Principal Scientist, Peptide Chemistry
Third Rock Ventures
About the Company
A well-financed stealth Third Rock Ventures company is seeking an experienced Peptide Scientist to lead peptide design efforts supporting discovery-stage therapeutic programs. This role will focus on peptide SAR, data interpretation, and lead optimization, working closely with project leadership and cross-functional teams.
Responsibilities
- Lead and design strategies for peptide therapeutics to support early discovery programs
- Drive structure–activity relationship (SAR) efforts and guide molecule optimization
- Manage and oversee work conducted at external CRO partners, including peptide synthesis, analytics, and related studies
- Review and interpret experimental data to inform molecule design and program strategy
- Present program updates and recommendations to project teams
- Partner closely with project leads and cross-functional teams (biology, pharmacology, DMPK, CMC) to advance programs
- Help define external study plans, timelines, and priorities to support program milestones
Qualifications
- PhD in chemistry, chemical biology, peptide science, or related field
- Significant experience in therapeutic peptide discovery
- Expertise in metabolic or endocrine indications
- Demonstrated ability to guide molecule design and SAR strategy
- Track record of contributing to advancement of discovery programs
- Experience managing external CRO collaborations
- Strong communication skills and ability to present scientific strategy to multidisciplinary teams
Required Skills
- Experience in therapeutic peptide discovery and optimization
- Ability to guide peptide design and SAR strategy
- Strong communication skills
- Experience managing external CRO collaborations
- Ability to present scientific strategy to multidisciplinary teams
Location
- With offices in Boston, San Francisco and Shanghai, the ability to work from one of these locations, but we are open to remote employment for exceptional individuals able to work collaboratively and effectively
Equal Opportunity Statement
We are committed to diversity and inclusivity.
Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Principal Scientist, Peptide Chemistry in San Francisco, CA vacancy
$120k - $180k
Founding Scientist (Peptide Chemistry) San Francisco · Full-time · $120-180K depending on what you bring $10k referral bonus for successful hires (half equity, half cash). It's Monday, 10 AM. You walk through the glass doors at the San Francisco lab, grab a coffee, grab...SuggestedFull timeImmediate startNight shiftDay shiftAfternoon shift$124.3k - $230.9k
...are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory... ...our Synthetic Molecule Analytical Chemistry (SMAC) group. The successful candidate... ...for analysis of small molecules, peptides, oligonucleotides, polymers, or nanoparticles...PrincipalLocal areaRelocation packageF. Hoffmann-La Roche AG
South San Francisco, CA4 days ago$124.3k - $230.9k
...are seeking a highly motivated Senior Scientist or Principal Scientist with a strong record of laboratory... ...our Synthetic Molecule Analytical Chemistry (SMAC) group. This role is ideal for a... ...including synthetic small molecules, peptides, oligonucleotides, and drug delivery...PrincipalLocal areaRelocation packageGenentech
South San Francisco, CA17 hours ago$202.5k - $236.25k
...Principal Scientist, Computational Chemistry page is loaded## Principal Scientist, Computational Chemistrylocations: South San Francisco, Californiatime type: Full timeposted on: Posted Todayjob requisition id: R412Cytokinetics is a specialty cardiovascular biopharmaceutical...PrincipalCytokinetics
San Francisco, CA3 days ago$124.3k - $230.9k
Senior Scientist / Principal Scientist - Synthetic Molecule Analytical Chemistry We are seeking an experienced scientist with a strong record of laboratory innovation... ...for the analysis of synthetic small molecules, peptides, oligonucleotides, polymers, or nanoparticles:...PrincipalLocal areaRelocation package$144.9k - $269.1k
...Opportunity We are seeking an exceptional computational scientist to apply cutting‑edge computational science, focusing on peptide therapeutic discovery. The ideal candidate... ...a unique blend of expertise in computational chemistry, including machine learning, to drive the...PrincipalLocal areaRelocation package$168.6k - $313k
...motivated and experienced Medicinal Chemist (Senior Principal Scientist) to lead and mentor a multidisciplinary team in our Peptide Therapeutics department. The role will focus... ...: Ph.D. or postdoctoral degree in Organic Chemistry, Medicinal Chemistry, or a related field....PrincipalLocal areaRelocation packageF. Hoffmann-La Roche AG
South San Francisco, CA4 days ago$143.2k - $265.9k
A leading biotechnology firm in California is seeking a Principal Scientist, Medicinal Chemist to lead efforts in peptide therapeutics. This lab-based role requires a Ph.D. in Organic or Medicinal Chemistry along with expertise in peptide synthesis and computational modeling...Principal- Stealth Deep Tech in San Francisco is seeking a Founding Scientist specializing in peptide chemistry to lead groundbreaking research with the potential to set world records in drug development timelines. You'll manage peptide synthesis and testing, contributing directly...
$143.2k - $265.9k
F. Hoffmann-La Roche AG is seeking a Principal Scientist in Medicinal Chemistry to join their R&D team in South San Francisco, California. This pivotal... ...syntheses and leading multidisciplinary project teams in peptide therapeutics. The ideal candidate holds a Ph.D. in...PrincipalRelocation package$144.9k - $269.1k
Genentech is looking for an exceptional computational scientist in South San Francisco to drive peptide therapeutic discovery, leveraging advanced... ...ideal candidate will have a Ph.D. in Computational Chemistry and experience in peptide discovery. This role involves...PrincipalRelocation package$143.2k - $265.9k
...seeking a creative and highly motivated Principal Scientist, Medicinal Chemist to join our R&D... ...technical leadership position within the Peptide Therapeutics department. Key... ...peptide synthesis, solution‑phase organic chemistry, and specialized macrocyclization or ligation...PrincipalLocal areaRelocation packageF. Hoffmann-La Roche AG
South San Francisco, CA3 days ago$196k - $242k
...patients with cancer. Location South San Francisco, CA. Position Summary We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small molecule drug...PrincipalTemporary workLocal areaRemote work1 day per week$196k - $242k
...patients with cancer. Location: South San Francisco, CA. Position Summary We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small‑molecule drug...PrincipalTemporary workWork at officeLocal areaWork from home$196k - $242k
IDEAYA Biosciences, Inc. is looking for a Senior Principal Research Scientist in Computational Chemistry in South San Francisco, CA. This role involves leading drug design efforts and mentoring while applying computational methods to influence project outcomes. Working...PrincipalRemote job1 day per week$196k - $242k
IDEAYA Biosciences in South San Francisco is seeking a Senior Principal Research Scientist in Computational Chemistry. This senior individual-contributor role demands significant pharmaceutical industry experience, focusing on advancing drug discovery programs. Responsibilities...Principal$288.59k - $384.79k
Comcast is looking for a Sr Principal Scientist of Research & Optimization Sciences to lead a team of experts in machine learning and optimization. This role involves defining a research strategy for large-scale advertising systems and fostering innovation. The ideal candidate...Principal$203.75k - $298.7k
CaptivateIQ, located in San Francisco, is seeking a Principal Product Designer to spearhead design for its Incentive Compensation Management product line. This senior role demands expertise in designing complex B2B SaaS products, leading transformative initiatives while...Principal$130k - $157k
ADL (Anti-Defamation League) seeks a Principal Gifts Officer in San Francisco to cultivate high-value donor relationships and maximize fundraising efforts. The role requires strategic thinking and the ability to work collaboratively with senior leadership and program teams...Principal$186k - $233k
Revolution Medicines is seeking an experienced Statistical Programmer with over 14 years in oncology trials. The role entails leading studies, collaborating with teams, and overseeing programming support for regulatory submissions in a dynamic environment. This opportunity...Principal- Palo Alto Networks is seeking a Sr. Principal Security Researcher to lead the development of threat detection capabilities. You will shape methodologies and mentor junior researchers, all while driving innovative solutions for advanced malware protection. The ideal candidate...Principal
- CA For The Arts in San Francisco is looking for a Principal Gifts Officer, a vital role for managing top donors capable of significant contributions. This individual will handle a portfolio of 75-100 major gift prospects, building relationships and executing solicitations...Principal
- Airbnb, Inc. is seeking a Senior Principal in Marketing Strategic Finance & Analytics to lead financial strategy and analytics across marketing. This role involves budget management, KPI setting, and providing analytical insights to drive growth. Ideal candidates will have...Principal
- VC Stack in San Francisco is looking for a Principal-level investor to lead investment efforts and manage a team. This role requires at least 7 years of experience in venture capital, a proven track record of successful investments, and strong fundraising abilities. You...Principal
- Warner Media, LLC. is seeking a Senior Principal Product Manager to lead the strategy for Content Discovery. You will influence core customer experiences at a global scale and work with a dynamic team across various functions. The ideal candidate has over 5 years of experience...Principal
- PagerDuty, Inc. is seeking a Customer Success Manager based in San Francisco, California, to build trusted relationships with customers’ IT and Engineering teams. The ideal candidate will have 8-10 years of customer-facing experience, proficiency in IT enterprise architecture...PrincipalFlexible hours
- Sr. Principal RF Microwave Test/Validation Engineer POSTING DATE: 6.3.26 We are working on behalf of a leading maker of high-speed analog ICs, including TIAs and Drivers for Data Center applications. They are looking for an RF /Microwave Test/ Validation Engineer based...Principal
$180k - $215k
VC Stack is seeking a Senior Investment Principal in San Francisco to manage client portfolios and drive business development. The role requires 12+ years of experience in professional services, exceptional problem-solving skills, and the ability to lead and mentor junior...Principal$260k - $275k
Saviynt, located in San Francisco, is hiring a Senior Principal Software Engineer to lead the development of our AI security products. You will design and implement secure and scalable workflows, work across various cloud platforms, and contribute to product direction and...Principal$58k - $123.2k
...Position Summary This Postdoctoral Scientist position offers the opportunity to work directly on drug discovery programs with Lilly’s Medicinal Chemistry organization in South San Francisco within Lilly Small Molecule Discovery (LSMD) Team. The scientist will be embedded...Full timeFlexible hoursInitial Therapeutics, Inc.
San Francisco, CA3 days ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Principal Scientist, Peptide Chemistry. Be the first to apply!
Related searches
- research chemist San Francisco, CA
- lab chemist San Francisco, CA
- chemist San Francisco, CA
- principal scientist San Francisco, CA
- senior principal cloud computing engineer San Francisco, CA
- principal data scientist San Francisco, CA
- senior principal scientist San Francisco, CA
- principal cloud computing engineer San Francisco, CA
- associate principal San Francisco, CA
- principal architect San Francisco, CA