Vice President, U.S. Market Access
$278k - $361kJobleads-US
- # Vice President, U.S. Market AccessApplylocations: South San Franciscotime type: Full timeposted on: Posted 3 Days Agojob requisition id: R-1573Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.The Vice President of Market Access will lead the strategy, development, and execution of U.S. market access capabilities to support Denali’s mission to deliver transformative therapies for neurodegenerative and lysosomal storage diseases. This role will be critical in preparing for and executing successful launches (e.g., AVLAYAH/tividenofusp alfa) and ensuring sustained access across the lifecycle, including accelerated approval (AA) conversion and global expansion. This leader will lead a best-in-class market access organization that integrates payer strategy, pricing, reimbursement, patient support, and evidence generation. The VP will partner closely across Commercial, Patient Advocacy, Medical Affairs, Clinical Development, and Regulatory to ensure access considerations are embedded early and effectively across development programs and future pipeline assets. In addition, this individual may serve as Project Team Lead for one of Denali's late-stage pipeline programs — acting as the strategic anchor for a cross-functional team spanning clinical, regulatory, CMC, and commercial functions. Accountable for integrated planning and execution, they will ensure the program advances with speed, scientific rigor, and an unwavering commitment to patient impact.**Key Accountabilities/Core Job Responsibilities**:*US Market Access Leadership** Lead U.S. market access strategy for Denali’s portfolio, including launch and post-launch optimization for AVLAYAH and future pipeline assets.* Develop integrated strategies across payer engagement, coverage, reimbursement, and patient support tailored to rare disease and specialty infusion/orphan markets.* Shape access strategy to support accelerated approval pathways and subsequent label expansion (e.g., sBLA, lifecycle management).* Partner with Commercial leadership to define go-to-market strategy, including patient segmentation, site-of-care strategy, and provider access pathways.* Provides executive leadership to the US Market Access Leadership Team, with oversight spanning Payer Field Team, Patient Access and Experience, Pricing, Contracting, Channel Operations and Strategy, and Government Price Reporting.*Payer, Pricing, and Policy Strategy** Lead engagement strategy across commercial and government payers, addressing complex coverage dynamics in rare and ultra-rare diseases.* Develop and execute pricing and contracting strategies, including gross-to-net optimization and value-based considerations where appropriate.* Anticipate and navigate evolving payer policies related to gene/enzyme therapies, biomarkers, and surrogate endpoints.* Provide strategic guidance to executive leadership on reimbursement risks, policy changes, and access barriers.*Evidence Generation & Value Demonstration** Define payer value proposition grounded in clinical, biomarker, and real-world evidence (e.g., HS/CSF HS endpoints).* Lead development of value dossiers, HEOR models, and access-focused evidence strategies to support coverage and AA-to-full approval conversion.* Partner with Medical Affairs and Clinical teams to ensure access-relevant endpoints and RWE strategies are incorporated into studies (e.g., COMPASS, E8).* Support publication and communication strategies to reinforce value with payers and key stakeholders.*Patient Access & Support Programs** Design and oversee patient support infrastructure, including HUB services, prior authorization support, and affordability programs.* Ensure seamless patient onboarding and therapy initiation, particularly for complex infusion-based therapies.* Oversee compassionate use and early access programs, ensuring alignment with ethical, regulatory, and patient-centric principles.* Continuously optimize patient experience and reduce barriers to treatment.*Trade, Distribution & Site-of-Care Strategy** Define and manage specialty pharmacy and distribution strategy, including site-of-care optimization (e.g., CoEs, infusion centers).* Partner with Supply Chain and Commercial teams to ensure reliable and efficient product access.* Align channel strategy with patient journey and payer requirements.*Operations, Analytics & Performance** Establish and track key access metrics, including time-to-therapy, patient onboarding, and payer approval rates.* Drive data-driven decision-making to optimize access performance and patient outcomes.* Lead continuous improvement initiatives to enhance operational efficiency and scalability.*Pipeline & Global Alignment** Partner with Global Insights and Operations to assess access strategy for pipeline and external assets.* Ensure scalability of access infrastructure to support global expansion and future indications.* Align U.S. access strategy with global evidence and regulatory strategies where appropriate.*Leadership & Cross-Functional Influence** Lead a high-performing, agile market access team.* Serve as a key member of the CMPA Leadership Team and strategic advisor to executive leadership.* Collaborate closely with CMPA, Medical Affairs, Clinical Development, Regulatory, Legal, Compliance, Finance, and Commercial teams.* Drive alignment across functions to deliver a cohesive, patient-centered access strategy.* Lead direct report(s) through annual goal setting, growth planning, adherence to company policies, maintain training compliance and provide ongoing feedback on growth, development and areas of improvement.**Qualifications/Skills****:*** Typically requires a Bachelor’s degree and 20+ years of experience in biotech/pharma, including senior leadership roles in market access and 15+ years of people leadership experience; an advanced degree (MBA, MPH, PharmD, PhD) is preferred.* Deep expertise in U.S. payer systems, reimbursement, and specialty/orphan drug access dynamics.* Strong understanding of biomarker-driven development, surrogate endpoints, and their implications for payer acceptance.* Experience with HEOR, RWE, and value-based access strategies in complex disease areas.* Proven ability to shape payer perception and navigate ambiguity in emerging therapeutic areas.* Strong strategic thinking combined with hands-on execution.* Excellent leadership, communication, and stakeholder management skills.* Ability to operate effectively in a fast-paced, evolving environment.* High integrity and commitment to compliance and patient-centric decision-making.* Proven experience launching therapies in rare disease, neurology, or specialty markets.* Strong experience with accelerated approval pathways, lifecycle management, and evidence-based access strategies.* Experience in pre-commercial or emerging biotech environments preferred.Salary Range: $278,000.00 to $361,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at
- J-18808-Ljbffr Jobleads-US
Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Vice President, U.S. Market Access in South San Francisco, CA vacancy
- ...Key Accountabilities / Core Job Responsibilities Lead U.S. market access strategy for Denali’s portfolio, including launch and post-launch optimization for AVLAYAH and future pipeline assets. Develop integrated payer engagement, coverage, reimbursement, and patient...Market access
- ...Scorpion Therapeutics is seeking an experienced market access leader to spearhead strategies for Denali’s portfolio. The ideal candidate will have over 20 years of biotech or pharma experience and will excel in developing payer engagement and patient support programs....Market access
- ...U.S. Private Bank - Private Banker - Vice President or Executive Director Job Information Job Identification 210597944 Job Category Client Advisory... ...alongside a team of talented colleagues from other markets, businesses and functions to provide you with the opportunity...SuggestedFull timeTemporary workWork experience placementLocal area
JPMorgan Chase & Co.
San Francisco, CA2 days ago $300k - $385k
...The Role Peregrine is seeking a Vice President of Government Affairs to build and lead... ...State strategies, unlocks funding and market access, and protects the company as it scales... ...with top business priorities, including U.S. government customers, program execution...Market accessContract workWork at officeLocal areaPeregrine Technologies
San Francisco, CA19 hours ago- Position Overview Nurix Therapeutics is seeking a Vice President, Medical Affairs, Hematology‑Oncology to build, expand, and lead a best... ...‑functional partner to Clinical Development, Commercial, Market Access, Regulatory, Legal, and Compliance as Nurix plans and executes...Market access
- ...Denali Therapeutics Inc. is looking for a Vice President, U.S. Market Access, to lead market access strategies for their innovative portfolio. You will shape access for transformative therapies in neurodegenerative diseases, ensuring successful launches and sustained...Market access
- ...Denali Therapeutics Inc. is looking for a Vice President of Market Access to lead its U.S. market access strategy for neurodegenerative therapies. This role is pivotal for preparing successful launches and ensuring access across the product lifecycle, necessitating a deep...Market access
- ...provide a first‑class experience to clients within J.P. Morgan’s U.S. Private Bank. If you have an entrepreneurial mindset and are looking... ...be working alongside a team of talented colleagues from other markets, businesses and functions to provide you with the opportunity to...
SupportFinity
San Francisco, CA4 days ago $360k - $425k
...scale to more patients. About the role: The Vice President, Clinical Development will work across... ...in clinical trial as well as post-marketing setting (cell therapy experience highly... ...Candidates must be authorized to work in the U.S We offer a chance to work with talented...InternshipWork at officeLocal areaRemote workAllogene Therapeutics
South San Francisco, CA3 days ago- ...provide a first-class experience to clients within J.P. Morgan’s U.S. Private Bank. If you have an entrepreneurial mindset and are looking... ...be working alongside a team of talented colleagues from other markets, businesses and functions to provide you with the opportunity to...Temporary workWork experience placementLocal area
$198k - $245k
...role will ensure accurate revenue recognition in accordance with U.S. GAAP while building scalable processes, systems, and... ...other variable consideration components. Partner with Commercial, Market Access, Trade, and Government Pricing to align GTN assumptions with contracting...Market accessTemporary work$342.8k
Job Description The Associate Vice President (AVP) is primarily responsible for planning and directing... ...research activities involving new or marketed drugs for oncology indications. The AVP... ...about personal rights under the U.S. Equal Opportunity Employment laws, visit...Worldwide$182.07k - $235.62k
...therapies that help improve lives and to ensure access to these therapies across the globe. We... .... Reporting to the Executive Director, U.S. Prevention Public Affairs, the Associate... ..., Clinical Development, Commercial, Market Access, Government Affairs, Legal, Regulatory...Market accessFull timeFor contractorsLocal areaWorldwide$243k - $299k
...oversee compliance initiatives related to Fair Market Value (FMV) payments, Transfer of Value... ..., Finance, IT, Contracts, Market Access, and other stakeholders to ensure adherence... ...life sciences industry. Strong knowledge of U.S. and global healthcare compliance regulations...Market accessWork experience placementWork at officeLocal areaFlexible hours3 days per weekDenali Therapeutics
South San Francisco, CA4 days ago$263.88k - $307.86k
...with benefit-risk profile, labeling, post marketing commitments, and lifecycle plans. Drives... ...regulatory guidance to Commercial, Market Access, and Patient Services to ensure compliant... ...#LI-HYBRID**Pay Range:**In the U.S., the hiring pay range for fully qualified...Market accessFor contractors$120k - $145k
...one commercial product with guidance. Partner with Commercial, Market Access, Supply Chain, FP&A, and other internal teams to understand... ...Experience with inventory accounting is a plus Strong understanding of U.S. GAAP, particularly revenue recognition (ASC 606) Analytical...Market accessContract work$270k - $315k
...measurement, patient services analytics, access analytics, and AI-enabled analytical capabilities... ...strategies, patient support programs, market access initiatives, and organizational... ...preferred. #LI-HYBRID**Pay Range:**In the U.S., the hiring pay range for fully qualified...Market access$270k - $320k
...Operations to lead the vision, design, and implementation of U.S. trade and distribution models across its dermatology... ...and providers through agile, efficient, and scalable access pathways. Reporting to the SVP, Market Access, this role will operate as a core member of a...Market accessLocal area$269k - $332k
...responsible for developing and executing IDEAYA’s U.S. trade, channel, and distribution... ...). The role will ensure optimal product access and availability across the distribution and... ...with channel partners. Collaborate with Market Access to evaluate and implement contracting...Market accessTemporary workWork at office- ...are seeking a dynamic and experienced Vice President of Marketing with extensive experience launching new... ...insights and analytics, market access, and sales in order to produce high quality... ...the biotech/pharmaceutical industry U.S. Hematology/Oncology launch experience...Market access
- ...models. The ideal candidate has a doctoral degree and 10-15 years of relevant experience in the biotech sector, particularly with US market access strategies. This is an in-office position with a competitive rewards package, including salary and benefits. #J-18808-Ljbffr...Market accessWork at office
- ...Executive Marketing Director - Gastroenterology Why Genentech We’re passionate about delivering... ...for launch. The GI EMD reports to the Vice President of Genentech Immunology, sits on the... ...Ecosystems, Public Affairs & Access, and all Functional and Development Partners...Market accessTemporary workWork experience placementLive inLocal areaRelocation package
F. Hoffmann-La Roche AG
South San Francisco, CA3 days ago - ...for leading a large organization that is pivotal in meeting market access financial commitments and ensuring compliance with regulatory... ...business impact and innovation. Hiring Manager Title Vice President of Channel and Contract Management Travel Percent Less...Market accessContract work
- ...the launch of darovasertib. This critical role involves collaboration with various teams to generate robust evidence and support market access for patients with metastatic uveal melanoma. The ideal candidate will hold a doctoral level degree and possess at least 10-15...Market access
$235.1k
...contract payments and ensures compliance while optimizing revenue strategies. The ideal candidate will have substantial experience in market access and contract negotiations, with a strong leadership background. This position offers a salary range of $235,100 to $436,500...Market accessContract work$161.8k - $300.6k
...This role will serve as a lead strategic partner, engaging with National and Regional Therapeutic Area Experts to drive market influence and patient access. The ideal candidate possesses deep industry knowledge, strong interpersonal skills, and a Bachelor’s degree in a...Market access- ...Regenerative Medicine HEOR-Strategy team in South San Francisco. The role involves leading strategic research for pipeline and on-market products, with responsibilities that require expertise in patient-centered outcomes research and HEOR strategy. You will collaborate...Market access
- ...professionals. This role is pivotal in managing annual contract payments of approximately $10B, developing strategies for effective market access and compliance. The ideal candidate will possess strong leadership skills, and extensive experience in contract negotiations and...Market accessContract work
$300k - $385k
...Global Vice President, Revenue Operations CoreWeave | Posted Mar 14 | Full-time... ...growth across our global go-to-market organization. This is a... ...Compliance This position requires access to export controlled information. To conform to U.S. Government export regulations...Permanent employmentFull timeContract workTemporary workCasual workWork at officeRemote workFlexible hoursSupportFinity
San Francisco, CA4 days ago$110k - $195k
A satellite communications company in San Francisco is seeking a Market Access Manager to drive market access efforts outside the U.S. This role involves obtaining licenses, engaging with regulatory authorities, and optimizing regulatory frameworks for satellite operations...Market access
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Vice President, U.S. Market Access. Be the first to apply!
Related searches
- vp of accounting South San Francisco, CA
- senior vice president of operations South San Francisco, CA
- vice president project management South San Francisco, CA
- vp customer service South San Francisco, CA
- vp support South San Francisco, CA
- vice president of accounting South San Francisco, CA
- vice president program management South San Francisco, CA
- vp procurement South San Francisco, CA
- vice president for university advancement South San Francisco, CA
- vice president manufacturing South San Francisco, CA