanisms that establish, maintain, and regulate them. We combine genetic barcoding-based lineage tracing, functional genomics, organoid and mouse models, CRISPR perturbations, and single-cell multiomics to track cancer evolution at clonal resolution and uncover causal regulators of cancer cell identity and behavior. The laboratory includes both experimental and computational researchers, fostering a collaborative and interdisciplinary approach to studying cancer evolution and cell-state dynamics. Current Research Areas

• Cellular competence and tumor evolution
• Phenotypic plasticity, memory, and adaptation
• Developmental programs and cancer cell states

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