Senior Manager, Commercial Data Governance & Management

About Stoke:

Stoke Therapeutics (Nasdaq: STOK), is a biotechnology company dedicated to restoring protein expression by harnessing the body’s potential with RNA medicine. Using Stoke’s proprietary TANGO (Targeted Augmentation of Nuclear Gene Output) approach, Stoke is developing antisense oligonucleotides (ASOs) to selectively restore naturally-occurring protein levels. Stoke’s first medicine in development, zorevunersen, has demonstrated the potential for disease modification in patients with Dravet syndrome and is currently being evaluated in a Phase 3 study. Stoke’s initial focus are diseases of the central nervous system and the eye that are caused by a loss of ~50% of normal protein levels (haploinsufficiency). Proof of concept has been demonstrated in other organs, tissues, and systems, supporting broad potential for Stoke’s proprietary approach. Stoke is headquartered in Bedford, Massachusetts. For more information, visit

Position Purpose:

The Senior Manager, Commercial Data Governance & Management will lead the governance, stewardship, and operational management of commercial data assets across the organization. Reporting to the Executive Director, Integrated Commercial Data Strategy & Launch Analytics, this role will establish and maintain governance processes, business rules frameworks, metadata management capabilities, and data catalog infrastructure needed to ensure commercial data is trusted, documented, discoverable, and fit for purpose. This position serves as the lead for Commercial Data Governance, Data Stewardship, Business Rules Governance, Metadata Management, and Data Catalog Management.

Key Responsibilities:

Commercial Data Governance

• Develop and maintain the commercial data governance framework.
• Establish policies, standards, and operating procedures across commercial data domains.
• Facilitate governance meetings and align definitions, standards, and accountability.
• Drive resolution of data ownership, quality, and standardization issues.
• Promote adoption of governance standards across commercial functions.

Master Data Stewardship & Data Quality

• Serve as a lead steward for HCP, Account, Site of Care, Payer, Territory, Affiliation, and Organizational hierarchies.
• Partner with IT and MDM platform owners to support governance and maintenance of master data assets.
• Coordinate hierarchy maintenance, account alignment, affiliation management, and reference data governance.
• Lead identification and resolution of data quality issues.
• Establish monitoring processes and scorecards for data quality.

Business Rules Governance

• Establish and maintain a centralized framework for documenting and governing commercial business rules.
• Create and maintain a repository supporting CRM, targeting, segmentation, patient services, market access, and analytics use cases.
• Develop processes for documentation, approval, testing, change management, and version control.
• Establish traceability between business requirements, rules, transformations, and reporting outputs.

Data Catalog & Metadata Management

• Lead implementation, maintenance, and adoption of the commercial data catalog strategy.
• Develop and maintain data dictionaries, business glossaries, metadata repositories, data inventories, and lineage documentation.
• Establish standards for documenting data assets, ownership, business definitions, and usage guidance.
• Improve commercial data literacy and discoverability of information assets.

Success Measures

• Established Commercial Data Governance Council and stewardship framework.
• Operational business rules repository.
• Commercial data catalog with documented data assets and metadata.
• Improved data quality transparency and issue management processes.

Required Skills & Experience:

• Bachelor’s degree required; advanced degree preferred.
• 7+ years of experience in Commercial Data Management, Data Governance, Commercial Operations, CRM Operations, Data Stewardship, or related biopharma functions.
• Experience implementing governance programs and stewardship frameworks.
• Experience with metadata, data catalogs, business glossaries, and data quality initiatives.
• Strong understanding of pharmaceutical commercial data sources.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Location(s):

This position is open to both on-site and remote work arrangements. Stoke is located in Bedford, MA, and will be moving to a new location in Waltham, MA by the end of 2026.

Travel:

This position will require approximately 5% travel.

Compensation & Benefits:

At Stoke Therapeutics, we are committed to offering a comprehensive, competitive and thoughtfully designed total rewards program.

The anticipated salary range for this role is $173,000 - $196,000. The final offer will be determined based on a variety of factors, including role scope, experience and qualifications, education, market benchmarks, internal equity, and geographic location. In addition to base salary, Stoke offers an annual bonus and equity participation.

Our benefits package includes medical, dental and vision insurance; life, long- and short-term disability insurance; paid parental leave; a 401K plan with company match, unlimited vacation time, tuition assistance and participation in our Employee Stock Purchase Program (ESPP).

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

For more information, visit

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.

Culture & Values:

At Stoke, we believe that innovation, the ability to successfully advance our ground-breaking science and having fun as a team are enhanced by being together in person, at least periodically. We allow for flexibility in work arrangements that balance individual’s needs and preferences with the needs of our business and our desire to foster a culture of collaboration and innovation.

Our values guide our work to deliver meaningful medicines for people who need them. We are committed to being true to ourselves, to our colleagues, and to the people with severe diseases who are counting on us. We embrace diversity within a unique culture that is defined by our values. Our employee-led Diversity, Inclusion, and Belonging (DIB) Committee underscores the importance of DIB to who we are and what we do.

Interested candidates: Please visit Stoke’s website to learn more and apply directly to the position listed on our Career Center:

For more information, visit

All applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, physical or mental disability or protected veteran status.

Stoke participates in E-Verify.