Senior Scientist or Principal Scientist, Targeted Proteomics
Kymera Therapeutics
Kymera Therapeutics seeks a Senior or Principal Scientist in Targeted Proteomics to lead mass spectrometry-based assay development and execution supporting targeted protein degradation research programs. The role combines scientific strategy, experimental design, and cross-functional collaboration to advance clinical-stage therapeutics.
Responsibilities
- Partner with cross-functional teams to identify key scientific questions addressable by targeted proteomics
- Design, execute, and interpret targeted proteomics experiments across multiple biological matrices and species
- Develop and optimize LC-MS assays for pharmacodynamic profiling of degrader programs
- Lead assay transfer and qualification activities with external CRO partners
- Communicate scientific findings and strategic recommendations to internal and external stakeholders
Requirements
- PhD in Biochemistry, Biology, Chemistry, or Chemical Biology with 2+ years targeted proteomics experience in biotech
- BS/MS with 8+ years relevant industry experience in targeted proteomics accepted
- Expertise in translating biological questions into mass spectrometry experimental designs
- Proficiency with LC-MS platforms including nano-LC and Orbitrap instrumentation
- Experience developing, optimizing, and qualifying targeted proteomics assays
- Demonstrated ability to manage CRO partnerships and oversee external proteomics activities
$115k - $215k
...company pioneering the field of targeted protein degradation (TPD) to... ...can be addressed by targeted proteomics. Collaborate with... ...recommendations to project teams, senior leadership, and external collaborators... ..., solutions-oriented scientist with the ability to manage multiple...PrincipalSenior$179k - $236k
...with world-class computational biologists, machine learning scientists, experimental biologists, chemists, clinicians , and technologists... ...effects, validate hits and leads, and deconvolute targets and mechanism of actions. Work with experimental scientists...PrincipalSeniorFull timeShift work$138.6k - $257.4k
...highly motivated and experienced scientist to lead a small group of... ...integration of new spatial proteomics and imaging technologies across... ...teams to enable complex target discovery and validation across... ...Internal Job Title: Senior Principal Scientist / Associate Director...PrincipalSenior- Role: Lead scientist overseeing biochemical and biophysical assay strategies for early discovery of targeted protein degraders at C4 Therapeutics. Responsibilities: design and optimize... ...biology, computational chemistry, proteomics, and cell pharmacology; experience managing...Principal
$216k
...Physics Laboratory (APL) has an outstanding opportunity for a Senior Principal Scientist to join the Environmental and Information Systems... ...architectures. Particular attention is given to improving target detection classification tracking and localization in acoustically...PrincipalSeniorFull timeTemporary workWork at officeRemote workShift work$156.18k - $189.25k
...research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are... ..., experienced and talented Principal Scientist to join our Discovery Biosciences... ..., ELISA, MSD, and proteomics Experience with cancer model development...PrincipalHourly payFull timeSummer workLocal areaRemote workFlexible hours- Sanofi US Cambridge is seeking a Senior Principal Scientist in Type 2 Immunology to lead preclinical programs and translate insights into early clinical strategies across dermatology, gastroenterology, respiratory and rheumatology. You will operate at the interface of...PrincipalSenior
- ...sustainability - both environmental and social - is at the forefront of our decision making. About the Role Nanopath is seeking a Senior Scientist / Principal Scientist to join our Assay R&D team and lead verification and validation activities for Nanopath's diagnostic platform....PrincipalSeniorWork at office
- Bristol Myers Squibb seeks a Principal Scientist to join the Discovery Biosciences Genomics team in Cambridge, MA. Lead multi‑omics projects... ...cell RNA‑seq and spatial transcriptomics to advance oncology target identification, validation, and translational research. The...Principal
$119.7k - $222.3k
...overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist. Extensive and in-depth knowledge of pharmacokinetics including, drug...PrincipalSenior- Generate Biomedicines is seeking a Principal Scientist to lead Target Binding within our Protein Analytics & Biophysics (PAB) department. This role combines hands‑on technical work with strategy, cross‑functional program leadership, and mentoring of junior scientists....Principal
$146k - $236.5k
...a venture-backed stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here you will build the physics... ...AI platform. You will characterize how binders engage their targets and validate generated designs before they are committed to...PrincipalSenior$175k - $225k
...Scholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of... ...accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific... ...disease. Reporting to the Senior Director, Head of Biomarker Development...Principal$126k - $234k
...In Vivo Scientist This position is located in Cambridge, MA and does not have the ability to be located remotely. Please only apply... ...patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy....PrincipalRemote work$126k - $234k
...medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR‑T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate...PrincipalRemote work$143k - $214.5k
...transform agriculture. We areseekingan innovative and strategic Principal Scientist, Molecular Cloning Technologies to lead the vision,... ...Communicate scientific strategy, findings, and recommendations to senior leadership. PROFESSIONAL EXPERIENCE & QUALIFICATIONS Ph.D....PrincipalSenior- ...Biomedical Research is seeking a Translational Biomarker Strategy Lead to drive preclinical and translational biomarker strategies from target validation to early clinical planning. This role partners with Biology, In Vitro, In Vivo, Data Science, and Biomarker Development...Principal
$170k - $205k
...accomplished, technically driven Sr. Scientist II/ Principal Scientist to join our Chemical Biology team. This is a senior individual-contributor role for a proteomics and mass spectrometry expert who... ...drive chemoproteomic target discovery and validation efforts,...PrincipalSenior$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines... ...with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new...PrincipalShift work$148k - $208k
Cambridge, MA USA; London, UK; San Francisco, CA USA We're building a talent-dense, high-agency AI safety team at Lila that will engage all core teams within the organization (science, model training, lab integration, etc.), to identify and mitigate risks from scientific...PrincipalSeniorFull timeWork at officeLocal areaFlexible hours- Novartis AG in Cambridge, MA, onsite, is seeking a Principal Scientist I to drive frontier biology opportunities from concept to project initiation. You will lead hands-on lab work, interpret data, and guide projects with ambiguity, while working closely with junior researchers...Principal
- C4 Therapeutics, Inc. is seeking an innovative Principal Scientist, Biology (Immunology) to advance autoimmune and inflammatory disease programs... ...TORPEDO platform. This lab‑based role leads projects from target identification through IND‑enabling studies, applying deep...Principal
$160k - $224k
The Role: Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department... ...across multiple biotherapeutic programs,serving as a senior PAB representative on cross‑functional teams. Design,...PrincipalShift work$179.56k - $198.45k
...for an accommodation or an alternative application process. Principal Scientist, Biology (Immunology) Full Time Technical Watertown, MA, US... ...biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of...PrincipalFull time- Bristol Myers Squibb in Cambridge, MA is seeking a Senior Scientist, Targeted Delivery Biology to join the Non‑Viral Delivery team. You will drive mechanistic understanding and optimization of targeted nanoparticle delivery across cell types and tissues, blending cell...Senior
- Bristol Myers Squibb in Cambridge, MA seeks a Senior Scientist, Non-Viral Delivery Attribute Sciences to shape cellular- and mechanistic- understanding for next-generation targeted LNP therapies. You will develop cellular characterization strategies, advance high-throughput...Senior
- Bristol Myers Squibb Co is seeking a Senior Scientist to join the Non-Viral Delivery team in Cambridge, MA, advancing next-generation targeted nanomedicine. You will design bioconjugation strategies and engineering ligand architectures to enable selective delivery to challenging...Senior
- Bristol Myers Squibb in Cambridge, MA seeks a Senior Scientist in Bioconjugation & Targeted Nanomedicine to drive molecular design and analytical characterization of bioconjugates for targeted nanoparticle delivery. The role emphasizes cross-functional collaboration across...Senior
- Bristol Myers Squibb in Cambridge, MA is seeking a Senior Scientist, Targeted Delivery Biology to advance non-viral delivery platforms. You will drive mechanistic insight and optimize delivery to new cell types and tissues, bridging cell biology with delivery sciences...Senior
- Bristol Myers Squibb seeks a Senior Scientist, Non-Viral Delivery Attribute Sciences to shape the Attribute Sciences capability and define mechanisms driving targeted LNP performance. You will integrate datasets, expand characterization with new tech, and partner across...Senior
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Scientist or Principal Scientist, Targeted Proteomics. Be the first to apply!
- drug safety scientist Watertown, MA
- materials scientist Watertown, MA
- scientist biology Watertown, MA
- manufacturing scientist Watertown, MA
- cell culture scientist Watertown, MA
- water quality scientist Watertown, MA
- lab scientist Watertown, MA
- research scientist Watertown, MA
- deep learning scientist Watertown, MA
- machine learning research scientist Watertown, MA


