Sr. Scientist I (Novel Biologic Entities- Bioanalysis and Translational Science Group- QTAS)

Company Description About AbbVie AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube. Job Description The Quantitative, Translational ADME Sciences (QTAS) department at AbbVie is seeking a highly motivated scientist to join the Novel Biologic Entities-Bioanalysis and Translational Science group. The main function of this position is to develop and implement LC/MS (liquid chromatography/mass spectrometry)-based bioanalysis and characterization assays of novel biologics entities. The successful candidate will be experienced in the optimization and implementation of novel and routine LC/MS-based bioanalytical methods for protein and proteome characterization and quantitation to support in vivo PK, TK, and PK/PD studies as well as in vivo stability characterization of complex biotherapeutic modalities. The candidate will be responsible for sample preparation, method development, bioanalytical assay operations, data analysis, report generation, and data presentation. Key tasks and responsibilities: Operate and maintain LC/MS instruments to generate high-quality experimental data. Perform affinity purification of biotherapeutic (including but not limited to monoclonal and multispecific antibody, antibody drug conjugates, Fusion Proteins, antibody-siRNA conjugates, and tLNPs). Perform proteomics/immunopeptidomicssample preparationworkflows Analyze data and maintain detailed, accurate and comprehensive study documentation in electronic laboratory notebooks. Communicate data interpretation internally and externally. Facilitate assay optimization and implementation to ensure laboratory capacity and data quality. Generate new scientific proposals and leadresultingefforts. Investigate,identify, develop, andoptimizenew methods and techniques. Act as a lead scientist in his/her area of expertise and critically evaluate relevant scientific and regulatory advances and integrate this knowledge into research or development programs. Qualifications Ph.D. (0+ years), M.S. (8+ years), or B.S. (10+ years) of experience in pharmaceutical or biotechnology industry. Highly motivated, self-driven and results-oriented with excellent communication and presentation skills; capable of working both as a team player and individual contributor. Prior industry experience in drug discovery/development is preferred. In-depthunderstanding of in vivo PK, TK and PK/PD studies and corresponding bioanalytical assays as well asin vitro/ in vivo characterization assays is highly desired. In-depth understanding of LC-MS methodology with the focus on protein mass spectrometry and hands-on experience with wide range of mass spectrometers, including QQQ, TOF and orbitrap platforms, are highly desired. Hands-on experience with proteomics/immunopeptidomicssamples preparationas well as automated liquid handling systemsis strongly preferred. Demonstrated ability to manage and analyze data using advanced software tools such as Protein Metrics Byos and GraphPad Prism. Passion for generating ideas, learning, solving technical problems, and applyingnew technologiesto advance scientific goals. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible toparticipatein our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: #J-18808-Ljbffr Allergan