Sr Dir, Clinical Pharmacology & Pharmacometrics - Brisbane CA

Job Description

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Role Overview
Bristol Myers Squibb is seeking a strategic, scientifically grounded leader to serve as the Senior Director for Clinical Pharmacology & Pharmacometrics. This leader will partner deeply with Clinical Pharmacology, Pharmacometrics, Quantitative Pharmacology, and Translational Medicine stakeholders to deliver the applications, modeling environments, workflow automation, and governed operational capabilities that support CPP work end to end-from quantitative preclinical-to-clinical bridging through clinical PK/PD, dose and regimen decisions, and submission-support outputs.

This role supports the quantitative CPP layer across Research and Development, including pharmacometric workflows, clinical PK/PD systems, modeling platforms, reporting automation, regulatory evidence generation, and the governed operational capabilities required to run these workflows at scale.

Reporting to the Vice President, Research Business Insights & Technology, this leader will operate as part of a unified BI&T leadership team and act as a trusted partner to Research and Development leadership. The role carries accountability for the reliability, fit-for-purpose evolution, and long-term scaling of the CPP technology stack and workflow ecosystem, while working in a highly matrixed model with scientific leaders, data teams, lab-platform teams, and regulatory-facing partners.

Mission & Impact
Provide a scalable application and workflow backbone for CPP across preclinical-to-clinical translation, clinical PK/PD, dose selection, exposure-response, and model-informed development decisions
Improve the speed, quality, reproducibility, traceability, and inspection-readiness of pharmacometrics and clinical pharmacology workflows
Strengthen regulatory submissions through robust reporting, reusable quantitative evidence generation, and auditable outputs that support documents such as clinical pharmacology summaries and model-based appendices
Enable governed automation of priority CPP workflows, including reporting, simulation, execution, review, and knowledge reuse
Create a durable technology foundation for end-to-end CPP that can scale with pipeline demand and integrate cleanly across the broader Research and Development ecosystem
Sub-Areas in Scope
Clinical pharmacology and pharmacometrics applications, including population PK, PK/PD, exposure-response, dose optimization, and model-informed decision support
PBPK, QSP, drug-drug interaction, and other quantitative modeling environments used in CPP workflows
Clinical PK/PD systems and operational tooling that support end-to-end CPP execution
CPAR, Quarto-based or similar reporting automation, and submission-support workflows for quantitative regulatory deliverables
Quantitative translational workflows that bridge preclinical and clinical evidence in support of CPP decision-making
Workflow governance, audit trails, validation support, access controls, and inspection-ready operational practices for regulated quantitative environments
AI-enabled and advanced analytics capabilities that improve CPP workflow efficiency, simulation, review, reporting, and knowledge reuse
In partnership, but not sole ownership: translational labs, pathology, molecular and imaging lab workflows, CLIA-oriented lab operations, precision medicine diagnostics, and broad bioanalytical capabilities
Key Responsibilities
Serve as the single BI&T point of accountability for CPP technology, applications, workflows, and support services end to end
Partner across Research and Development to integrate CPP workflows with the scientific, data, and operational capabilities required for model-informed drug development
Own clinical pharmacology and pharmacometrics applications, modeling environments, reporting workflows, and operational support for core CPP use cases
Ensure operational excellence, reliability, governance, and continuous improvement across modeling environments, clinical PK/PD systems, reporting workflows, and submission-support applications
Lead automation of priority CPP workflows, including model execution, reporting, simulation, traceability, review, and evidence reuse
Support quantitative regulatory deliverables through fit-for-purpose tooling, reproducible workflows, and inspection-ready practices
Partner with Unified Lab & Experimental Platforms, Target & Disease Biology, and In-Vivo & Non-Clinical Pharmacology where translational science, lab systems, diagnostics, biomarker workflows, or bioanalytical capabilities intersect with CPP needs
Partner with the R&D Data organization on underlying data-product strategy, integration, and fit-for-purpose data access
Lead and grow a team of scientific technologists, product leaders, and specialized engineers aligned to this domain

Additional Qualifications/Responsibilities

Required Experience & Qualifications
Ph.D. in Pharmacometrics, Clinical Pharmacology, Pharmaceutical Sciences, Biostatistics, or related quantitative field
12+ years in pharmaceutical R&D with deep clinical pharmacology, pharmacometrics, and model-informed drug development experience
Proven experience implementing or leading CPP applications, PBPK and QSP environments, clinical PK/PD systems, or quantitative workflow automation
Demonstrated experience supporting regulatory submissions, quantitative reporting, and governed workflows in Development-facing settings
Experience applying AI/ML or advanced automation to quantitative modeling, reporting, or regulated scientific workflows is preferred
Director or Senior Director-level leadership experience; experience building and scaling a specialized scientific technology team is a strong differentiator
Critical Capabilities
Scientific Depth in Clinical Pharmacology and Pharmacometrics - Deep credibility with quantitative scientists and domain leaders across CPP
Strategic Partnership - Translates scientific and Development needs into practical, integrated technology and workflow solutions
Operational Leadership - Builds reliable, scalable, inspection-ready environments and support models for critical quantitative workflows
Regulatory Translation Capability - Understands how quantitative evidence is prepared, reported, reviewed, and used in regulatory settings
Leadership & Change Attributes
Strong partnership with senior scientific, clinical, and regulatory leaders
Comfort operating with regulatory and global Development stakeholders
Ability to recruit, develop, and retain highly specialized quantitative talent in a competitive market
Experience navigating matrixed organizations and building credibility quickly
Commitment to building a collaborative, high-performing culture in a growing team
What Differentiates Top Candidates
Experience as a clinical pharmacology or pharmacometrics technology leader inside a top-tier pharmaceutical R&D organization
Track record of applications, workflows, or platforms that improved dose selection, quantitative decision-making, or regulatory execution in Development-facing settings
Experience deploying workflow automation, AI-enabled capabilities, or advanced analytics in support of end-to-end CPP modeling, reporting, and decision-support operations
Demonstrated success building a specialized function from foundational capability to scaled organizational value while operating through strong matrix partnerships
Why This Role Matters Now
Bristol Myers Squibb is at a pivotal moment, reimagining how technology, data, and AI enable scientific decision-making across Research and Development. Clinical pharmacology and pharmacometrics sit at the center of that shift, shaping how teams translate preclinical insights, make dose and regimen decisions, generate regulatory evidence, and advance programs with greater speed and rigor. This role is central to building the next generation of CPP capabilities, ensuring that scientists have the tools, automation, and integrated workflows needed to improve quality, reuse, and accountability across the pipeline.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Compensation Overview:

Brisbane - CA - US: $252,640 - $306,137
Cambridge Crossing: $252,640 - $306,137
Princeton - NJ - US: $229,670 - $278,306
San Diego - CA - US: $252,640 - $306,137