Senior Director, Global Value & Access Strategy - Povetacicept Lead

Job Description Background and Job Description: Vertex Pharmaceuticals operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF), Casgevy, a gene therapy for sickle cell disease and beta-thalassemia and Journavx, a novel new treatment for moderate to severe acute pain. Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in kidney diseases, Type 1 diabetes, among others. Povetacicept is a highly potent and effective dual antagonist of BAFF and APRIL pathways with potential best-in-class efficacy in patients with IgA nephropathy (IgAN). IgAN is a serious, progressive, autoimmune disease of the kidney that can lead to end-stage-renal disease. IgAN is the most common cause of primary (idiopathic) glomerulonephritis worldwide. Due to its mechanism of action as a dual BAFF/APRIL antagonist, povetacicept holds the potential to benefit patients for multiple additional serious diseases including other autoimmune kidney diseases and autoimmune cytopenias such as primary membranous nephropathy (pMN) and generalized myasthenia gravis (gMG). Vertex is seeking a Senior Director of Global Value & Access Strategy (GVAS) for povetacicept, reporting to the ED Kidney Lead, to join our dynamic team in Boston, MA. The Senior Director will be the Market Access Asset Lead for povetacicept in IgA nephropathy (IgAN) and future indications, including pMN and gMG. In this capacity, the individual will be responsible for evolving the global price and access strategy (P&MA) for IgAN and driving development of the LCM/portfolio P&MA strategy, as well as leading the cross-functional, cross-regional Value & Access Strategy Working Team. The successful candidate will serve as the voice of the payer internally to ensure that P&MA implications are considered in key program decisions.This role will also be accountable for leadership of cross-portfolio capability building and thought leadership projects that advance knowledge of and readiness for the rapidly evolving global payer environment. The successful candidate will be strategic, demonstrate strong cross-functional leadership, thrive in complexity, and have a problem-solving mindset backed by strong analytical skills. The candidate must share our passion for science-based brands that can dramatically improve patients’ lives. As a senior member on the GVAS team, the successful candidate must be able to role model Vertex’s ethics & culture and be committed to developing the next generation of leaders. They will also manage two direct reports. Key Responsibilities: Responsible for evolving the overall development and communication of the Global pricing & market access strategy for povetacicept within cross functional, cross-regional commercialization processes. Ensure global market access launch readiness for IgAN lead indication Ensure delivery of differentiated branded, branded payer value communications and supportive training Lead the evolution of the global price and market access strategy in IgAN Partner cross-functionally and cross-regionally to ensure robust integrated evidence plans to support global market access and reimbursement at launch and over time Responsible for development of the P&MA strategies for future indications/portfolio Partner within commercial to develop overall LCM strategy, including indication sequencing Ensure P&MA strategies are supported by payer insights and robust global payer plans Identify, prioritize and champion evidence required for access enabling trials and value optimization Provide leadership within the Global Commercial Model and shape commercial strategy; contribute directly to Commercialization Strategy Team and the Disease Strategy Team to ensure the payer position is consistently represented Lead cross-portfolio capability building and thought leadership projects that advance knowledge of and readiness for the rapidly evolving Global payer environment Effectively lead cross-functionally and cross-Regionally, particularly across Market Access teams, HEOR, Real World Evidence, Government Affairs and Public Policy and to ensure alignment around and delivery against access goals Provide direct, “hands-on” development of strategic and tactical deliverables as required Manage 2 direct reports Experience & Qualifications: Bachelor’s degree required, ideally in life sciences, post graduate preferred 12+ years of direct biotechnology / pharmaceutical industry experience; 5+ years of supervisory/management experience preferred Deep working knowledge of both US and ex-US healthcare systems required; experience in a comparable global and/or specialty disease area role, especially involving product launches in highly competitive markets with potential for expansion into multiple indications, considered a plus Demonstrated ability to think strategically and make sound pricing and market access recommendations Strong practical, quantitative and analytical skills combined with a sound understanding of how to successfully apply pricing & reimbursement / HEOR principles to support Vertex Exhibits outstanding written and oral communication skills, including the ability to effectively write and deliver presentations to professionals at all levels within Vertex Demonstrated ability to manage initiatives that require cross-functional collaboration and relationships at all levels of the organization and across geographies General experience in commercialization and drug development Recognized as a team player with excellent interpersonal skills who is flexible and reliable Displays sound ethics and a fit for Vertex’s core values and culture Pay Range: $240,000 - $360,000 Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law. At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more. Flex Designation: Hybrid-Eligible Or On-Site Eligible Flex Eligibility Status: In this Hybrid-Eligible role, you can choose to be designated as:

1. Hybrid : work remotely up to two days per week; or select
2. On-Site : work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at View email address on click.appcast.io #J-18808-Ljbffr Vertex Inc.