Principal Scientist - Semantic AI for Drug Discovery
Scorpion Therapeutics
Scorpion Therapeutics in Cambridge, MA, seeks a senior Biomedical Informatics Architect to establish semantic foundations for AI-driven reasoning across discovery, preclinical, and clinical development. You will lead ontology governance, build RDF-based knowledge graphs, and harmonize translational data (SEND, SDTM, ADaM, MedDRA, FHIR) while partnering with research and engineering teams. #J-18808-Ljbffr Scorpion Therapeutics
- Position Summary Design and implement semantic/knowledge architecture enabling AI-driven reasoning across the drug discovery and development lifecycle. Mission Build the semantic foundation for AI systems to reason across discovery, preclinical, clinical, and post-marketing...Principal
- ...a scientific leader to accelerate the application of AI and agentic systems across drug discovery. Working at the intersection of Computational Drug Design... ...translate them into scientifically rigorous AI co-scientists that enhance compound design, knowledge synthesis,...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week
$119.7k - $222.3k
...of artificial intelligence (AI) enabled strategies to transform... .... Experience in late discovery into clinical development is... ...therapeutic proteins, antibody drug-conjugates, radioligand therapies... ...strategy, to be considered for Principal Scientist II. 4+ years of experience to...PrincipalFull time- ...senior data product architect to design and evolve AI-ready scientific data products supporting drug discovery and development. You will connect discovery,... ...data products and governance. You will partner with scientists, knowledge architects, AI engineers, and platform...Principal
- Pioneering Intelligence is seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects across preclinical to clinical R&... ...platforms, and agent orchestration to accelerate discovery and translation within Flagship's ecosystem. #J-1...Principal
$119.7k - $222.3k
...of artificial intelligence (AI) enabled strategies to transform... .... Experience in late discovery into clinical development is... ...therapeutic proteins, antibody drug-conjugates, radioligand therapies... ...strategy, to be considered for Principal Scientist II. 4+ years of experience to...Principal$166.77k - $202.09k
...lives. Read more: careers.bms.com/working-with-us. Principal Scientist, AI-Driven Oncology Target Discovery The Informatics and Predictive Sciences (IPS) mission... ...epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic...PrincipalHourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work- ...scientific data products and integration strategies supporting AI-enabled drug discovery and development. Create scalable, interoperable, AI-ready... ..., metadata framework, and productization approach for semantic reasoning, knowledge graphs, GraphRAG, advanced analytics,...PrincipalImmediate start
$115k - $215k
...targeted proteomics strategies that inform discovery, translational, and clinical-stage decision making within fast-paced drug discovery environments.Development and deployment... ...:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsLocation... ..., you will help shape the future of drug discovery and development across Sanofi's... ...where deep immunoscience meets bold, AI-powered research. In R&D, you’ll drive...PrincipalFull time- Job DescriptionVertex is seeking an accomplished Senior Principal Scientist with proven record of developing, testing and deploying scientific computational methods and agentic AI systems for drug discovery. In this role, you will work across modalities with emphasis on...PrincipalFull timeSummer workRemote workFlexible hours2 days per week3 days per week
$198.9k - $269k
...looking for researchers who aim to build super-intelligent AI systems that leverage proof assistants to guide learning and... ...will join the team at the forefront of this research.As a Principal Applied Scientist, you will play a pivotal role in shaping the definition, vision...PrincipalFlexible hours$126k - $234k
..., CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The... ...evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. This is a labhead-based position, where the ideal...PrincipalFull timeRemote work- ...closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing... ...leadership and strategic guidance to advance programs from discovery through clinical development.Work arrangement: This is an...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours
$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge,... ...cellular resolution and pioneer AI-powered workflows that accelerate the path from discovery to patient impact. Ready to... ...to key decision points in the drug discovery process. Opportunities...PrincipalFull time$108.5k - $201.5k
Job Description Summary#LI-OnsiteInternal job title: Principal Scientist ILocation: Cambridge, United StatesWe are seeking a motivated soluble... ...Essential Requirements:PhD with 2+ years of experience in drug discovery, translational research, or related field; or Master’s...PrincipalFull time$216k - $297k
...harnessing recent advances in AI, machine learning, and data to... ...of talented machine learning scientists innovating on model architectures... ...-of-action reasoning, target discovery, perturbation biology, pathway... ..., AI-for-biology, AI-enabled drug discovery, translational data...Principal- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...Principal
$176.2k - $277.3k
...and Bioanalytics (PDMB) group is seeking a dynamic, strategic thinking and collaborative Principal Scientist (director-level equivalent) to contribute to our company drug discovery and early clinical development efforts. This position will be based at our research labs...PrincipalFull timeFor contractorsLocal areaWorldwideFlexible hours$137k - $215.27k
...seeking a skilled cheminformatic scientist to join Takeda’s... ...machine learning to accelerate drug design. The candidate will collaborate... ...medicinal chemistry, DMPK, and AI/ML, defining a roadmap for computational... ...agentic AI solutions for drug discovery, including autonomous or human...Minimum wageLocal area- ...technology have finally made it possible for AI to impact clinical care in a meaningful... ...research and industry trends in oncology drug development, and identify specific areas where... ...of multimodal analysis and AI in drug discovery in coordination with our Research, Engineering...PrincipalFull timeRemote workShift work
- ...expanding the team of talented scientists who seek to build the future of small molecule drug discovery with creativity and innovation... ...Scientist/Senior Scientist/Principal Scientist to lead GPCR protein... ...design tools (e.g., Rosetta, AI/ML-driven prediction). Benefits...Principal
- Flagship Pioneering, Inc. is seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational initiatives accelerating pharmaceutical R&D across preclinical to clinical stages. You will define pragmatic AI strategies and oversee method and platform...Principal
$108.5k - $201.5k
...potential to transform patients’ lives around the world. As a Principal Scientist I or II, Oligonucleotide Chemistry and Innovation, you... ..., technical expertise, and innovation to the forefront of drug discovery. Working alongside a collaborative team of world-class scientists...PrincipalFull timeLocal areaWorldwideFlexible hours$114.1k - $211.9k
...medicine, molecular biology, or related discipline.7+ years of experience in translational research, biomarker strategy, biomarker discovery, or drug development within the pharmaceutical or biotechnology industry.Demonstrated experience developing biomarker strategies...PrincipalFull timeLocal areaFlexible hours$122.25k - $176.58k
...R2857588 Job title : Principal Scientist ~ Location: Waltham, MA... ...deep immunoscience meets bold, AI-powered research. In R&D, you... ...that engages patients early in drug development and uses their insights... ...at the forefront of drug discovery, harnessing cutting-edge AI,...PrincipalFull time- ...Computational Chemist to join the Computational Drug Design group. You will lead computational strategies for hit/lead discovery and optimization, collaborating with... ...group providing support for data analysis and AI method development. A Ph.D. #J-18808-Ljbffr Vertex...Principal
$190.8k - $300.3k
...Job Description The Nonclinical Drug Safety (NDS) Therapeutic Area Leader (TAL) is a senior scientific... ...through close collaboration with Program Coordinators, Discovery Preclinical Leaders, Compound Leaders, and scientists across NDS and/or Preclinical Development, while...PrincipalFull timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work- We are seeking a Senior Principal Scientist to join the US Neuromuscular group based in Cambridge, MA and help drive translational biology drug discovery efforts with an emphasis on muscle biology . This is an opportunity for a scientific leader to advance portfolio projects...PrincipalLocal area
$170k - $200k
...hands-on experience advancing discovery programs from hit identification... ...based and computational-based drug design to optimize peptide and... ...with machine learning and AI-driven platforms in drug discovery... ...and passionate team of scientists Be a part of a cutting-edge...Principal
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