Senior Associate Scientist

Job Title: Senior Associate Scientist- Vaccine Location: Waltham, MA About the Job: We are seeking a highly motivated and scientifically rigorous individual to join the Plasmid Production Pilot team. You will focus on execution and scale-up of a robust pDNA production process focusing on bacterial cell lysis, supercoiled plasmid DNA linearization, and purification for preclinical linearized plasmid DNA production, with the ultimate goal of transferring at scale methods to either the internal or external manufacturing team for mRNA drug substance with applications towards vaccine development. Join the team protecting half a billion lives every year with next-gen science, mRNA innovation, and AI-driven breakthroughs. In Vaccines, you’ll help advance prevention on a global scale - and shape the future of immunization. About Sanofi: We're an R&D-driven, AI-powered biopharma company committed to improving people’s lives and delivering compelling growth. Our deep understanding of the immune system - and innovative pipeline - enables us to invent medicines and vaccines that treat and protect millions of people around the world. Together, we chase the miracles of science to improve people’s lives. Main Responsibilities: Evaluate, and implement purification technology and optimize existing techniques and workflows. Support the execution and optimization of plasmid DNA purification, problem solving. Design and execute decision-quality research; prepare/draft SOPs, technical reports, batch record, and presentations to management and other stakeholders. Work independently, pro-actively, and be an impactful contributor to project teams. Function in highly collaborative cross functional teams. Execute ~20 batches per year. This will be primarily a lab-based position. About You: Basic Qualifications: Education: Bachelor's OR Master's degree in Biotechnology, Chemistry, Chemical Engineering, Biomedical Engineering, or related scientific field Experience: Bachelor's degree holders: Minimum 3+ years of relevant industry experience in pharma, biotech, or laboratory settings Master's degree holders: Minimum 1+ year of relevant industry experience in pharma, biotech, or laboratory settings Hands-on experience with HPLC (High-Performance Liquid Chromatography) operations Wet lab experience, particularly with fermentation or purification processes (plasmid DNA, protein, or similar) Preferred Qualifications: Hands-on experience in small- and large-scale plasmid DNA extraction and purification methodologies including alkali lysis, chromatography separation (anion exchange, hydrophobic interaction) and buffer exchange methods Familiar with Cytiva AKTA Pilot and Repligen TFF system (K2Ri and KMPi) Familiar with Sartorius PATfix system Prepare buffers for purification process Familiar with equipment setup, process troubleshooting and maintenance and experience in GLP environment is advantageous Works collaboratively within group for improved operational excellence as well as within interdisciplinary teams Desire to work in a team-first, fast-paced environment, learn new technologies and skills, and to efficiently solve problems Excellent organizational and communication skills Attention to detail & meticulous record keeping Demonstrate continuous growth in depth and breadth of personal scientific knowledge and understanding of strategic goals of group, team, and company Why Choose Us? Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks' gender-neutral parental leave. Work at the forefront of AI-driven research, smart manufacturing, and groundbreaking mRNA platforms that are redefining the future of immunology. Help protect half a billion people every year, contributing to one of the largest global vaccination efforts in healthcare. Develop your career with access to mentoring, international mobility programs, and opportunities to grow across four continents. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and affirmative action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs, and additional benefits information can be found here. #J-18808-Ljbffr Sanofi