Scientist 3 - Translational Medicine, Oncology

Genentech's Translational Medicine Oncology (TM ONC) Department supports the entire R&D portfolio of novel therapies. We develop and implement biomarker strategies to study disease pathways, confirm a therapeutic's mechanism of action, and improve clinical trial efficiency and success. Biomarker scientists within our department are responsible for conducting biomarker discovery, developing biomarker strategies, designing and implementing biomarker assays, and interpreting biomarker results. Additionally, we conduct foundational clinical translational research to study the molecular and cellular pathways driving disease to generate novel target and biomarker approaches. The Opportunity As a scientist in Translational Oncology, you will drive hands-on, lab-based translational research and discovery efforts in lung and gastrointestinal (GI) cancers. This is an exciting opportunity to contribute to one of the fastest-moving areas in oncology, where rapid advances in RAS-targeted therapies are transforming the treatment landscape and creating unprecedented opportunities for biomarker discovery and translational innovation. Working within a vibrant, highly collaborative environment alongside experts across Research Oncology, Computational Sciences, and Translational Genomics and Proteomics, you will bridge foundational science and clinical impact to accelerate new therapeutic strategies. Drive Hypothesis Validation: Design and execute laboratory experiments to validate biological and therapeutic hypotheses derived from non-clinical, clinical, and real-world data. Analyze High-Dimensional Data: Synthesize, analyze, and interpret experimental and computational data in close collaboration with functional domain experts. Decipher Disease Mechanisms: Investigate the molecular mechanisms underlying disease progression, therapeutic response, and acquired resistance to targeted therapies (e.g., RAS inhibitors) to inform patient selection, pharmacodynamic biomarker assessment, and combination treatment strategies. Innovate Assay Platforms: Identify, evaluate, and validate innovative cell-based, biochemical, and multi-omic assays, including single-cell and functional genomics technologies, to enable scalable hypothesis testing. Build Strategic Partnerships: Proactively establish strategic research collaborations to access emerging technologies, datasets, and analytical methods that fuel translational innovation. Collaborate for Impact: Partner seamlessly across multi-disciplinary teams to translate scientific insights into meaningful therapeutic opportunities for patients. Who You Are You are a dedicated, curious scientist with a creative and rigorous approach to experimental design and problem-solving. You thrive in a fast-paced, collaborative team culture where diverse perspectives drive innovation. Education & Experience Ph.D. in Cancer Biology, Cell Biology, Molecular Biology, Genetics & Genomics, or a related discipline (or a Bachelor's degree with 6+ years / Master\'s degree with 4+ years of relevant research experience). Scientific Expertise: Deep understanding of cancer biology, mechanisms of action and resistance to targeted therapies, and oncogenic signaling pathways (e.g., RAS/MAPK), alongside foundational knowledge of cancer immunology and the tumor microenvironment. Technical Proficiency: Demonstrated ability to independently lead laboratory research using methods such as genome editing, genetic/chemical perturbation screening, cell-based/biochemical assays, cell culture and organoid models, flow cytometry, spatial omics, or single-cell technologies. Proven Track Record: Demonstrated scientific contributions through peer-reviewed publications, patents, or impactful research accomplishments. Preferred: Data Analysis Skills: Familiarity or proficiency with the computational analysis of high-throughput data (such as multi-omics, single-cell, or spatial transcriptomics datasets). Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases. Relocation benefits are not available for this posting. The expected salary range for this position based on the primary location of California is $100,400 - $186,400. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits #TMONC Global Grade - SE6 Please note that the global grade displayed is a target global grade for the role and the actual global grade offered to a candidate may vary depending on several factors - including scope and breadth of the role. For further information relating to global grading in Roche please visit the global grading gSite. Roche is dedicated to ensuring fair and transparent pay practices for its employees. In compliance with state legal requirements, you may notice some of our job postings will now list salary ranges. Please note that the broad ranges are aligned with our global grading framework and, in some cases, may also include geographic differentials. As you consider making a change within the organization, this can include not only roles and responsibilities, but also an impact to compensation and benefits. Please take time to review Employees on the Move gSite to understand more. Roche is an equal opportunity employer. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company\'s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. Who We Are Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world\'s most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours. To apply today, click on the "Apply for this job" button. Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company\'s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr F. Hoffmann-La Roche AG