Senior Director / Vice President of Program Management

Senior Director/Vice President, Program Management

About Axonis Therapeutics:

Axonis Therapeutics is a Boston-based, neuro-focused biotechnology company developing a portfolio of first- and best-in-class medicines targeting KCC2, a genetically validated critical mediator of inhibition within the brain. Axonis has brought together a collaborative, creative and determined team of world-leading experts in neuroscience and drug development to discover and develop novel treatments for epilepsy, pain and other neurological disorders. With its proprietary KCC2 discovery engine based on breakthrough science from Boston Children’s Hospital, Harvard and Laval University, Axonis is poised to make a real difference for patients, their families, and the global healthcare system.

The Role:

Axonis Therapeutics, Inc. is seeking an exceptional Senior Director / Vice President of Program Management to join its growing team. Axonis is a Boston-based biotechnology company advancing breakthrough drug discoveries to treat neurological disorders. Our lead program is a portfolio of first- and best-in-class oral small molecule drugs targeting KCC2, the chief CNS-specific chloride transporter essential for neuron inhibition, to treat epilepsies, chronic pain and other neurological disorders. The full-time role will report to the CEO. The position will be located in Boston, MA.

Responsibilities:

• Provide strategic leadership and oversight across early-stage development programs, ensuring alignment with company objectives and timelines.
• Lead development of program strategy and deliver integrated program plans, including objectives, timelines, budgets, and key development milestones.
• Oversee non-clinical and clinical data deliverables, including reports and decks, for investor communication.
• Establish and manage program governance structures (e.g., Core Teams, Sub-teams), ensuring clear accountability, decision-making, and documentation of key actions and decisions.
• Facilitate cross-functional collaboration with Discovery, Nonclinical, Clinical, Regulatory, and CMC leads to ensure alignment of strategy, deliverables, and risk mitigation plans.
• Facilitate regular project meetings with key stakeholders, including consultants/CROs, to assess program performance and address higher scope challenges.
• Lead preparation and presentation of program updates, risk/benefit analyses, and strategic recommendations to executive leadership and the Board.
• Champion operational excellence by implementing best practices, tools, and processes to enhance program efficiency, transparency, and decision-making.
• Develop and maintain databases and electronic filing systems to organize documentation of non-clinical projects and optimize team efficiency and quality of outcomes.
• Coordinate and manage external consultants and non-clinical CRO’s to ensure timely project delivery within scope and budget, while effectively communicating changes to internal and external stakeholders.
• Conduct scouting and selection of non-clinical CROs and Vendors, and facilitate implementation of MSAs/SOWs.

Required Skills & Qualifications:

• PhD in a related scientific discipline with 5+ years of experience, or Master’s Degree with 7+ years, or Bachelor’s Degree with 10+ years’ of experience in managing and/or supporting non-clinical projects in relevant areas.
• Prior regulatory submission experience essential for this role.
• Experience managing overall Program Timelines, including non-clinical, clinical, CMC.
• Ability to uphold internal and external milestones and streamline R&D performance.
• Strong collaboration, relationship-building skills and entrepreneurial spirit equipped with an ability to integrate across all company projects and achieve desired goals.

Preferred Skills & Qualifications:

• Understanding of financial aspects, including knowledge of resource planning (headcount and budget) and management.
• Extensive experience in small biotech companies.
• Small molecule experience.
• PMP certification.

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