Associate Director, Computational Chemistry

Revolution Medicines seeks an Associate Director of Computational Chemistry to lead structure-based drug design efforts supporting oncology drug discovery programs. The role involves guiding computational strategy, managing multidisciplinary teams, and advancing hit-finding and lead optimization efforts for RAS-targeted therapeutics.

Responsibilities

• Lead computational chemistry strategies for drug discovery programs from hit identification through lead optimization
• Coordinate computational contributions to translational research, setting priorities and milestones
• Partner across medicinal chemistry, structural biology, and screening to resolve complex design challenges
• Evaluate and advance computational methods including molecular dynamics and free energy approaches
• Mentor junior scientists and establish standards for reproducibility and knowledge sharing

Requirements

• Ph.D. in computational chemistry or related field
• 10+ years post-doctoral experience in computational chemistry
• Expertise in structure-based drug design and molecular modeling
• Experience with molecular dynamics, free energy calculations, and enhanced sampling
• Track record leading cross-functional discovery teams
• Knowledge of AI/ML applications in drug discovery