Senior Director, Internal Medicine Portfolio Strategy Lead

Senior Director, Internal Medicine Portfolio Strategy Lead United States - Massachusetts - Cambridge United States - Pennsylvania - Collegeville United States - New York - New York City We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals. Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Everything we do, every day, is driven by an unwavering commitment to the patients, healthcare providers, and customers who depend on us. In Global Commercial Strategy (GCS), we translate science of R&D into value for patients and Pfizer — from early development through launch, growth, and LOE lifecycle. GCS serves as the strategic engine and commercial voice across the asset lifecycle — shaping asset positioning and evidence generation, leading global launches, and propelling brand performance through market and payer insights, broad efficient, and sustained access, and commercial rigor. We take pride in shaping how innovative medicines reach the people who need them most, and ensuring they are accessible, understood, valued, and appropriately utilized across every market. Our success is anchored in the following Pfizer Blueprint values: Science, Technology, Transformation and Colleagues. What You Will Achieve The Senior Director, IM Portfolio Strategy Lead is a senior individual contributor role within the Internal Medicine and Antivirals business, part of the Global Commercial Strategy organization, reporting to the VP, GCS, IM/AV. This role has no current direct reports and will lead through influence and senior matrixed leadership. The role is responsible for leading portfolio‑level strategy, prioritization, investment decision support, and enterprise‑ready strategic recommendations across the Internal Medicine and Antiviral portfolio. The colleague will bring deep commercial strategy experience, analytical rigor, scientific curiosity, and enterprise judgment to help shape portfolio choices, pipeline opportunities, lifecycle priorities, and external innovation strategy. The Internal Medicine and Antivirals portfolio represents significant strategic value to realizing Pfizer's vision to achieve leadership via breakthroughs in prioritized diseases to generate highly differentiated, multi‑indication mega‑blockbusters. Today, the portfolio delivers more than $11 B globally. This colleague will serve as a senior portfolio strategy partner to the VP, GCS, IM/AV, DALs, and cross‑functional leaders, helping translate scientific, clinical, market, access, competitive, and business insights into clear portfolio priorities and disciplined trade‑off decisions. The role will support strategic planning across near, mid, and long‑term horizons and ensure that portfolio recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, and enterprise value. This role requires an experienced commercial strategist who can operate across ambiguity, influence senior stakeholders without direct authority, and connect work across disease areas, assets, lifecycle opportunities, and external innovation. The Senior Director will help establish repeatable approaches, decision frameworks, and AI‑enabled ways of working that improve the quality, consistency, and speed of portfolio strategy development across Internal Medicine and Antivirals. Responsibilities Portfolio Strategy and Long‑Range Planning Lead development of long‑range commercial and portfolio strategy across the Internal Medicine and Antivirals portfolio, spanning pipeline assets, lifecycle opportunities, external innovation, and emerging disease‑area opportunities. Establish integrated near, mid, and long‑term views of portfolio opportunities, risks, and investment priorities to inform enterprise decision‑making. Synthesize scientific, clinical, commercial, access, competitive, financial, and patient insights to identify priority opportunities and strategic trade‑offs. Monitor shifts in the scientific, competitive, and market landscape to identify emerging trends, discontinuities, and implications for future Internal Medicine and Antivirals strategy. Translate portfolio strategy into clear recommendations, implications, and decision materials for leadership, governance forums, and cross‑functional portfolio discussions. Portfolio Prioritization and Investment Decision Support Provide senior commercial strategy leadership for portfolio prioritization, investment choices, and development opportunities across Internal Medicine and Antivirals priorities. Pressure‑test commercial assumptions, value drivers, risks, uncertainties, resource implications, and evidence needs that may influence future launch potential, lifecycle value, and portfolio performance. Lead development of executive‑ready materials that communicate strategic rationale, opportunity attractiveness, trade‑offs, scenarios, and recommended actions. Partner with cross‑functional leaders to align on key choices related to portfolio sequencing, indication prioritization, evidence generation, market development, and lifecycle opportunities. Support disciplined decision‑making by ensuring portfolio recommendations are grounded in patient need, scientific opportunity, market potential, access dynamics, financial impact, and enterprise value. Early Commercial Assessment and Product Concept Development Oversee early commercial assessments for pipeline assets, mechanisms, indications, disease‑area opportunities, and potential future product concepts across Internal Medicine and Antivirals. Guide development and refinement of product concepts, target product profile input, positioning hypotheses, market archetypes, commercial opportunity assessments, and forecast assumptions. Ensure unmet need, standard of care, competitive dynamics, patient/HCP insights, payer considerations, and access requirements are translated into differentiated commercial hypotheses. Provide portfolio‑level commercial input to clinical development, evidence generation, lifecycle, and indication sequencing discussions in partnership with cross‑functional colleagues. Build repeatable approaches for high‑quality early commercial strategy outputs, portfolio reviews, and decision‑support materials across Internal Medicine and Antivirals workstreams. Business Development and External Innovation Support Lead portfolio strategy input for external innovation and Business Development opportunities relevant to Internal Medicine and Antivirals. Guide assessment of strategic fit, market potential, valuation inputs, competitive scenarios, portfolio implications, and prioritization considerations for potential external opportunities. Partner with Business Development, R&D, GASP, BAI, and Competitive Intelligence colleagues to pressure‑test assumptions and identify key decision points. Represent the commercial portfolio strategy perspective in internal discussions related to external opportunities and broader Internal Medicine and Antivirals strategy as needed. Cross‑Functional Partnership and Governance Provide senior matrix leadership across cross‑functional partners, helping align priorities, clarify decision points, and strengthen high‑quality strategic outputs across Internal Medicine and Antivirals portfolio priorities. Partner with the VP, GCS, IM/AV, DALs, and cross‑functional leaders to ensure a strong commercial and portfolio strategy voice is incorporated into early development, portfolio, and investment decisions. Influence without direct authority by aligning stakeholders around shared insights, strategic choices, and implications for the Internal Medicine and Antivirals portfolio. Build trusted working relationships across R&D, Medical Affairs, GASP, BAI, Competitive Intelligence, Business Development, Finance, and Commercial Regions. Foster a culture of enterprise thinking, scientific curiosity, disciplined prioritization, accountability, and collaboration across cross‑functional workstreams. AI‑Enabled Ways of Working Set expectations for responsible, AI‑enabled ways of working across portfolio strategy workstreams to improve speed, quality, consistency, and scalability of strategic outputs. Champion use of AI‑enabled tools to support scientific and competitive landscape synthesis, market insight generation, scenario development, prioritization, and decision‑support efficiency. Help build cross‑functional capability and confidence in compliant, AI‑augmented strategy development through best‑practice sharing and reinforcement of quality standards. Identify opportunities to embed AI into repeatable workflows, templates, portfolio reviews, scenario planning, and strategic decision‑support processes. Use performance insights, stakeholder feedback, and workstream learnings to continuously improve AI‑enabled ways of working across portfolio strategy activities. Here Is What You Need (Minimum Requirements) Applicant must have a bachelor's degree with at least 12 years of experience; OR a master's degree with at least 10 years of experience; OR a PhD with 7+ years of experience. Experience in pharmaceutical, biotechnology, life sciences, commercial development, portfolio strategy, corporate strategy, business development, forecasting, market research, analytics, or related field. Demonstrated experience leading complex cross‑functional initiatives, influencing in matrixed environments, and shaping senior‑level portfolio or investment decisions without direct authority. Strong strategic and analytical skills, with ability to synthesize complex scientific, clinical, market, access, and competitive information into clear recommendations. Experience leading portfolio strategy, early commercial assessment, business case development, opportunity assessment, investment prioritization, or cross‑functional strategic planning. Ability to engage in scientific and clinical dialogue and translate implications for commercial opportunity, differentiation, portfolio value, and enterprise decision‑making. Strong communication, executive presence, problem‑solving, and stakeholder management skills. Bonus Points If You Have (Preferred Requirements) Experience in Internal Medicine, Antivirals, cardiometabolic disease, specialty care, primary care, or other complex therapeutic areas preferred. Experience with commercial development, early asset strategy, portfolio management, Business Development assessments, launch strategy, lifecycle strategy, or corporate strategy. Demonstrated ability to develop long‑term strategies for products, disease areas, or portfolios and secure alignment from senior leadership. Understanding of market access dynamics, payer considerations, evidence generation, value demonstration, and lifecycle value optimization. Track record of leading cross‑functional initiatives, influencing without authority, acting decisively, and making recommendations with incomplete, imperfect or disparate information. Comfort working in an AI‑enabled or AI‑augmented environment; experience using AI tools to support strategy, synthesis, or analysis is a plus. Ability to thrive in ambiguity, operate with enterprise mindset, and adapt to evolving portfolio priorities. Robust operational experience vs. building tactical plans to pull through strategic priorities, negotiating optimal OpEx and AI investment in the go‑to‑market model and promotional plans spanning core and innovative commercial levers, preserving or improving CoGS and gross‑to‑net liability. Discretion, sound judgment, and trustworthiness in handling confidential or sensitive organizational matters. The annual base salary for this position ranges from $214,900.00 to $358,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share‑based long‑term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits. Work Location Assignment: Hybrid Relocation assistance may be available based on business needs and/or eligibility. Candidates must be authorized to be employed in the U.S. by any employer. U.S. work visa sponsorship (such as TN, O‑1, H‑1B, etc.) is not available for this role now or in the future. Sunshine Act Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider’s name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. EEO & Employment Eligibility Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E‑Verify employer. This position requires permanent work authorization in the United States. Accessibility Pfizer endeavors to make accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email View email address on click.appcast.io. 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