Principal Scientist: Frontier Target Discovery Leader
Novartis AG
Novartis AG in Cambridge, MA, onsite, is seeking a Principal Scientist I to drive frontier biology opportunities from concept to project initiation. You will lead hands-on lab work, interpret data, and guide projects with ambiguity, while working closely with junior researchers in a matrixed setting. The role requires a PhD with 2+ years of postdoc/industry experience, strong communication, and experience with AI-enabled workflows. #J-18808-Ljbffr Novartis AG
$108.5k - $201.5k
...highly curious, hands-on scientist to help build the next... ...generation of opportunities for Frontier Programs within the... ...Job Title: Principal Scientist IPosition Location... ...Understanding of early drug discovery and how experimental biology, target validation, and mechanistic...PrincipalTargetFull timeTraineeship- Novartis Institutes for BioMedical Research, Inc. in Cambridge, MA seeks a highly curious, hands-on Principal Scientist I to build the next generation of Frontier Programs in DAx. This lab-based role advances opportunities from hypotheses through project initiation with...Target
- Bristol Myers Squibb seeks a Principal Scientist to join the Discovery Biosciences Genomics team in Cambridge, MA. Lead multi‑omics projects using single... ...‑seq and spatial transcriptomics to advance oncology target identification, validation, and translational research....PrincipalTarget
$114.1k - $211.9k
...execution of preclinical and translational biomarker strategies from target validation through development candidate nomination and early... ...in translational research, biomarker strategy, biomarker discovery, or drug development within the pharmaceutical or biotechnology...PrincipalTargetFull timeLocal areaFlexible hours$156.18k - $189.25k
...development engine, responsible for the discovery and development of novel oncology... ...sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory... ...motivated, experienced and talented Principal Scientist to join our Discovery...PrincipalTargetHourly payFull timeSummer workLocal areaRemote workFlexible hours$160k - $224k
...Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics... ...across multiple biotherapeutic discovery and development programs. The role... ...scientific outcomes.• Collaborative leader who develops people and builds...PrincipalTargetShift work$175k - $225k
...siteScholar Rock is delivering muscle-targeted breakthroughs to transform... ...unmet need.As a global leader in myostatin biology, a... ...accomplished and highly collaborative Principal Scientist, Biomarker Development, to... ...individual will support the discovery, development, and...PrincipalTargetFull time- ...Biomedical Research is seeking a Translational Biomarker Strategy Lead to drive preclinical and translational biomarker strategies from target validation to early clinical planning. This role partners with Biology, In Vitro, In Vivo, Data Science, and Biomarker Development...PrincipalTarget
- ...Bristol Myers Squibb seeks a Principal Scientist for its Discovery BioSciences Genomics team in Cambridge, MA. The role focuses on wet lab research using... ...transcriptomics—to advance oncology drug discovery and target identification with minimal supervision....PrincipalTarget
$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical... ...biologically important targets long considered... ...Experience in oncology drug discovery is strongly preferred. Familiarity... ...fiercely independent as a leader in defying the limitations...PrincipalTargetShift work$142.5k - $256.5k
...RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics... ...including biological and therapeutic-area research, target and antigen strategy, immunization and B cell discovery...PrincipalTargetPermanent employmentFull timeWork from home$187.63k - $207.38k
Principal Scientist in Immunology C4 Therapeutics is seeking a highly motivated and innovative Principal... ...Scientist in Immunology to lead discovery and translational research for... ...and inflammatory diseases within our targeted protein degradation (TPD) platform. In...PrincipalTarget$230.09k - $254.31k
...dedicated to delivering on the promise of targeted protein degradation science to create a... ..., working in lockstep with internal Discovery, Supply Chain, Quality, and external CDMO... ...Direct and evaluate the work of external scientists and suppliers, including vendor identification...PrincipalTargetContract work$179.56k - $198.45k
...or an alternative application process. Principal Scientist, Biology (Immunology) Full Time... ...dedicated to delivering on the promise of targeted protein degradation science to create... ...mechanistic readouts. Lead immunology discovery programs from target identification through...PrincipalTargetFull time$215k - $245k
Principal Scientist, Translational Data Science Cambridge Parabilis Medicines... ...biologically important targets long considered undruggable.... ...role is a senior scientific leader within Translational Medicine... ...biomarkers, data, and insights from discovery into development. The ideal...PrincipalTargetShift work- Principal Scientist, AI-Native Discovery (Large Molecules) Johnson & Johnson Innovative Medicine is recruiting for a Principal Scientist, AI-Native Discovery... .... Preferred Qualifications Experience in therapeutic target analysis, structural biology, antibody-antigen...PrincipalTargetContract workRemote work
$117k - $201.25k
...recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job... ...are searching for the best talent for a Principal Scientist, Animal Genetic Engineering - Antibody... ...against historically challenging target classes, including multi-pass membrane...PrincipalTargetContract workLocal areaImmediate start$146k - $236k
...AI and Engineering teams, feeding field discoveries back as product requirements. The role owns... ...conditions for milestone decisions (target engagement, therapeutic window, modality... ...decision types Preferred Experience applying frontier AI and LLM tools to drug development...PrincipalTarget- Generate Biomedicines is seeking a Principal Scientist to lead Target Binding within our Protein Analytics & Biophysics (PAB) department. This role combines hands‑on technical work with strategy, cross‑functional program leadership, and mentoring of junior scientists....PrincipalTarget
- C4 Therapeutics, Inc. is seeking an innovative Principal Scientist, Biology (Immunology) to advance autoimmune and inflammatory disease programs... ...TORPEDO platform. This lab‑based role leads projects from target identification through IND‑enabling studies, applying deep...PrincipalTarget
- ...Generate Biomedicines seeks a Principal Scientist to lead target binding efforts within the Protein Analytics & Biophysics department. This role combines... ...of junior scientists across multiple biotherapeutic discovery programs. Responsibilities Lead target binding...PrincipalTarget
- ...Proteomics Scientist Location: This role is based in-person at... ...Our platform brings together frontier AI models, a scalable data generation... ..., previously intractable targets, and in particular unlocks... ...promising frontiers in modern drug discovery with the potential to treat...Target
$170k - $205k
...Therapeutics is seeking an accomplished, technically driven Sr. Scientist II/ Principal Scientist to join our Chemical Biology team. This is a... ...expert who can independently drive chemoproteomic target discovery and validation efforts, as well as hit identification and...PrincipalTarget$212k - $333.19k
...the best of my knowledge.Job DescriptionSenior Director, AIRx Discovery Biology Lead Takeda Research is constructing the Discovery Automation... ...whether a program deserves to advance, guiding the team from target hypothesis to clinical hypothesis with the intellectual...TargetMinimum wageLocal areaRemote work$138.6k - $257.4k
...highly motivated and experienced scientist to lead a small group of... ...teams to enable complex target discovery and validation across disease... ...DescriptionInternal Job Title: Senior Principal Scientist/Associate... ...to project teams, research leaders, and senior stakeholders.Essential...PrincipalTargetFull time- ...accomplished and highly collaborative scientist to lead the Cellular Biology... ...serve as both a scientific leader and a hands‑on... ...to identify novel druggable targets, therapeutic approaches, and... ...mechanistic hypotheses and guide drug‑discovery strategy. Develop and optimize...PrincipalTarget
- Sanofi Cambridge, MA is seeking a Scientist I for a 6-month contract to support early pipeline programs. The role focuses on translating... ...analyses, and collaborate with cross-functional teams to advance targets toward IND/CTA readiness. Strong documentation and...TargetContract work
- Biohaven in Cambridge, MA is seeking a contract-to-hire Scientist/Sr. Scientist to build and elevate our Mass... ...-on, on-site role shaping bioanalytical strategy for discovery programs, with a focus on targeted degradation and next-generation biologics. The ideal...Contract work
$146k - $236.5k
...stealth AI x bio company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations. Here... ...characterize how binders engage their targets and validate generated designs before... ..., at least part of it in a drug discovery setting (Sr. Scientist); 6+ years with...PrincipalTarget$216k - $297k
...for a team of talented machine learning scientists innovating on model architectures that... ...relevant to mechanism-of-action reasoning, target discovery, perturbation biology, pathway... ...scientists, executives, and venture creation leaders.Comfort operating in an entrepreneurial...PrincipalTarget
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