Senior Scientist I, Computational Protein Design
Generate Biomedicines
Generate Biomedicines seeks a Senior Scientist to develop computational methods and lead applied research in protein design and engineering. The role combines technology development with platform research, bridging computational innovation and experimental validation to advance protein therapeutics.
Responsibilities
- Identify capability gaps and lead technology development projects from hypothesis to validated platform
- Develop computational methods for protein design, optimization, and interaction modeling
- Create scoring systems and benchmarks to evaluate protein sequences, structures, and functions
- Partner with experimental scientists to design molecular libraries and conduct iterative studies
- Build agentic systems and workflows connecting models, data, and experimental tools
Requirements
- Experience developing computational methods for protein design or molecular engineering
- Proficiency with generative and predictive modeling approaches
- Strong background in structural biology or biophysics
- Demonstrated ability to design and execute iterative design-build-test studies
- Experience translating research findings into validated, reusable capabilities
- Collaborative experience with experimental and structural scientists
$130.8k - $209.4k
The RoleModerna is seeking a Senior Scientist to support the AI-enabled design of de novo antibodies, binder and antigen... ...role for an experienced protein designer who can build and operationalize... ...report to the Senior Director, Computational Design and In Vitro Selection,...SeniorPermanent employmentFull timeWork from home$82k - $92k
...Description Our company's Discovery Biologics is seeking a talented postdoctoral scientist motivated to push the boundaries of computational protein engineering and next-generation biotherapeutics design. In this role, you will develop and apply state-of-the-art artificial...SuggestedFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- Moderna is seeking a Senior Scientist to lead AI-enabled design of de novo antibodies, binder and antigen modalities across discovery programs. This is a hands-on, highly technical role for an experienced protein designer who can operationalize agentic AI design frameworks...Senior
- Generate:Biomedicines seeks a machine learning scientist to lead the development of lab‑in‑the‑loop design systems for therapeutic proteins. You will focus on probabilistic ML, sequential decision making, and experimental design, partnering with protein designers and wet...SeniorWork at office
- Tessera Therapeutics in Somerville, MA, is seeking a highly motivated Computational Biologist to join the Computational Biology team. You will design and run experiments with biologists, develop tools for processing molecular data, and present findings to an interdisciplinary...SeniorLocal area2 days per week3 days per week
- Research Leader / Senior Scientist (Computational Drug Design), Cambridge, MA Cambridge, MA Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The...SeniorContract workWork at office3 days per week
$142.5k - $256.5k
...This role will lead the design, execution, and... ...and rapid maturation of computationally designed candidates.The... ...closely with computational protein design teams to ensure... ...is intended for a scientist ready to own and evolve... ...with and report to the Senior Director,...Permanent employmentFull timeWork at officeWork from home$125k - $165k
...Biomedicines is looking for a talented Senior Scientist I to join the Protein Analytics & Biophysics team within... ...conditions, and project questions.Design experiments, establish appropriate... ...Protein Sciences, Technology, computational and machine-learning teams, and other...SeniorShift work$135k - $150k
....About the role. We are seeking a Senior Scientist to drive key protein engineering workstreams within campaigns... .... You will play a key role in designing and executing protein engineering... ...work closely with project leads, computational scientists, and experimental teams...Senior$126k - $181.5k
...recruiting a team of top-tier scientists to build this powerful... ...highly collaborative Senior Scientist to join FL12... ...of experimental and computational scientists building a... ...candidate will design, construct, and functionally... ...interrogate large protein variant libraries — linking...Senior- ...Generate Biomedicines seeks a Computational Protein Design Scientist to develop therapeutic proteins using computational design, machine learning, and experimental biology. The role bridges computational platform teams with therapeutic programs, translating design hypotheses...
$180k - $258.5k
...pioneering the emerging field of Protein Editing. At Expedition... ...(ML) to enable generative design. Expedition Medicines is backed... ...motivated and innovative (Senior) Scientist, Machine Learning to join... ..., quantum chemistry, and computational drug discovery to drive impact...Senior$115.99k - $172.67k
...Bioinformatics Scientist Are you ready to harness multi-omics, comparative... ...insights that shape antigen design, patient stratification, and... ...at the intersection of computation and experiment—designing... ...of structural biology tools, protein modeling, or antigen/antibody...SeniorTemporary work$82k - $92k
...Postdoctoral scientist position at Merck's Discovery Biologics in Cambridge, MA, focused on developing AI/ML and physics-based computational tools for protein design and structure prediction. The role emphasizes ensemble-aware design methodologies to advance biotherapeutics...- ...Isomorphic Labs seeks a Research Leader or Senior Scientist in computational drug design to provide scientific expertise and strategic direction for drug discovery projects. The role combines computational chemistry leadership with AI platform enhancement, working at the...Senior
- ...Computational BiologistA Few Words About Us Integrated Resources, Inc... ...Epigenetics Group is seeking a scientist who is passionate about... ...and clinical scientists to design experiments that probe multiple... ...transcriptomes; DNA, histone, and protein methylation; chromatin...Flexible hours
$168k - $252k
...Working at the intersection of Computational Drug Design, project teams, Data &... ...scientifically rigorous AI co-scientists that enhance compound... ...and agentic capabilities to protein therapeutics and other emerging... ..., data scientists, and senior leaders across a matrixed organization...SeniorFull timeSummer workRemote workFlexible hours2 days per week3 days per week- ...Senior Scientist, High-Throughput Protein Binder Screening Location: Watertown, MA Employment Type: Full... ...technologies, automation, and computational modeling to generate biological data... ...validation datasets that enable the design of better therapeutic proteins....SeniorFull time
$176k - $304k
...Life Sciences AI, the AI for Protein Engineering team builds... ...systems that take a biologic from design specification to wet-lab... ...re hiring a machine learning scientist to design molecules on real... ...throughput, and inference cost of computational design workflows. Work with...Full timeWork at officeLocal areaFlexible hours- Merck's Discovery Biologics in Cambridge, MA seeks a postdoctoral scientist to push boundaries in computational protein engineering and next-generation biotherapeutics design using state-of-the-art AI/ML and physics-based modeling. You will explore ensemble-aware design...
$132k - $259k
...pioneering a new frontier at the intersection of neuroscience and computation. We are developing next-generation technologies to transform... ..., and passion goes a long way.The Role:FL119 is seeking a (Senior) Scientist, Computational Neuroscience to join our team. Leveling is...SeniorFull timeFlexible hours$141k - $171k
...environments.Experience with AWS/cloud computing, version control,... ..., multi-disciplinary team to design, analyze, and interpret multi... ...Collaborating closely with experimental scientists to ensure that data is... ...broad audiences, including senior leadership, to drive decision...SeniorLocal area2 days per week3 days per week$101.4k - $154.7k
POSITION SUMMARY:The Senior Field Application Scientist, Protein XI (FAS) will play a critical role in supporting... ...• Guide customers on experimental design, sample preparation, assay... ...communicating results to bench + computational stakeholders.• Ability and willingness...SeniorFull timeTemporary workFlexible hours- Moderna Therapeutics is seeking a Principal Scientist to lead integrated antibody discovery... .... You will oversee immunization design, B cell discovery, display‑based engineering... ...with antigen design, structural and computational biology groups to advance programs. The...Senior
$118k - $138k
...biotechnology company pioneering AI-guided protein design and massively multiplexed in vivo... ...else can match. The datasets power our computational models, which leads to better drug... ...engineers, biologists, and computational scientists works across this full stack to pursue...$106k - $123k
...company pioneering AI-guided protein design and massively multiplexed... ...match. The datasets power our computational models, which leads to... ...biologists, and computational scientists works across this full... ...pharmacology programs. This is a senior, hands-on role at the...SeniorContract work- Zealand Pharma U.S., Inc. in Cambridge, MA is seeking a Scientist or Senior Scientist in Protein Purification and Analysis to deliver high-purity samples for discovery programs and structural biology studies, working hands-on with diverse purification technologies. You...Senior
- Zealand Pharma in Cambridge, MA is seeking a Scientist or Senior Scientist in Protein Purification and Analysis to deliver high-purity protein and bioconjugate samples for downstream mass spectrometry and structural biology studies. You will purify recombinant proteins...Senior
$126k - $181.5k
...recruiting a team of top-tier scientists to help build it. This... ...a highly innovative Senior Scientist with deep... ...record in membrane protein engineering and surface... ...candidate will design, build, troubleshoot,... ...Experience Proficiency with computational protein design tools (...Senior$125k - $170k
## Scientist/Sr. Scientist, Protein PurificationApplylocations: Cambridge, MA, UStime type: Full timeposted... ...new position** As a Scientist or Senior Scientist in Protein Purification and... ...multidisciplinary discovery hub integrating computational research, chemistry, and biology,...Senior
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Scientist I, Computational Protein Design. Be the first to apply!
- research scientist machine learning deep learning Somerville, MA
- image scientist Somerville, MA
- health scientist Somerville, MA
- regulatory scientist Somerville, MA
- scientist biology Somerville, MA
- drug safety scientist Somerville, MA
- principal applied scientist Somerville, MA
- machine learning research scientist Somerville, MA
- cell culture scientist Somerville, MA
- research scientist Somerville, MA



