Senior Researcher

SiRNA in-vitro screening

Mammalian Cell culture, RT-qPCR, and cell-based assays (ELISA/Western Blot/CRISPR) is a must

Primary and immortalized cells (mammalian and human) are required

Some In-vivo experience/mouse handling/animal dosing experience is required

Exp with - Hepatocytes/Adipocytes is highly preferred- Deciding factor

PhD is overqualified

Masters degree is required with 4yrs. experience. Can consider Bachelors for 6+yrs. experience with all skills

Exp with 3d culture and organoids is plus.

Purpose:

To provide technical laboratory research effort in support of multiple projects focused on expedited evaluation and the clinical translation of therapies.

Essential Functions:

• siRNA drug candidate screening, hit identification, and lead optimization
• Cellular and molecular biology methodologies, e.g., mammalian cell culture; in vitro screening; cell-based assays; RNA extraction and RT-qPCR
• Analyze data and present the results in group meetings
• Maintain clear experimental records in laboratory notebooks; write SOPs and other technical reports as needed
• Work closely with research team members to quickly and effectively address critical questions related to the efficacy of our drugs
• Review literature and provide insights to research directions, while predominantly making hands-on contributions to the research

Qualifications:

• Masters in Cell and Molecular Biology or Pharmaceutical Sciences
• 4+ years of relevant drug discovery laboratory experience in industrial or academic environment is preferred
• Experience in cellular and molecular biology is essential (e.g., mammalian cell culture, cell-based assays, quantitative real-time PCR)
• Experience with primary human adipocytes and hepatocytes culture is preferred
• Experience with advanced in vitro model systems including organoids and other 3D culture systems is highly preferred
• Experience with RNAi and in vitro screening is preferred
• Candidate must have strong oral and written communication skills, strong work ethics and demonstrated to be an effective contributor to group projects in a team-oriented environment
• The ability to perform and interpret experiments reliably, and to advance projects aggressively towards defined goals is expected