Principal Product Designer

Principal Product Designer

Remote, USA

At Twin Health, we empower people to improve and prevent chronic metabolic diseases, like type 2 diabetes and obesity, with a new standard of care. Twin Health is the only company applying AI Digital Twin technology exclusively toward metabolic health.

We start by building a dynamic model of each person's metabolism — drawing on thousands of data points from CGMs, smartwatches, and meal logs — that maps their personal path to better health. Guided by a dedicated clinical care team, our members have lowered their A1C below the diabetes range, achieved lasting weight loss, and reduced or even eliminated medications, all while living healthier, happier lives.

Join us as we reinvent the standard of care in metabolic health.

Opportunity

As a Principal Product Designer, you'll own the end-to-end experience strategy for our mobile app — the primary touchpoint where members manage their health every day. But more than that, you'll be doing something very few designers get to do: inventing the interaction language for agentic AI in healthcare from scratch.

There is no established playbook here. Agentic experiences — where AI acts autonomously on a user's behalf, surfaces proactive guidance, and adapts in real time to behavior and health data — are among the least explored frontiers in product design today. You'll be the person who figures out what these patterns look, feel, and behave like for people managing chronic conditions. That requires genuine originality, comfort with ambiguity, and the creative confidence to propose something that has never existed before.

This is the highest craft and leadership bar we hire to. You'll be a recognized thought leader internally — setting the quality standard others aspire to, shaping product roadmaps beyond your immediate scope, and leaving a design legacy that outlasts any single feature.

This isn't iteration work. It's an invention.

Responsibilities

Vision & Strategy

• Identify and drive mission-critical design initiatives with significant scope and long-term timelines — projects that directly shape the trajectory of the business, not just the product.
• Pioneer agentic UX from 0 to 1 — design entirely new interaction patterns for AI systems that act proactively, make recommendations, and operate with increasing autonomy on behalf of users. You'll be defining conventions that don't yet exist, not referencing ones that do.
• Assist stakeholders across teams in shaping their product roadmaps, bringing a design-led perspective to decisions that extend well beyond your own areas of ownership.
• Lead design strategy across interconnected member journeys — from onboarding through long-term behavior change — defining what "great" looks like, aligning cross-functional partners around it, and seeing it through to shipped product.

Innovation & Problem Solving

• Invent in uncharted territory — bring a high degree of creative originality to problems with no obvious solution. Concept, prototype, and validate novel design patterns that balance AI agency with user trust, transparency, and control.
• Lead high-complexity initiatives end to end while also serving as a design consultant across smaller-scale efforts, applying your breadth of experience to raise quality across the board.
• Drive innovation workshops and ideation exercises that push teams past familiar solutions and toward genuinely new design territory.

Craft & Execution

• Set the quality bar for design at Twin. Your work is the standard others reference — in interaction design, visual design, copy direction, and systems thinking.
• Translate clinical complexity and AI-generated insights into experiences that feel intuitive and motivating, designing for real health outcomes.
• Own the full craft end to end: information architecture, interaction design, visual design, copy direction, and user validation — from early concepts to pixel-perfect specs.
• Proactively identify visual, accessibility, and interaction issues across products and influence their prioritization and resolution.
• Be a steward and builder of Twin's design system — identifying gaps, leading improvements, and establishing new agentic design patterns as reusable components the broader team can build on.

Collaboration & Leadership

• Operate as a mentor and guide for designers and cross-functional partners — helping them advocate for best practices and elevating the craft and standards of the entire team.
• Develop and maintain strong relationships with senior stakeholders and executive leaders, negotiating and persuading with clarity, humility, and well-crafted rationale.
• Define and run research that uncovers unmet needs and validates direction, turning qualitative insights into clear, actionable design decisions.
• Communicate and storytell with expert fluency — you can defend a novel design concept in front of clinicians, engineers, and executives with equal confidence.

Impact

• Make contributions that exceed the expected boundaries of a product design role — positively influencing business health, product direction, and the design culture at Twin.
• Evolve how design functions at Twin, continuously recalibrating the team's approach based on business needs, industry shifts, and the frontier of AI-powered product design.
• Other duties as assigned

Qualifications

• 10+ years of product/UX design experience, with a portfolio that demonstrates the highest level of craft across interaction design, visual design, and systems thinking.
• Demonstrated experience designing agentic AI experiences — products where AI takes action, surfaces proactive interventions, or operates with agency rather than simply responding to user input.
• Proven ability to design 0-to-1 — you've created original interaction patterns in spaces with no prior art and can articulate the thinking and process behind how you got there.
• Highly inventive and creatively courageous — you don't default to what's familiar. You push into genuinely new territory and have a track record of work that others in the industry reference.
• Recognized thought leader in design — internally and externally — whose perspective carries weight beyond your immediate team.
• Expert communication and storytelling skills — able to negotiate with and persuade leaders at all levels while consistently acting with humility and without ego.
• High degree of independence and ingenuity when solving critical design challenges, with a track record of identifying and executing on new opportunities without waiting to be directed.
• Bachelor's degree in Design, HCI, or a related field — or equivalent experience.
• This remote opportunity based out of the U.S. Applicants must be authorized to work for any employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.

Nice to Have

• Hands-on experience with LLM prompting as part of a design or prototyping workflow — you've used AI as a creative tool, not just designed around it.
• Experience establishing design patterns for AI transparency, explainability, or human-in-the-loop interactions.

Compensation and Benefits

The compensation range for this position is $220,000 - $240,000 annually.

Twin has an ambitious vision to empower people to live healthier and happier lives, and to achieve this purpose, we need the very best people to enhance our cutting-edge technology and medical science, deliver the best possible care, and turn our passion into value for our members, partners and investors. We are committed to delivering an outstanding culture and experience for every Twin employee through a company based on the values of passion, talent, and trust. We offer comprehensive benefits and perks in line with these principles, as well as a high level of flexibility for every Twin

• A competitive compensation package in line with leading technology companies
• A remote and accomplished global team
• Opportunity for equity participation
• Unlimited vacation with manager approval
• 16 weeks of 100% paid parental leave for delivering parents; 8 weeks of 100% paid parental leave for non-delivering parents
• 100% Employer sponsored healthcare, dental, and vision for you, and 80% coverage for your family; Health Savings Account and Flexible Spending Account options
• 401k retirement savings plan

Salary range for US jobs

US Salary Range

$220,000 - $240,000 USD

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