ADME Project Leadership for Genetic Medicines

Job ID: R-89989Company: LillyLocation: Boston, Massachusetts, United States of AmericaJob Type: Full TimeCategory: Research & DevelopmentPosted Date: 2025-07-23At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.Our diverse ADME team is seeking a dedicated scientist with an interest in the discovery and clinical development of genetic medicines, including siRNAs, ASOs, mRNAs, gene editing, and gene therapy. We are committed to advancing scientific boundaries to develop transformative therapeutics that address the underlying causes of diseases across a wide range of therapeutic areas. Applicants with strong problem-solving abilities and innovative thinking are encouraged to apply to join our team at the expanding Boston campus.Lilly’s agile ADME team collaborates closely with biologists, chemists, engineers, and various other R&D functions to deliver novel genetic medicines to patients. Team members support each other through shared learning and collective responsibility for all stages of the discovery and development process for next-generation genetic therapies. We strive to foster professional growth while advancing science to provide safe and effective new treatments to patients. Prospective candidates who are motivated, collaborative scientists interested in spearheading innovation in genetic medicine therapies are invited to connect with us and contribute to improving patient outcomes globally.A high-quality candidate will demonstrate the following:High learning agility and a keen ability to articulate and efficiently test ADME and DMPK hypotheses for complex novel moleculesStrong working knowledge in fundamental pharmaceutics, pharmacokinetics/pharmacodynamics, and ADME principles - especially as they relate to novel genetic medicine therapeutic modalitiesUnderstanding of pharmaceutical regulatory guidance and expectationsAgile interrogation of diverse data (e.g., in silico, in vitro, in vivo) to interpret complex data sets and to derive mechanistic understanding of drug action and ADME/DMPK characteristicsLilly seeks a skilled ADME / DMPK scientist who will:Lead and innovate in a multidisciplinary team environment with primary responsibility for ADME studies to support preclinical and clinical development of the Lilly genetic medicines portfolioDesign, implement, and interpret hypothesis-driven studies to inform key ADME, PK/PD, and toxicokinetic (TK) questionsIntegrate ADME, PK and PK/PD endpoints with discovery chemistry and biology data to guide preclinical drug design, optimization, and delivery strategies.Engage, innovate, and collaborate with cross-functional colleagues and interdisciplinary teamsLead the preparation of ADME portions of regulatory communications and documents to support clinical development, new drug applications, and line extensions and interact with global regulatory authoritiesMentor and support junior scientists and build relationships through coaching and mentorship with fellow scientists at all levelsPossess excellent written and verbal technical communication and the ability to constructively lead, guide and influence teamsBasic Requirements:Ph.D. in Biochemistry/Biology/Pharmacokinetics/Bioengineering/Pharmacology or a related scientific fieldGreater than five years of experience as a scientist in a pharmaceutical and/or biotechnology company in a role related to ADME or PK/PDAdditional Skills/Preferences:Knowledge of DMPK and/or bioanalytical considerations for gene editing therapeuticsExperience with PK/PD modeling and simulationExperience with targeted delivery and biodistribution of oligonucleotides and/or gene therapiesUnderstanding of and experience with PCR, immunoassay, and/or LC/MS bioanalytical methodologyAdditional Information:This is a full-time position located in Boston, MA.Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form () for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women’s Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is$184,500 - $321,200Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.#WeAreLillySkillsadme principlespharmacokineticspharmacodynamicsgene therapysirnasasosmrnasgene editingdmpkbioanalytical methodologypk/pd modelingdata interpretationtechnical communicationteam collaborationmentoringproblem-solvinginnovative thinking