Principal Scientist, Oligonucleotide (PMO, ASO) Development
Dyne Therapeutics
Principal Scientist leading chemical synthesis strategy for PMO and modified ASO oligonucleotide payloads at a neuromuscular disease-focused biotech. The role encompasses process development, analytical characterization, CDMO management, and regulatory strategy from preclinical through GMP manufacturing for IND-enabling studies.
Responsibilities
- Lead chemical synthesis strategy and execution for PMO and modified ASO molecules internally and with CDMOs
- Oversee preclinical process development, analytical development, and GMP manufacturing for IND-enabling studies
- Serve as primary technical lead for external CDMO partners and drive aggressive development timelines
- Develop CMC strategies and contribute to global regulatory filings including IND and IMPD submissions
- Ensure manufacturing processes are scalable, robust, and cost-effective while supporting bioconjugation platform optimization
Requirements
- Extensive experience in oligonucleotide chemical synthesis and process development
- Demonstrated expertise managing external CDMOs and manufacturing partnerships
- Strong background in analytical development and GMP manufacturing processes
- Knowledge of CMC strategy and regulatory filings (IND, IMPD, similar)
- Experience with PMO and/or modified ASO platform development or scale-up
- Leadership experience in matrix-driven environments with cross-functional teams
Vacancy posted a month ago
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