Principal Scientist: Target Binding & Biophysics
Generate Biomedicines
Generate Biomedicines is seeking a Principal Scientist to lead Target Binding within our Protein Analytics & Biophysics (PAB) department. This role combines hands‑on technical work with strategy, cross‑functional program leadership, and mentoring of junior scientists. The successful candidate will be an industry expert in quantitative biophysical assay development for challenging systems, including membrane proteins and multispecific molecules, and will drive technology platform advancement with #J-18808-Ljbffr Generate Biomedicines
$160k - $224k
The Role: Generate is seeking an accomplished Principal Scientist to lead Target Binding efforts within our Protein Analytics & Biophysics (PAB) department.This individual will provide scientific and strategic leadership for protein-protein interaction, target-binding,...PrincipalTargetShift work- ...Generate Biomedicines seeks a Principal Scientist to lead target binding efforts within the Protein Analytics & Biophysics department. This role combines technical expertise in biophysical assay development, technology innovation, cross-functional program leadership,...PrincipalTarget
$146k - $236.5k
...company, is seeking a Sr. Scientist / Principal Scientist, Molecular Simulations... ...how binders engage their targets and validate generated... ...Target Assessment: Characterize binding sites, including cryptic... ...in computational chemistry, biophysics, chemical physics, structural...PrincipalTarget$175k - $225k
...Development /Full-Time /On-siteScholar Rock is delivering muscle-targeted breakthroughs to transform the treatment of spinal muscular... ...Rock is seeking an accomplished and highly collaborative Principal Scientist, Biomarker Development, to provide scientific leadership for...PrincipalTargetFull time$108.5k - $201.5k
...are seeking a highly curious, hands-on scientist to help build the next generation of opportunities... ....Job DescriptionInternal Job Title: Principal Scientist IPosition Location: Cambridge,... ...discovery and how experimental biology, target validation, and mechanistic evidence...PrincipalTargetFull timeTraineeship$179k - $200k
...functions including computational chemistry, biophysics, structural biology, and biology teams... ...to ensure timely delivery of complex target molecules for biological testing. Ensure... ...with a talented and passionate team of scientists Be a part of a cutting-edge company that...PrincipalTarget- Bristol Myers Squibb seeks a Principal Scientist to join the Discovery Biosciences Genomics team in Cambridge, MA. Lead multi‑omics projects... ...cell RNA‑seq and spatial transcriptomics to advance oncology target identification, validation, and translational research. The...PrincipalTarget
$108k - $128k
...Principal Associate Scientist Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines... ...with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new...PrincipalTargetShift work$114.1k - $211.9k
...on DAx project teams.This role will lead the development and execution of preclinical and translational biomarker strategies from target validation through development candidate nomination and early clinical planning. The Biomarker Strategy Lead will partner closely with...PrincipalTargetFull timeLocal areaFlexible hours- ...Biomedical Research is seeking a Translational Biomarker Strategy Lead to drive preclinical and translational biomarker strategies from target validation to early clinical planning. This role partners with Biology, In Vitro, In Vivo, Data Science, and Biomarker Development...PrincipalTarget
- Novartis AG in Cambridge, MA, onsite, is seeking a Principal Scientist I to drive frontier biology opportunities from concept to project initiation. You will lead hands-on lab work, interpret data, and guide projects with ambiguity, while working closely with junior researchers...PrincipalTarget
- C4 Therapeutics, Inc. is seeking an innovative Principal Scientist, Biology (Immunology) to advance autoimmune and inflammatory disease programs... ...TORPEDO platform. This lab‑based role leads projects from target identification through IND‑enabling studies, applying deep...PrincipalTarget
$187.63k - $207.38k
Principal Scientist in Immunology C4 Therapeutics is seeking a highly motivated and innovative Principal Scientist in Immunology to lead discovery... ...for autoimmune and inflammatory diseases within our targeted protein degradation (TPD) platform. In this role, you will drive...PrincipalTarget$230.09k - $254.31k
...biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of... ...processes. Direct and evaluate the work of external scientists and suppliers, including vendor identification, RFP technical...PrincipalTargetContract work$179.56k - $198.45k
...for an accommodation or an alternative application process. Principal Scientist, Biology (Immunology) Full Time Technical Watertown, MA, US... ...biopharmaceutical company dedicated to delivering on the promise of targeted protein degradation science to create a new generation of...PrincipalTargetFull time$215k - $245k
Principal Scientist, Translational Data Science Cambridge Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating... ...with serious diseases by unlocking biologically important targets long considered undruggable. The company has pioneered a new...PrincipalTargetShift work$156.18k - $189.25k
...state-of-the-art research sites in Cambridge and Seattle, scientists focus on novel targets and pathways for tumors that are refractory to current... ...are seeking a highly motivated, experienced and talented Principal Scientist to join our Discovery Biosciences Genomics...PrincipalTargetHourly payFull timeSummer workLocal areaRemote workFlexible hours- Role: Lead scientist overseeing biochemical and biophysical assay strategies for early discovery of targeted protein degraders at C4 Therapeutics. Responsibilities: design and optimize assays to characterize protein interactions, lead complex operational workstreams, interpret...Principal
$142.5k - $256.5k
...accomplished and highly motivated Principal Scientist to join the Antibody Discovery... ...and therapeutic-area research, target and antigen strategy,... ...candidates using biochemical, biophysical, and functional assays to assess binding, affinity, specificity, epitope...PrincipalTargetPermanent employmentFull timeWork from home$108.5k - $201.5k
...Description SummaryInternal Position Title: Principal Scientist I/IILocation: Cambridge, MA, #LI-Onsite... ..., genetic, and genomic) to support target engagement, pharmacodynamics, and... ...optimizing, and clinically implementing ligand binding assays (e.g. ELISA, MSD, immunoassays)....PrincipalTargetFull timeRelocation package$172k - $241k
...seeking a creative and rigorous scientist to develop computational... ...successful approaches reusable across targets and programs.Here's how you... ...generative, predictive, and biophysical approaches. Create scores and... ...of properties such as binding specificity, conditional activity...TargetWork at officeShift work$125k - $155k
...siteScholar Rock is delivering muscle-targeted breakthroughs to transform... ...and collaborative Senior Scientist to join the Antibody... ...leads through biochemical and biophysical characterization. Hands-on experience... ...methods.Characterize binding, specificity, affinity,...Full time$117k - $201.25k
...are searching for the best talent for a Principal Scientist, Vector Biology to be in Cambridge, MA.... ...receptor localization and ligand/virus binding, dissecting entry pathways, and... ...vector systems to study the transduction of target cells and to develop novel gene delivery...PrincipalTargetLocal areaImmediate start$138.6k - $257.4k
...seeking a highly motivated and experienced scientist to lead a small group of biologists with... ...across matrix teams to enable complex target discovery and validation across disease... ...Job DescriptionInternal Job Title: Senior Principal Scientist/Associate DirectorPosition...PrincipalTargetFull time- ...needs. We are seeking an accomplished and highly collaborative scientist to lead the Cellular Biology function. The ideal candidate will... ...hematology and bone marrow biology to identify novel druggable targets, therapeutic approaches, and opportunities addressing unmet needs...PrincipalTarget
$146k - $236k
...the decision’s timeline Deliver translational predictions with stated confidence and boundary conditions for milestone decisions (target engagement, therapeutic window, modality feasibility, competitive differentiation) Quantify probability of pharmacological success...PrincipalTarget- ...Bristol Myers Squibb seeks a Principal Scientist for its Discovery BioSciences Genomics team in Cambridge, MA. The role focuses on wet lab... ...spatial transcriptomics—to advance oncology drug discovery and target identification with minimal supervision. Responsibilities...PrincipalTarget
$216k - $297k
...will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-... ...reason over modalities relevant to mechanism-of-action reasoning, target discovery, perturbation biology, pathway reasoning, protein function...PrincipalTarget$121.28k - $202.13k
...of disease together.Find out more:Our approach to R&DPrincipal Scientist (m/f/d) Genomic Technologies, Human Genetics and GenomicsThis position... ..., disease-relevant mechanisms and cell types, potential drug targets, candidate biomarkers, patient subgroups and disease subtypes,...PrincipalTargetFull timeWork at officeLocal area- Principal Scientist, Translational Computational Biology within BMS's Oncology Translational IPS team, focusing on embedding computational expertise... ...patient stratification strategies interpret data to inform target validation, IND-enabling studies, and early clinical...PrincipalTarget
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