Senior Manager, Corporate Development

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.

We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.

The Senior Manager, Corporate Development will help shape Denali's corporate and portfolio strategy, source, evaluate and execute external partnerships, support key alliances, and support investor relations. Reporting to the Executive Director, Corporate Development, this individual will work closely with senior leadership and cross-functional partners as a trusted, versatile business partner who can move fluidly across science, strategy, finance, partnering and other business questions and decisions.


This role is both strategic and operational, and a successful applicant will bring structured problem solving, creativity, and business rigor to enable high-impact initiatives and decisions across Denali.

Key Accountabilities/Core Job Responsibilities:

• Develop and present corporate and portfolio strategy recommendations in close collaboration with R&D, operations, finance, commercial, and executive leadership
• Support program-level decision-making through strategic framing and rigorous analysis
• Assess inbound and outbound partnering opportunities and lead diligence efforts
• Develop and recommend potential deal structures, including key business and financial terms
• Drive negotiations of term sheets and definitive agreements in collaboration with senior leadership, legal, finance, and other internal stakeholders
• Coordinate with leadership and project teams to manage existing alliances and drive productive partner relationships
• Contribute to development of investor-facing materials and messaging, including around key corporate milestones and conferences

Qualifications/Skills:

• Passionate about science, medicine, and business and intellectually curious
• Advanced degree, such as an MBA, PhD, MD, or JD, strongly preferred
• Typically 4+ years of experience in investment banking, venture capital, management consulting, corporate development, business development, or biopharma strategy roles
• Demonstrated ability to operate independently, manage ambiguity, and drive multiple high-priority initiatives in an intense, fast-paced environment
• Highly collaborative, with experience building trust across cross-functional teams
• Strong business instincts and ability to think strategically and analytically
• Fluency in financial modeling, business analytics, and basic valuation methodologies
• Facility with the language of science
• Strong executive presence and outstanding written and verbal communication skills

Salary Range: $151,000.00 to $196,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at

This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.

Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.